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Ionis Pharmaceuticals, Inc. IONS

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40.15 USD -0.27 (-0.67%)

At closeNov 4, 2026, 4:00 PM EST

40.15 0.00 0.00%

After hours · Nov 4, 4:00 PM ET

39.33 Day range 41.53
39.33 52-week range 86.74
YTD
-49.25%
1 year
-44.91%

Financial health

Altman Z-Score

0.86 Distress zone

Bankruptcy-risk model: below 1.81 distress, above 2.99 safe.

Piotroski F-Score

2 / 9 Weak

Nine pass/fail tests of profitability, leverage and efficiency.

FMP rating

D+1 / 5 overall

  • DCF 1
  • Return on Equity 1
  • Return on Assets 1
  • Debt / Equity 1
  • P/E 1
  • P/B 1

Valuation

P/E -33.2×
FY 2016: -66.4×FY 2017: 335×FY 2018: 26.1×FY 2019: 28.8×FY 2020: -17.8×FY 2021: -152×FY 2022: -19.9×FY 2023: -19.8×FY 2024: -11.5×FY 2025: -33.2×
FY 2016 5y median -19.9× FY 2025
P/S 13.4×
FY 2016: 15.5×FY 2017: 12.1×FY 2018: 11.9×FY 2019: 7.5×FY 2020: 10.8×FY 2021: 5.3×FY 2022: 9.1×FY 2023: 9.2×FY 2024: 7.4×FY 2025: 13.4×
FY 2016 5y median 9.1× FY 2025
P/B 25.9×
FY 2016: 58.0×FY 2017: 22.2×FY 2018: 6.8×FY 2019: 5.7×FY 2020: 10.6×FY 2021: 5.6×FY 2022: 9.4×FY 2023: 18.7×FY 2024: 8.9×FY 2025: 25.9×
FY 2016 5y median 9.4× FY 2025
P/FCF -39.6×
FY 2016: -46.7×FY 2017: 45.8×FY 2018: 12.2×FY 2019: 27.3×FY 2020: -1531×FY 2021: 333×FY 2022: -18.2×FY 2023: -21.6×FY 2024: -9.6×FY 2025: -39.6×
FY 2016 5y median -18.2× FY 2025
EV/EBITDA -52.4×
FY 2016: -650×FY 2017: 184×FY 2018: -399×FY 2019: 23.3×FY 2020: -75.6×FY 2021: -901×FY 2022: -28.3×FY 2023: -35.1×FY 2024: -18.1×FY 2025: -52.4×
FY 2016 5y median -35.1× FY 2025
EV/Sales 15.8×
FY 2016: 16.8×FY 2017: 13.0×FY 2018: 12.5×FY 2019: 7.6×FY 2020: 11.5×FY 2021: 5.8×FY 2022: 11.0×FY 2023: 10.5×FY 2024: 9.1×FY 2025: 15.8×
FY 2016 5y median 10.5× FY 2025
FCF Yield -2.5%
FY 2016: -2.1%FY 2017: 2.2%FY 2018: 8.2%FY 2019: 3.7%FY 2020: -0.1%FY 2021: 0.3%FY 2022: -5.5%FY 2023: -4.6%FY 2024: -10.5%FY 2025: -2.5%
FY 2016 5y median -4.6% FY 2025

Profitability

Gross Margin 98.3%
FY 2016: 100.0%FY 2017: 100.0%FY 2018: 99.7%FY 2019: 99.6%FY 2020: 98.4%FY 2021: 98.7%FY 2022: 97.6%FY 2023: 98.8%FY 2024: 98.4%FY 2025: 98.3%
FY 2016 5y median 98.4% FY 2025
Operating Margin -40.5%
FY 2016: -5.4%FY 2017: 6.0%FY 2018: -10.2%FY 2019: 32.6%FY 2020: -23.6%FY 2021: -3.7%FY 2022: -69.8%FY 2023: -44.9%FY 2024: -67.4%FY 2025: -40.5%
FY 2016 5y median -44.9% FY 2025
Net Margin -40.4%
FY 2016: -16.2%FY 2017: 0.1%FY 2018: 45.6%FY 2019: 24.8%FY 2020: -60.9%FY 2021: -3.5%FY 2022: -45.9%FY 2023: -46.5%FY 2024: -64.4%FY 2025: -40.4%
FY 2016 5y median -45.9% FY 2025
ROE -77.9%
FY 2016: -60.7%FY 2017: 0.1%FY 2018: 26.1%FY 2019: 18.9%FY 2020: -59.8%FY 2021: -3.7%FY 2022: -47.1%FY 2023: -94.7%FY 2024: -77.1%FY 2025: -77.9%
FY 2016 5y median -77.1% FY 2025
ROIC -12.0%
FY 2016: -2.6%FY 2017: 1.8%FY 2018: 7.2%FY 2019: 10.5%FY 2020: -8.2%FY 2021: -1.2%FY 2022: -18.4%FY 2023: -13.6%FY 2024: -17.3%FY 2025: -12.0%
FY 2016 5y median -13.6% FY 2025
ROA -10.8%
FY 2016: -6.6%FY 2017: 0.0%FY 2018: 10.3%FY 2019: 8.6%FY 2020: -18.6%FY 2021: -1.1%FY 2022: -10.6%FY 2023: -12.3%FY 2024: -15.1%FY 2025: -10.8%
FY 2016 5y median -10.8% FY 2025

