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SYRE
Spyre Therapeutics, Inc.
85.69
2 x 61.34
2 x 102.93
bid
ask
+
5.79
7.25%
2 @ 04:00 PM
85.69 +0.00 (0.00%)
Ytd161.57%
1y304.77%
78.73
day range
86.22
18.92
52 week range
108.92
Open79.90Prev Close79.90Low78.73High86.22Mkt Cap7.91B
Vol1.12MAvg Vol1.22MEPS-2.06P/EN/AForward P/E-24.34
Beta3.11Short Ratio10.44Inst. Own106.80%DividendN/ADiv YieldN/A
Ex Div DateN/AEarning11-0350-d Avg94.65200-d Avg68.631yr Est120.21

SYRE News

Spyre: Maintain 'Strong Buy' On Additional SPY072 Shots On Goal Q4 2026 And IBD Combination Potential
seekingalpha.com
Spyre: Maintain 'Strong Buy' On Additional SPY072 Shots On Goal Q4 2026 And IBD Combination Potentia

Spyre Therapeutics maintains a 'Strong Buy' rating, driven by promising IBD pipeline progress and ro

Crude Oil Edges Lower; Lamb Weston Shares Surge Following Upbeat Q1 Earnings
benzinga.com
Crude Oil Edges Lower; Lamb Weston Shares Surge Following Upbeat Q1 Earnings

U.S. stocks rose Tuesday: Dow +350 points, S&P 500 +0.86%. Lamb Weston jumped 12% on strong resu

Spyre Therapeutics Announces Pricing of $350.0 Million Public Offering of Common Stock
globenewswire.com
Spyre Therapeutics Announces Pricing of $350.0 Million Public Offering of Common Stock

WALTHAM, Mass., Oct. 05, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (“Spyre” or the “Company”

Spyre Therapeutics Announces Proposed Public Offering of its Common Stock
globenewswire.com
Spyre Therapeutics Announces Proposed Public Offering of its Common Stock

WALTHAM, Mass., Oct. 05, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (“Spyre” or the “Company”

Spyre (NASDAQ: SYRE) legal chief trims stake in planned share sale
defenseworld.net
Spyre (NASDAQ: SYRE) legal chief trims stake in planned share sale

What happened Spyre Therapeutics, Inc. (NASDAQ: SYRE) Chief Legal Officer and Corporate Secretary He

Spyre Therapeutics Announces Grants of Inducement Awards
globenewswire.com
Spyre Therapeutics Announces Grants of Inducement Awards

WALTHAM, Mass., Oct. 02, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Comp

Spyre Therapeutics (NASDAQ:SYRE) Shares Gap Up – Should You Buy?
defenseworld.net
Spyre Therapeutics (NASDAQ:SYRE) Shares Gap Up – Should You Buy?

Spyre Therapeutics, Inc. (NASDAQ: SYRE - Get Free Report)'s stock price gapped up prior to trading o

benzinga.com
JP Morgan Initiates Coverage On Spyre Therapeutics with Overweight Rating, Announces Price Target of

JP Morgan analyst Hardik Parikh initiates coverage on Spyre Therapeutics (NASDAQ:SYRE) with a Ove

benzinga.com
BTIG Reiterates Buy on Spyre Therapeutics, Maintains $121 Price Target

BTIG analyst Julian Harrison reiterates Spyre Therapeutics (NASDAQ:SYRE) with a Buy and maintains

Hewlett Packard Enterprise, Capital Bancorp, FormFactor And Other Big Stocks Moving Higher On Wednesday
benzinga.com
Hewlett Packard Enterprise, Capital Bancorp, FormFactor And Other Big Stocks Moving Higher On Wednes

U.S. stocks rose as Nasdaq gained 100+ points; HPE jumped 5.1% on stronger networking guidance and a

Gain Therapeutics (NASDAQ:GANX) versus Spyre Therapeutics (NASDAQ:SYRE) Head to Head Comparison
defenseworld.net
Gain Therapeutics (NASDAQ:GANX) versus Spyre Therapeutics (NASDAQ:SYRE) Head to Head Comparison

