Spyre Therapeutics, Inc. SYRE
Set alert
96.56 USD -2.40 -2.43%
At close · Oct 30
96.45 -0.11 -0.11%
After hours · Oct 30, 4:00 PM ET
94.68 Day range 98.96
22.18 52-week range 108.92
- YTD
- +194.75%
- 1 year
- +298.02%
- Open
- 96.78
- Prev close
- 98.96
- Mkt cap
- 9.02B
- Vol
- 661.13K
- Avg vol
- 1.21M
- EPS
- -1.92
- P/E
- 0.00
- Div yield
- 0.00%
More statistics
- Low
- 94.68
- High
- 98.96
- Forward P/E
- -27.55
- Beta
- 3.11
- Short ratio
- 7.98
- Inst. own
- 108.53%
- Dividend
- 0.00
- Ex-div date
- Earnings
- Nov 3, 2026
- 50-d avg
- 90.28
- 200-d avg
- 72.91
- 1y target
- 122.33
5D chart
Signals (103)
| Name | Time | Ago |
|---|---|---|
| SMA: Bearish | Oct 30, 9:30 AM | 1 day ago |
| SMA: Bearish | Oct 30, 9:30 AM | 1 day ago |
| MACD: Sell Signal | Oct 30, 9:30 AM | 1 day ago |
| SMA: Bullish | Oct 29, 3:30 PM | 2 days ago |
| SMA: Bullish | Oct 29, 3:25 PM | 2 days ago |
| SMA: Bearish | Oct 29, 3:15 PM | 2 days ago |
| SMA: Bullish | Oct 29, 3:00 PM | 2 days ago |
| MACD: Buy Signal | Oct 29, 3:00 PM | 2 days ago |
| SMA: Bearish | Oct 29, 2:55 PM | 2 days ago |
| SMA: Bullish | Oct 29, 2:45 PM | 2 days ago |
| RSI: Oversold | Oct 29, 2:35 PM | 2 days ago |
| RSI: Oversold | Oct 29, 2:10 PM | 2 days ago |
| MACD: Sell Signal | Oct 29, 1:30 PM | 2 days ago |
| SMA: Bearish | Oct 29, 1:25 PM | 2 days ago |
| SMA: Bullish | Oct 29, 1:15 PM | 2 days ago |
| MACD: Buy Signal | Oct 29, 1:15 PM | 2 days ago |
| SMA: Bearish | Oct 29, 1:10 PM | 2 days ago |
| MACD: Sell Signal | Oct 29, 1:10 PM | 2 days ago |
| MACD: Buy Signal | Oct 29, 1:00 PM | 2 days ago |
| SMA: Bullish | Oct 29, 12:55 PM | 2 days ago |
| SMA: Bearish | Oct 29, 12:30 PM | 2 days ago |
| SMA: Bullish | Oct 29, 12:20 PM | 2 days ago |
| SMA: Bearish | Oct 29, 11:40 AM | 2 days ago |
| SMA: Bearish | Oct 29, 11:40 AM | 2 days ago |
| MACD: Sell Signal | Oct 29, 11:40 AM | 2 days ago |
| MACD: Buy Signal | Oct 29, 11:20 AM | 2 days ago |
| SMA: Bullish | Oct 29, 11:05 AM | 2 days ago |
| SMA: Bullish | Oct 29, 11:05 AM | 2 days ago |
| SMA: Bearish | Oct 29, 10:45 AM | 2 days ago |
| MACD: Sell Signal | Oct 29, 10:30 AM | 2 days ago |
| SMA: Bearish | Oct 29, 10:25 AM | 2 days ago |
| SMA: Bullish | Oct 29, 10:15 AM | 2 days ago |
| SMA: Bearish | Oct 29, 10:05 AM | 2 days ago |
| SMA: Bullish | Oct 29, 10:00 AM | 2 days ago |
| SMA: Bearish | Oct 29, 9:55 AM | 2 days ago |
| MACD: Buy Signal | Oct 28, 3:40 PM | 3 days ago |
| SMA: Bullish | Oct 28, 3:30 PM | 3 days ago |