Growth (YoY)

Revenue 33.9%
FY 2016: 31.4%FY 2017: 37.9%FY 2018: 16.6%FY 2019: 87.2%FY 2020: -35.0%FY 2021: 11.1%FY 2022: -27.5%FY 2023: 34.1%FY 2024: -10.5%FY 2025: 33.9%
FY 2016 FY 2025
Operating Income 19.6%
FY 2016: 73.4%FY 2017: 254.0%FY 2018: -297.7%FY 2019: 696.2%FY 2020: -147.0%FY 2021: 82.5%FY 2022: -1258.9%FY 2023: 13.8%FY 2024: -34.3%FY 2025: 19.6%
FY 2016 FY 2025
EPS (diluted) 21.7%
FY 2016: 2.7%FY 2017: 120.8%FY 2018: 1260.0%FY 2019: 1.0%FY 2020: -254.4%FY 2021: 93.7%FY 2022: -850.0%FY 2023: -34.7%FY 2024: -18.8%FY 2025: 21.7%
FY 2016 FY 2025
Free Cash Flow 41.4%
FY 2016: -1418.5%FY 2017: 210.2%FY 2018: 329.4%FY 2019: -47.1%FY 2020: -101.7%FY 2021: 350.2%FY 2022: -2383.1%FY 2023: -13.9%FY 2024: -62.8%FY 2025: 41.4%
FY 2016 FY 2025

Financial Health

Current Ratio 3.8×
FY 2016: 6.0×FY 2017: 4.8×FY 2018: 7.9×FY 2019: 10.0×FY 2020: 3.6×FY 2021: 9.7×FY 2022: 7.1×FY 2023: 5.9×FY 2024: 8.5×FY 2025: 3.8×
FY 2016 5y median 7.1× FY 2025
Quick Ratio 3.8×
FY 2016: 5.9×FY 2017: 4.8×FY 2018: 7.8×FY 2019: 9.9×FY 2020: 3.5×FY 2021: 9.6×FY 2022: 7.0×FY 2023: 5.9×FY 2024: 8.4×FY 2025: 3.8×
FY 2016 5y median 7.0× FY 2025
Debt / Equity 5.3×
FY 2016: 5.8×FY 2017: 2.1×FY 2018: 0.6×FY 2019: 0.5×FY 2020: 1.2×FY 2021: 1.6×FY 2022: 2.4×FY 2023: 3.8×FY 2024: 2.4×FY 2025: 5.3×
FY 2016 5y median 2.4× FY 2025
Net Debt / EBITDA -7.9×
FY 2016: -50.8×FY 2017: 12.8×FY 2018: -19.3×FY 2019: 0.2×FY 2020: -4.6×FY 2021: -73.6×FY 2022: -4.8×FY 2023: -4.5×FY 2024: -3.3×FY 2025: -7.9×
FY 2016 5y median -4.8× FY 2025
Interest Coverage -4.2×
FY 2016: -0.5×FY 2017: 0.7×FY 2018: -1.4×FY 2019: 7.5×FY 2020: -18.1×FY 2021: -3.2×FY 2022: -50.5×FY 2023: -4.3×FY 2024: -5.3×FY 2025: -4.2×
FY 2016 5y median -4.3× FY 2025

Dividends

Dividend Yield 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025
Payout Ratio 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025

Annual · latest fiscal year ends 2025-12-31