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Spero Therapeutics, Inc. SPRO

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1.07 USD +0.03 (+2.88%)

At closeNov 4, 2026, 5:48 PM EST

1.06 -0.01 -0.93%

After hours · Nov 4, 5:48 PM ET

1.05 Day range 1.09
1.03 52-week range 3.08
YTD
-54.08%
1 year
-54.47%

Financial health

Altman Z-Score

-5.89 Distress zone

Bankruptcy-risk model: below 1.81 distress, above 2.99 safe.

Piotroski F-Score

6 / 9 Average

Nine pass/fail tests of profitability, leverage and efficiency.

FMP rating

A-4 / 5 overall

  • DCF 1
  • Return on Equity 4
  • Return on Assets 5
  • Debt / Equity 4
  • P/E 3
  • P/B 3

Valuation

P/E 15.5×
FY 2016: -3.0×FY 2017: -0.7×FY 2018: -2.4×FY 2019: -2.9×FY 2020: -5.5×FY 2021: -5.5×FY 2022: -1.4×FY 2023: 3.4×FY 2024: -0.8×FY 2025: 15.5×
FY 2016 5y median -0.8× FY 2025
P/S 2.2×
FY 2016: 227×FY 2017: 15.4×FY 2018: 24.8×FY 2019: 9.6×FY 2020: 46.5×FY 2021: 161×FY 2022: 1.3×FY 2023: 0.7×FY 2024: 1.2×FY 2025: 2.2×
FY 2016 5y median 1.3× FY 2025
P/B 2.2×
FY 2016: 7.5×FY 2017: 0.4×FY 2018: 0.8×FY 2019: 2.3×FY 2020: 3.3×FY 2021: 5.6×FY 2022: 0.9×FY 2023: 0.7×FY 2024: 1.2×FY 2025: 2.2×
FY 2016 5y median 1.2× FY 2025
P/FCF -10.3×
FY 2016: -2.5×FY 2017: -0.8×FY 2018: -2.3×FY 2019: -3.5×FY 2020: -5.0×FY 2021: -7.7×FY 2022: -8.4×FY 2023: -2.3×FY 2024: -2.4×FY 2025: -10.3×
FY 2016 5y median -7.7× FY 2025
EV/EBITDA 10.5×
FY 2016: -2.0×FY 2017: 1.4×FY 2018: -1.5×FY 2019: -2.4×FY 2020: -4.6×FY 2021: -4.5×FY 2022: 0.9×FY 2023: 0.2×FY 2024: -0.1×FY 2025: 10.5×
FY 2016 5y median 0.2× FY 2025
EV/Sales 1.6×
FY 2016: 196×FY 2017: -28.7×FY 2018: 16.2×FY 2019: 8.3×FY 2020: 38.2×FY 2021: 127×FY 2022: -0.8×FY 2023: 0.1×FY 2024: 0.1×FY 2025: 1.6×
FY 2016 5y median 0.1× FY 2025
FCF Yield -9.7%
FY 2016: -39.2%FY 2017: -128.8%FY 2018: -42.7%FY 2019: -28.8%FY 2020: -19.8%FY 2021: -13.0%FY 2022: -11.9%FY 2023: -42.6%FY 2024: -42.1%FY 2025: -9.7%
FY 2016 5y median -13.0% FY 2025

Profitability

Gross Margin 100.0%
FY 2016: -7760.6%FY 2017: -1560.9%FY 2018: -754.4%FY 2019: -262.5%FY 2020: -618.1%FY 2021: 100.0%FY 2022: 100.0%FY 2023: 50.4%FY 2024: -101.7%FY 2025: 100.0%
FY 2016 5y median 100.0% FY 2025
Operating Margin -0.0%
FY 2016: -9916.7%FY 2017: -2108.6%FY 2018: -1079.3%FY 2019: -348.4%FY 2020: -847.9%FY 2021: -2865.5%FY 2022: -86.9%FY 2023: 20.7%FY 2024: -152.9%FY 2025: -0.0%
FY 2016 5y median -86.9% FY 2025
Net Margin 14.4%
FY 2016: -7609.3%FY 2017: -2329.3%FY 2018: -1050.5%FY 2019: -335.7%FY 2020: -839.0%FY 2021: -2923.6%FY 2022: -95.5%FY 2023: 22.0%FY 2024: -142.9%FY 2025: 14.4%
FY 2016 5y median -95.5% FY 2025
ROE 14.5%
FY 2016: -250.7%FY 2017: -54.3%FY 2018: -36.0%FY 2019: -81.7%FY 2020: -59.3%FY 2021: -101.7%FY 2022: -61.1%FY 2023: 21.3%FY 2024: -148.7%FY 2025: 14.5%
FY 2016 5y median -61.1% FY 2025
ROIC -0.0%
FY 2016: -484.7%FY 2017: -48.5%FY 2018: -36.7%FY 2019: -78.7%FY 2020: -56.5%FY 2021: -57.2%FY 2022: -40.2%FY 2023: 13.1%FY 2024: -116.0%FY 2025: -0.0%
FY 2016 5y median -40.2% FY 2025
ROA 12.4%
FY 2016: -185.1%FY 2017: -49.3%FY 2018: -32.3%FY 2019: -57.4%FY 2020: -51.0%FY 2021: -52.5%FY 2022: -37.2%FY 2023: 12.5%FY 2024: -62.0%FY 2025: 12.4%
FY 2016 5y median -37.2% FY 2025

