Ionis Pharmaceuticals, Inc. IONS
Set alert
41.24 USD -2.28 -5.24%
At close · Nov 2
41.56 +0.32 +0.78%
After hours · Nov 2, 4:00 PM ET
41.19 Day range 43.70
41.19 52-week range 86.74
- YTD
- -47.87%
- 1 year
- -44.50%
- Open
- 43.66
- Prev close
- 43.52
- Mkt cap
- 6.85B
- Vol
- 2.56M
- Avg vol
- 3.14M
- EPS
- -3.48
- P/E
- 0.00
- Div yield
- 0.00%
More statistics
- Low
- 41.19
- High
- 43.70
- Forward P/E
- -35.98
- Beta
- 0.40
- Short ratio
- 5.20
- Inst. own
- 110.24%
- Dividend
- 0.00
- Ex-div date
- Earnings
- Nov 4, 2026
- 50-d avg
- 49.02
- 200-d avg
- 66.79
- 1y target
- 84.13
MAX chart
Events in this range
- Nov 4, 2026Earnings: —; estimate -1.22; surprise —%
Signals (172)
| Name | Date | Ago |
|---|---|---|
| SMA: Bearish | Sep 1, 2026 | 2 months ago |
| SMA: Bullish | Aug 1, 2026 | 3 months ago |
| SMA: Bearish | Jul 1, 2026 | 4 months ago |
| SMA: Bearish | Jul 1, 2026 | 4 months ago |
| MACD: Sell Signal | Jul 1, 2026 | 4 months ago |
| RSI: Overbought | Sep 1, 2025 | 1 year ago |
| SMA: Bullish | Jul 1, 2025 | 1 year ago |
| MACD: Buy Signal | Jul 1, 2025 | 1 year ago |
| SMA: Bullish | Jun 1, 2025 | 1 year ago |
| SMA: Bearish | Sep 1, 2024 | 2 years ago |
| SMA: Bearish | Sep 1, 2024 | 2 years ago |
| MACD: Sell Signal | Sep 1, 2024 | 2 years ago |
| SMA: Bullish | Jun 1, 2024 | 2 years ago |
| SMA: Bullish | Jun 1, 2024 | 2 years ago |
| MACD: Buy Signal | Jun 1, 2024 | 2 years ago |
| SMA: Bearish | May 1, 2024 | 2 years ago |
| MACD: Sell Signal | May 1, 2024 | 2 years ago |
| SMA: Bearish | Mar 1, 2024 | 2 years ago |
| SMA: Bullish | May 1, 2023 | 3 years ago |
| SMA: Bullish | May 1, 2023 | 3 years ago |
| SMA: Bearish | Feb 1, 2023 | 3 years ago |
| SMA: Bullish | Jan 1, 2023 | 3 years ago |
| SMA: Bearish | Dec 1, 2022 | 3 years ago |
| SMA: Bearish | Nov 1, 2022 | 4 years ago |
| SMA: Bullish | Sep 1, 2022 | 4 years ago |
| MACD: Buy Signal | May 1, 2022 | 4 years ago |
| SMA: Bullish | Mar 1, 2022 | 4 years ago |
| SMA: Bearish | Feb 1, 2021 | 5 years ago |
| SMA: Bearish | Feb 1, 2021 | 5 years ago |
| SMA: Bullish | Jan 1, 2021 | 5 years ago |
| SMA: Bullish | Dec 1, 2020 | 5 years ago |
| SMA: Bearish | Aug 1, 2020 | 6 years ago |
| SMA: Bearish | Aug 1, 2020 | 6 years ago |
| SMA: Bullish | Jun 1, 2020 | 6 years ago |
| SMA: Bullish | May 1, 2020 | 6 years ago |
| SMA: Bearish | Feb 1, 2020 | 6 years ago |
| MACD: Sell Signal | Oct 1, 2019 | 7 years ago |
| SMA: Bearish | Aug 1, 2019 | 7 years ago |
| MACD: Buy Signal | Nov 1, 2018 | 8 years ago |
| SMA: Bullish | Sep 1, 2018 | 8 years ago |