Spyre Therapeutics (NASDAQ: SYRE - Get Free Report) and Gain Therapeutics (NASDAQ: GANX - Get Free R

California State Teachers Retirement System Buys 5,683,670 Shares of Spyre Therapeutics, Inc. $SYRE
defenseworld.net
California State Teachers Retirement System Buys 5,683,670 Shares of Spyre Therapeutics, Inc. $SYRE

California State Teachers Retirement System grew its stake in shares of Spyre Therapeutics, Inc. (NA

11,250 Shares in Spyre Therapeutics, Inc. $SYRE Acquired by VIRGINIA RETIREMENT SYSTEMS ET Al
defenseworld.net
11,250 Shares in Spyre Therapeutics, Inc. $SYRE Acquired by VIRGINIA RETIREMENT SYSTEMS ET Al

VIRGINIA RETIREMENT SYSTEMS ET Al purchased a new stake in Spyre Therapeutics, Inc. (NASDAQ: SYRE) d

Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcript
seekingalpha.com
Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcr

Spyre Therapeutics, Inc. (SYRE) Presents at Citigroup's Biopharma Back to School Summit 2026 Transcr

Spyre's Anti-IL-23 Antibody Meets Goal in Ulcerative Colitis Study
zacks.com
Spyre's Anti-IL-23 Antibody Meets Goal in Ulcerative Colitis Study

SYRE's SPY003 posts positive phase II UC data, strengthening Spyre's multi-mechanism IBD strategy.

benzinga.com
Wedbush Reiterates Outperform on Spyre Therapeutics, Maintains $123 Price Target

Wedbush analyst David Nierengarten reiterates Spyre Therapeutics (NASDAQ:SYRE) with a Outperform

benzinga.com
BTIG Reiterates Buy on Spyre Therapeutics, Maintains $121 Price Target

BTIG analyst Julian Harrison reiterates Spyre Therapeutics (NASDAQ:SYRE) with a Buy and maintains

benzinga.com
Spyre's SPY003 Met Its Primary Endpoint

SPY003 met its primary endpoint with a statistically significant reduction of 10.0 points (p<0.00

Spyre Announces Potential Best-in-Class SPY003 (anti-IL-23) Part A Induction Results from SKYLINE Trial, Completing Proof-of-Concept for All Three Components of its IBD Combinations
globenewswire.com
Spyre Announces Potential Best-in-Class SPY003 (anti-IL-23) Part A Induction Results from SKYLINE Tr

SPY003 met its primary endpoint with a statistically significant reduction of 10.0 points (p

Spyre Therapeutics Announces Grants of Inducement Awards
globenewswire.com
Spyre Therapeutics Announces Grants of Inducement Awards

WALTHAM, Mass., Sept. 04, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Com

Spyre Therapeutics to Participate in Upcoming September Investor Conferences
globenewswire.com
Spyre Therapeutics to Participate in Upcoming September Investor Conferences

WALTHAM, Mass., Sept. 03, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinic

Spyre Therapeutics (SYRE) Down 16.6% Since Last Earnings Report: Can It Rebound?
zacks.com
Spyre Therapeutics (SYRE) Down 16.6% Since Last Earnings Report: Can It Rebound?

Spyre Therapeutics (SYRE) reported earnings 30 days ago. What's next for the stock?

benzinga.com
Deutsche Bank Maintains Buy on Spyre Therapeutics, Lowers Price Target to $127

Deutsche Bank analyst David Hoang maintains Spyre Therapeutics (NASDAQ:SYRE) with a Buy and lower

SYRE Stock Sinks After Mixed SKYWAY Study Data in Rheumatoid Arthritis
zacks.com
SYRE Stock Sinks After Mixed SKYWAY Study Data in Rheumatoid Arthritis

Spyre's SPY072 shows activity in RA, but a smaller-than-expected benefit shifts its focus toward bro