| SMA: Bullish | Oct 28, 3:30 PM | 3 days ago |
| SMA: Bearish | Oct 28, 3:10 PM | 3 days ago |
| MACD: Sell Signal | Oct 28, 3:05 PM | 3 days ago |
| SMA: Bearish | Oct 28, 2:50 PM | 3 days ago |
| SMA: Bullish | Oct 28, 2:05 PM | 3 days ago |
| SMA: Bullish | Oct 28, 1:55 PM | 3 days ago |
| SMA: Bearish | Oct 28, 1:40 PM | 3 days ago |
| MACD: Buy Signal | Oct 28, 1:20 PM | 3 days ago |
| SMA: Bullish | Oct 28, 1:15 PM | 3 days ago |
| SMA: Bearish | Oct 28, 1:10 PM | 3 days ago |
| SMA: Bullish | Oct 28, 1:05 PM | 3 days ago |
| RSI: Oversold | Oct 28, 12:45 PM | 3 days ago |
| SMA: Bearish | Oct 28, 11:45 AM | 3 days ago |
| SMA: Bearish | Oct 28, 11:25 AM | 3 days ago |
| MACD: Sell Signal | Oct 28, 11:25 AM | 3 days ago |
| SMA: Bullish | Oct 28, 11:10 AM | 3 days ago |
| SMA: Bearish | Oct 28, 11:05 AM | 3 days ago |
| MACD: Buy Signal | Oct 28, 10:45 AM | 3 days ago |
| SMA: Bullish | Oct 28, 10:15 AM | 3 days ago |
| SMA: Bullish | Oct 28, 10:00 AM | 3 days ago |
| SMA: Bearish | Oct 28, 9:55 AM | 3 days ago |
| MACD: Sell Signal | Oct 28, 9:45 AM | 3 days ago |
| SMA: Bearish | Oct 28, 9:40 AM | 3 days ago |
| RSI: Overbought | Oct 27, 3:55 PM | 4 days ago |
| RSI: Overbought | Oct 27, 3:30 PM | 4 days ago |
| MACD: Buy Signal | Oct 27, 2:55 PM | 4 days ago |
| SMA: Bullish | Oct 27, 2:25 PM | 4 days ago |
| SMA: Bullish | Oct 27, 2:25 PM | 4 days ago |
| SMA: Bearish | Oct 27, 2:05 PM | 4 days ago |
| SMA: Bearish | Oct 27, 2:05 PM | 4 days ago |
| SMA: Bullish | Oct 27, 2:00 PM | 4 days ago |
| SMA: Bearish | Oct 27, 1:50 PM | 4 days ago |
| SMA: Bullish | Oct 27, 1:20 PM | 4 days ago |
| SMA: Bullish | Oct 27, 1:20 PM | 4 days ago |
| SMA: Bearish | Oct 27, 1:05 PM | 4 days ago |
| SMA: Bearish | Oct 27, 12:30 PM | 4 days ago |
| SMA: Bullish | Oct 27, 12:25 PM | 4 days ago |
| SMA: Bearish | Oct 27, 12:10 PM | 4 days ago |
| MACD: Sell Signal | Oct 27, 12:05 PM | 4 days ago |
| RSI: Overbought | Oct 27, 10:40 AM | 4 days ago |
| SMA: Bullish | Oct 27, 10:05 AM | 4 days ago |
| SMA: Bearish | Oct 27, 10:00 AM | 4 days ago |
| RSI: Overbought | Oct 27, 9:35 AM | 4 days ago |
| SMA: Bullish | Oct 26, 3:40 PM | 5 days ago |
| SMA: Bullish | Oct 26, 3:30 PM | 5 days ago |
| MACD: Buy Signal | Oct 26, 3:30 PM | 5 days ago |
| RSI: Oversold | Oct 26, 3:00 PM | 5 days ago |
| SMA: Bearish | Oct 26, 1:25 PM | 5 days ago |
| SMA: Bearish | Oct 26, 1:15 PM | 5 days ago |
| SMA: Bullish | Oct 26, 1:10 PM | 5 days ago |
| SMA: Bullish | Oct 26, 1:10 PM | 5 days ago |