| SMA: Bullish | Jul 1, 2018 | 8 years ago |
| SMA: Bearish | Jun 1, 2018 | 8 years ago |
| SMA: Bullish | May 1, 2018 | 8 years ago |
| SMA: Bearish | Mar 1, 2018 | 8 years ago |
| SMA: Bearish | Mar 1, 2018 | 8 years ago |
| MACD: Sell Signal | Mar 1, 2018 | 8 years ago |
| SMA: Bullish | Jan 1, 2018 | 8 years ago |
| SMA: Bearish | Dec 1, 2017 | 8 years ago |
| SMA: Bullish | Jun 1, 2017 | 9 years ago |
| SMA: Bearish | May 1, 2017 | 9 years ago |
| SMA: Bullish | Apr 1, 2017 | 9 years ago |
| SMA: Bearish | Mar 1, 2017 | 9 years ago |
| SMA: Bullish | Feb 1, 2017 | 9 years ago |
| SMA: Bearish | Jan 1, 2017 | 9 years ago |
| MACD: Buy Signal | Jan 1, 2017 | 9 years ago |
| SMA: Bullish | Dec 1, 2016 | 9 years ago |
| SMA: Bullish | Nov 1, 2016 | 10 years ago |
| SMA: Bearish | Oct 1, 2016 | 10 years ago |
| SMA: Bullish | Sep 1, 2016 | 10 years ago |
| SMA: Bearish | Jan 1, 2016 | 10 years ago |
| SMA: Bearish | Jan 1, 2016 | 10 years ago |
| SMA: Bullish | Nov 1, 2015 | 11 years ago |
| SMA: Bullish | Oct 1, 2015 | 11 years ago |
| SMA: Bearish | Sep 1, 2015 | 11 years ago |
| MACD: Sell Signal | Jul 1, 2015 | 11 years ago |
| SMA: Bearish | Jun 1, 2015 | 11 years ago |
| RSI: Overbought | Dec 1, 2014 | 11 years ago |
| MACD: Buy Signal | Nov 1, 2014 | 12 years ago |
| SMA: Bullish | Aug 1, 2014 | 12 years ago |
| MACD: Sell Signal | May 1, 2014 | 12 years ago |
| SMA: Bearish | Apr 1, 2014 | 12 years ago |
| RSI: Overbought | Apr 1, 2013 | 13 years ago |
| SMA: Bullish | Jan 1, 2013 | 13 years ago |
| SMA: Bullish | Dec 1, 2012 | 13 years ago |
| SMA: Bearish | Oct 1, 2012 | 14 years ago |
| SMA: Bearish | Oct 1, 2012 | 14 years ago |
| SMA: Bullish | May 1, 2012 | 14 years ago |
| SMA: Bullish | Feb 1, 2012 | 14 years ago |
| MACD: Buy Signal | Jan 1, 2012 | 14 years ago |
| MACD: Sell Signal | Aug 1, 2011 | 15 years ago |
| SMA: Bearish | Jun 1, 2011 | 15 years ago |
| SMA: Bullish | Apr 1, 2011 | 15 years ago |
| MACD: Buy Signal | Apr 1, 2011 | 15 years ago |
| SMA: Bearish | Jan 1, 2011 | 15 years ago |
| SMA: Bullish | Nov 1, 2010 | 16 years ago |
| SMA: Bearish | Oct 1, 2009 | 17 years ago |
| SMA: Bearish | Sep 1, 2009 | 17 years ago |
| MACD: Sell Signal | Sep 1, 2009 | 17 years ago |
| MACD: Buy Signal | Jul 1, 2009 | 17 years ago |
| SMA: Bullish | Jun 1, 2009 | 17 years ago |
| SMA: Bearish | May 1, 2009 | 17 years ago |
| SMA: Bullish | Mar 1, 2009 | 17 years ago |
| SMA: Bullish | Mar 1, 2009 | 17 years ago |
| SMA: Bearish | Feb 1, 2009 | 17 years ago |
| SMA: Bullish | Dec 1, 2008 | 17 years ago |