Spyre Therapeutics Says Rheumatoid Arthritis Program Misses Internal Benchmark, Stock Tumbles
benzinga.com
Spyre Therapeutics Says Rheumatoid Arthritis Program Misses Internal Benchmark, Stock Tumbles

Spyre Therapeutics, Inc. (NASDAQ:SYRE) stock is trading lower on Wednesday after the company shared

Spyre Therapeutics Says Rheumatoid Arthritis Program Misses Internal Benchmark, Stock Tumbles
benzinga.com
Spyre Therapeutics Says Rheumatoid Arthritis Program Misses Internal Benchmark, Stock Tumbles

Spyre Therapeutics shared Phase 2 SKYWAY trial data for SPY072 in rheumatoid arthritis. The therapy

benzinga.com
Wedbush Maintains Outperform on Spyre Therapeutics, Lowers Price Target to $123

Wedbush analyst David Nierengarten maintains Spyre Therapeutics (NASDAQ:SYRE) with a Outperform a

12 Health Care Stocks Moving In Wednesday's Pre-Market Session
benzinga.com
12 Health Care Stocks Moving In Wednesday's Pre-Market Session

Gainers Nuwellis (NASDAQ:NUWE) stock increased by 27.2% to $1.22 during Wednesday's pre-market

Intuit, Zoom, Qfin Holdings And Other Big Stocks Moving Lower In Wednesday’s Pre-Market Session
benzinga.com
Intuit, Zoom, Qfin Holdings And Other Big Stocks Moving Lower In Wednesday’s Pre-Market Session

US stock futures mixed, Intuit shares dip 11.7% after reporting Q4 revenue of $4.35B and adjusted ea

benzinga.com
BTIG Maintains Buy on Spyre Therapeutics, Lowers Price Target to $121

BTIG analyst Julian Harrison maintains Spyre Therapeutics (NASDAQ:SYRE) with a Buy and lowers the

Why JOYY Shares Are Trading Higher; Here Are 20 Stocks Moving Premarket
benzinga.com
Why JOYY Shares Are Trading Higher; Here Are 20 Stocks Moving Premarket

JOYY Inc (NASDAQ: JOYY) reported Q2 earnings below estimates, but beat revenue expectations. Shares

12 Health Care Stocks Moving In Tuesday's After-Market Session
benzinga.com
12 Health Care Stocks Moving In Tuesday's After-Market Session

Gainers Alector (NASDAQ:ALEC) shares increased by 9.7% to $2.59 during Tuesday's after-market s

Spyre Therapeutics Announces Topline Results from the Rheumatoid Arthritis Sub-study of the SKYWAY Phase 2 Trial of SPY072
globenewswire.com
Spyre Therapeutics Announces Topline Results from the Rheumatoid Arthritis Sub-study of the SKYWAY P

Both doses of SPY072 demonstrated statistically significant benefits compared to placebo on one or m

Can Spyre's SPY772 HS Study Broaden Its Growth Story Beyond Core IBD?
zacks.com
Can Spyre's SPY772 HS Study Broaden Its Growth Story Beyond Core IBD?

SYRE expands into HS with SPY772, testing whether dual-pathway inhibition can strengthen outcomes in

Is SYRE a Buy Now as Clinical Catalysts Clash With Valuation Risk?
zacks.com
Is SYRE a Buy Now as Clinical Catalysts Clash With Valuation Risk?

Spyre has a broad clinical pipeline and cash runway, but elevated valuation makes upcoming readouts

Target To Rally Around 12%? Here Are 10 Top Analyst Forecasts For Tuesday
benzinga.com
Target To Rally Around 12%? Here Are 10 Top Analyst Forecasts For Tuesday

Wall Street analysts changed outlook on top names. See complete view of all changes, upgrades, downg

benzinga.com
BTIG Maintains Buy on Spyre Therapeutics, Raises Price Target to $132