| SMA: Bearish | Oct 26, 1:00 PM | 5 days ago |
| SMA: Bullish | Oct 26, 12:55 PM | 5 days ago |
| SMA: Bearish | Oct 26, 12:40 PM | 5 days ago |
| SMA: Bearish | Oct 26, 12:20 PM | 5 days ago |
| SMA: Bullish | Oct 26, 12:10 PM | 5 days ago |
| SMA: Bearish | Oct 26, 12:05 PM | 5 days ago |
| SMA: Bullish | Oct 26, 12:00 PM | 5 days ago |
| SMA: Bearish | Oct 26, 11:45 AM | 5 days ago |
| RSI: Overbought | Oct 26, 11:10 AM | 5 days ago |
| SMA: Bullish | Oct 26, 11:05 AM | 5 days ago |
| SMA: Bearish | Oct 26, 10:55 AM | 5 days ago |
| SMA: Bullish | Oct 26, 10:50 AM | 5 days ago |
| SMA: Bearish | Oct 26, 10:40 AM | 5 days ago |
| SMA: Bullish | Oct 26, 10:35 AM | 5 days ago |
| SMA: Bearish | Oct 26, 10:30 AM | 5 days ago |
Ownership
Held by insiders 1.58%
Held by institutions 108.53%
Float held by institutions 110.28%
Institutions 393
Top institutional holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| FMR, LLC | 12.78% | 13,026,187 | 1.26B | Jun 29, 2026 |
| Blackrock Inc. | 6.38% | 6,506,605 | 628.28M | Jun 29, 2026 |
| Perceptive Advisors Llc | 4.24% | 4,319,496 | 417.09M | Jun 29, 2026 |
| RTW Investments LP | 4.17% | 4,251,996 | 410.57M | Jun 29, 2026 |
| Paradigm Biocapital Advisors LP | 3.77% | 3,840,778 | 370.87M | Jun 29, 2026 |
| Vanguard Capital Management LLC | 3.38% | 3,448,681 | 333.00M | Jun 29, 2026 |
Top mutual fund holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| Fidelity Mt. Vernon Street Trust-Fidelity Growth Company Fund | 2.71% | 2,760,132 | 266.52M | Aug 30, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 2.44% | 2,482,298 | 239.69M | Jun 29, 2026 |
| SmallCap World Fund Inc | 2.21% | 2,247,758 | 217.04M | Sep 29, 2026 |
| iShares Trust-iShares Russell 2000 ETF | 1.95% | 1,982,310 | 191.41M | Sep 29, 2026 |
| SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF | 1.67% | 1,699,846 | 164.14M | Sep 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund | 0.88% | 896,559 | 86.57M | Jun 29, 2026 |
Insiders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| ALBERS JEFFREY W | Director | Sale | Aug 6, 2026 | 0 |
| BURROWS SCOTT L. | Chief Financial Officer | Sale | Sep 1, 2026 | 79,762 |
| FAIRMOUNT FUNDS MANAGEMENT LLC | Unknown | Sale | Jun 22, 2026 | 0 |
| HENDERSON MICHAEL THOMAS | Director | Sale | Jun 21, 2026 | 68,606 |
| KING-JONES HEIDY | Officer | Sale | Sep 1, 2026 | 2,845 |
| SLOAN SHELDON | Officer | Sale | Jun 30, 2026 | 0 |
Held by funds
144 US ETFs and mutual funds hold SYRE · largest positions