| SMA: Bearish | Nov 1, 2008 | 18 years ago |
| SMA: Bearish | Oct 1, 2008 | 18 years ago |
| MACD: Sell Signal | Oct 1, 2008 | 18 years ago |
| MACD: Buy Signal | Aug 1, 2008 | 18 years ago |
| SMA: Bullish | Jul 1, 2008 | 18 years ago |
| MACD: Sell Signal | Apr 1, 2008 | 18 years ago |
| SMA: Bearish | Mar 1, 2008 | 18 years ago |
| RSI: Overbought | Sep 1, 2007 | 19 years ago |
| SMA: Bullish | Aug 1, 2006 | 20 years ago |
| SMA: Bearish | Jun 1, 2006 | 20 years ago |
| SMA: Bullish | Feb 1, 2006 | 20 years ago |
| SMA: Bullish | Jul 1, 2005 | 21 years ago |
| MACD: Buy Signal | Jul 1, 2005 | 21 years ago |
| MACD: Sell Signal | Mar 1, 2005 | 21 years ago |
| SMA: Bearish | Jan 1, 2005 | 21 years ago |
| SMA: Bullish | Dec 1, 2004 | 21 years ago |
| MACD: Buy Signal | Dec 1, 2004 | 21 years ago |
| MACD: Sell Signal | Nov 1, 2004 | 22 years ago |
| SMA: Bearish | May 1, 2004 | 22 years ago |
| MACD: Buy Signal | Oct 1, 2003 | 23 years ago |
| SMA: Bullish | Aug 1, 2003 | 23 years ago |
| SMA: Bearish | Apr 1, 2002 | 24 years ago |
| MACD: Sell Signal | Apr 1, 2002 | 24 years ago |
| SMA: Bearish | Feb 1, 2002 | 24 years ago |
| SMA: Bullish | May 1, 2001 | 25 years ago |
| MACD: Buy Signal | May 1, 2001 | 25 years ago |
| SMA: Bullish | Apr 1, 2001 | 25 years ago |
| MACD: Sell Signal | Mar 1, 2001 | 25 years ago |
| SMA: Bearish | Feb 1, 2001 | 25 years ago |
| SMA: Bearish | Feb 1, 2001 | 25 years ago |
| SMA: Bullish | Jan 1, 2001 | 25 years ago |
| SMA: Bullish | Jan 1, 2001 | 25 years ago |
| MACD: Buy Signal | Jan 1, 2001 | 25 years ago |
| MACD: Sell Signal | Nov 1, 2000 | 26 years ago |
| SMA: Bearish | Oct 1, 2000 | 26 years ago |
| SMA: Bearish | Oct 1, 2000 | 26 years ago |
| SMA: Bullish | Aug 1, 2000 | 26 years ago |
| SMA: Bullish | Aug 1, 2000 | 26 years ago |
| SMA: Bearish | Jul 1, 2000 | 26 years ago |
| SMA: Bearish | Jul 1, 2000 | 26 years ago |
| SMA: Bullish | Jun 1, 2000 | 26 years ago |
| SMA: Bullish | Jun 1, 2000 | 26 years ago |
| SMA: Bearish | Apr 1, 2000 | 26 years ago |
| SMA: Bearish | Apr 1, 2000 | 26 years ago |
| SMA: Bullish | Feb 1, 2000 | 26 years ago |
| SMA: Bullish | Feb 1, 2000 | 26 years ago |
| MACD: Buy Signal | Feb 1, 2000 | 26 years ago |
| SMA: Bearish | Dec 1, 1999 | 26 years ago |
| SMA: Bearish | Dec 1, 1999 | 26 years ago |
| MACD: Sell Signal | Dec 1, 1999 | 26 years ago |
| SMA: Bullish | Nov 1, 1999 | 27 years ago |
| MACD: Buy Signal | Oct 1, 1999 | 27 years ago |
| SMA: Bullish | Sep 1, 1999 | 27 years ago |
| SMA: Bearish | Mar 1, 1999 | 27 years ago |
| SMA: Bullish | Dec 1, 1998 | 27 years ago |