BTIG analyst Julian Harrison maintains Spyre Therapeutics (NASDAQ:SYRE) with a Buy and raises the

benzinga.com
Spyre Therapeutics Launches New Combination Program SPY772, Comprising Long-Acting Anti-TL1A Antibod

To test the hypothesis of the SPY772 program, the company also announced the initiation of SKYLIGHT,

benzinga.com
Wells Fargo Maintains Overweight on Spyre Therapeutics, Raises Price Target to $115

Wells Fargo analyst Yanan Zhu maintains Spyre Therapeutics (NASDAQ:SYRE) with a Overweight and ra

benzinga.com
Guggenheim Maintains Buy on Spyre Therapeutics, Raises Price Target to $130

Guggenheim analyst Yatin Suneja maintains Spyre Therapeutics (NASDAQ:SYRE) with a Buy and raises

benzinga.com
Wedbush Maintains Outperform on Spyre Therapeutics, Raises Price Target to $130

Wedbush analyst David Nierengarten maintains Spyre Therapeutics (NASDAQ:SYRE) with a Outperform a

benzinga.com
Spyre Therapeutics Q2 EPS $(0.36) Beats $(0.73) Estimate

Spyre Therapeutics (NASDAQ:SYRE) reported quarterly losses of $(0.36) per share which beat the analy

Goldman Sachs Posts Upbeat Q2 Earnings, Joins SK Hynix, Tower Semiconductor And Other Big Stocks Moving Higher On Tuesday
benzinga.com
Goldman Sachs Posts Upbeat Q2 Earnings, Joins SK Hynix, Tower Semiconductor And Other Big Stocks Mov

Goldman Sachs (NYSE: GS) shares surged 6.9% after beating earnings estimates. Other big gainers incl

benzinga.com
Mizuho Maintains Outperform on Spyre Therapeutics, Raises Price Target to $120

Mizuho analyst Joseph Catanzaro maintains Spyre Therapeutics (NASDAQ:SYRE) with a Outperform and

Rivian, Micron And Other Big Stocks Moving Lower In Tuesday’s Pre-Market Session
benzinga.com
Rivian, Micron And Other Big Stocks Moving Lower In Tuesday’s Pre-Market Session

U.S. stock futures mixed, Nasdaq 100 falls 200 pts. Rivian (RIVN) drops after public offering announ

FedEx, Cerebras Systems And Other Big Stocks Moving Lower In Wednesday’s Pre-Market Session
benzinga.com
FedEx, Cerebras Systems And Other Big Stocks Moving Lower In Wednesday’s Pre-Market Session

U.S. stock futures mixed, Nasdaq 100 up 100 points. FedEx falls after Q4 results, beating estimates

Why Leifras Shares Are Trading Higher By Around 23%; Here Are 20 Stocks Moving Premarket
benzinga.com
Why Leifras Shares Are Trading Higher By Around 23%; Here Are 20 Stocks Moving Premarket

Leifras Co Ltd (NASDAQ: LFS) rose in pre-market trading after acquiring SWIFT JAPAN for JPY454.6 mil

12 Health Care Stocks Moving In Tuesday's After-Market Session
benzinga.com
12 Health Care Stocks Moving In Tuesday's After-Market Session

Gainers Quoin Pharmaceuticals (NASDAQ:QNRX) shares rose 40.3% to $4.56 during Tuesday's after-m

Why Sagtec Global Shares Are Trading Higher By Around 76%; Here Are 20 Stocks Moving Premarket
benzinga.com
Why Sagtec Global Shares Are Trading Higher By Around 76%; Here Are 20 Stocks Moving Premarket

SAGTEC GLOBAL (NASDAQ: SAGT) gained 75.6% in pre-market trading after projecting 35% revenue growth

Navitas Semiconductor, Abivax, MiniMed And Other Big Stocks Moving Higher On Wednesday
benzinga.com
Navitas Semiconductor, Abivax, MiniMed And Other Big Stocks Moving Higher On Wednesday

Dow falls 296 points. Navitas Semi rises on partnership with Nvidia. Other gainers: ABVX, MMED, KELY