Growth (YoY)

Revenue 24.3%
FY 2016: 0.0%FY 2017: 490.7%FY 2018: 100.4%FY 2019: 357.6%FY 2020: -48.6%FY 2021: -67.1%FY 2022: 1482.4%FY 2023: 113.6%FY 2024: -53.8%FY 2025: 24.3%
FY 2016 FY 2025
Operating Income 100.0%
FY 2016: -149.3%FY 2017: -25.6%FY 2018: -2.6%FY 2019: -47.7%FY 2020: -25.1%FY 2021: -11.2%FY 2022: 52.0%FY 2023: 150.9%FY 2024: -441.5%FY 2025: 100.0%
FY 2016 FY 2025
EPS (diluted) 111.8%
FY 2016: -150.6%FY 2017: -361.7%FY 2018: 85.4%FY 2019: -27.3%FY 2020: -6.3%FY 2021: 17.3%FY 2022: 57.7%FY 2023: 135.0%FY 2024: -395.3%FY 2025: 111.8%
FY 2016 FY 2025
Free Cash Flow 46.2%
FY 2016: -202.7%FY 2017: -31.4%FY 2018: -7.5%FY 2019: -19.7%FY 2020: -70.9%FY 2021: 25.2%FY 2022: 88.0%FY 2023: -326.8%FY 2024: 28.9%FY 2025: 46.2%
FY 2016 FY 2025

Financial Health

Current Ratio 7.6×
FY 2016: 1.7×FY 2017: 10.7×FY 2018: 9.4×FY 2019: 3.6×FY 2020: 9.7×FY 2021: 8.5×FY 2022: 5.0×FY 2023: 3.5×FY 2024: 2.2×FY 2025: 7.6×
FY 2016 5y median 5.0× FY 2025
Quick Ratio 7.6×
FY 2016: 1.7×FY 2017: 11.3×FY 2018: 10.1×FY 2019: 3.6×FY 2020: 9.7×FY 2021: 8.5×FY 2022: 5.2×FY 2023: 3.5×FY 2024: 2.2×FY 2025: 7.6×
FY 2016 5y median 5.2× FY 2025
Debt / Equity 0.0×
FY 2016: 0.0×FY 2017: 0.0×FY 2018: 0.0×FY 2019: 0.1×FY 2020: 0.1×FY 2021: 0.1×FY 2022: 0.1×FY 2023: 0.1×FY 2024: 0.1×FY 2025: 0.0×
FY 2016 5y median 0.1× FY 2025
Net Debt / EBITDA -4.2×
FY 2016: 0.3×FY 2017: 2.1×FY 2018: 0.8×FY 2019: 0.4×FY 2020: 1.0×FY 2021: 1.2×FY 2022: 2.4×FY 2023: -2.6×FY 2024: 0.7×FY 2025: -4.2×
FY 2016 5y median 0.7× FY 2025
Interest Coverage 0.0×
FY 2016: 0.0×FY 2017: -138×FY 2018: -141×FY 2019: 0.0×FY 2020: 0.0×FY 2021: -45.3×FY 2022: -16.2×FY 2023: 0.0×FY 2024: 0.0×FY 2025: 0.0×
FY 2016 5y median 0.0× FY 2025

Dividends

Dividend Yield 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025
Payout Ratio 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025

Annual · latest fiscal year ends 2025-12-31