| SMA: Bearish | Apr 1, 1998 | 28 years ago |
| SMA: Bearish | Apr 1, 1998 | 28 years ago |
| SMA: Bullish | Mar 1, 1998 | 28 years ago |
| SMA: Bullish | Mar 1, 1998 | 28 years ago |
| SMA: Bearish | Dec 1, 1997 | 28 years ago |
| SMA: Bearish | Nov 1, 1997 | 29 years ago |
| SMA: Bullish | Sep 1, 1997 | 29 years ago |
| SMA: Bullish | Aug 1, 1997 | 29 years ago |
| SMA: Bearish | Jul 1, 1997 | 29 years ago |
| MACD: Sell Signal | Apr 1, 1997 | 29 years ago |
| SMA: Bearish | Mar 1, 1997 | 29 years ago |
| SMA: Bullish | Sep 1, 1996 | 30 years ago |
| SMA: Bearish | Aug 1, 1996 | 30 years ago |
| RSI: Overbought | Jun 1, 1996 | 30 years ago |
| SMA: Bullish | Apr 1, 1996 | 30 years ago |
| SMA: Bearish | Mar 1, 1996 | 30 years ago |
| SMA: Bullish | Mar 1, 1995 | 31 years ago |
| SMA: Bullish | Jan 1, 1995 | 31 years ago |
| SMA: Bearish | May 1, 1994 | 32 years ago |
| SMA: Bullish | Oct 1, 1993 | 33 years ago |
| SMA: Bearish | Jan 1, 1993 | 33 years ago |
| SMA: Bullish | Nov 1, 1992 | 34 years ago |
Financial health
Altman Z-Score
0.89 Distress zone
Bankruptcy-risk model: below 1.81 distress, above 2.99 safe.
Piotroski F-Score
2 / 9 Weak
Nine pass/fail tests of profitability, leverage and efficiency.
FMP rating
D+1 / 5 overall
- DCF 1
- Return on Equity 1
- Return on Assets 1
- Debt / Equity 1
- P/E 1
- P/B 1
Valuation
P/E -33.2×
FY 2016 5y median -19.9× FY 2025
P/S 13.4×
FY 2016 5y median 9.1× FY 2025
P/B 25.9×
FY 2016 5y median 9.4× FY 2025
P/FCF -39.6×
FY 2016 5y median -18.2× FY 2025
EV/EBITDA -52.4×
FY 2016 5y median -35.1× FY 2025
EV/Sales 15.8×
FY 2016 5y median 10.5× FY 2025
FCF Yield -2.5%
FY 2016 5y median -4.6% FY 2025
Profitability
Gross Margin 98.3%
FY 2016 5y median 98.4% FY 2025
Operating Margin -40.5%
FY 2016 5y median -44.9% FY 2025
Net Margin -40.4%
FY 2016 5y median -45.9% FY 2025
ROE -77.9%
FY 2016 5y median -77.1% FY 2025
ROIC -12.0%
FY 2016 5y median -13.6% FY 2025
ROA -10.8%
FY 2016 5y median -10.8% FY 2025
Growth (YoY)
Revenue 33.9%
FY 2016 FY 2025
Operating Income 19.6%
FY 2016 FY 2025
EPS (diluted) 21.7%
FY 2016 FY 2025
Free Cash Flow 41.4%
FY 2016 FY 2025
Financial Health
Current Ratio 3.8×
FY 2016 5y median 7.1× FY 2025
Quick Ratio 3.8×
FY 2016 5y median 7.0× FY 2025
Debt / Equity 5.3×
FY 2016 5y median 2.4× FY 2025
Net Debt / EBITDA -7.9×
FY 2016 5y median -4.8× FY 2025
Interest Coverage -4.2×
FY 2016 5y median -4.3× FY 2025
Dividends
Dividend Yield 0.0%
FY 2016 5y median 0.0% FY 2025
Payout Ratio 0.0%
FY 2016 5y median 0.0% FY 2025
Annual · latest fiscal year ends 2025-12-31