Upstream Bio, Inc. UPB
Set alert
3.35 USD -0.06 -1.76%
At close · Nov 2
3.29 -0.06 -1.79%
After hours · Nov 2, 7:45 PM ET
3.16 Day range 3.46
2.68 52-week range 33.68
- YTD
- -87.66%
- 1 year
- -87.04%
- Open
- 3.42
- Prev close
- 3.41
- Mkt cap
- 183.48M
- Vol
- 936.31K
- Avg vol
- 856.44K
- EPS
- -2.83
- P/E
- 0.00
- Div yield
- 0.00%
More statistics
- Low
- 3.16
- High
- 3.46
- Forward P/E
- -2.45
- Beta
- 0.00
- Short ratio
- 2.45
- Inst. own
- 94.73%
- Dividend
- 0.00
- Ex-div date
- 50-d avg
- 18.55
- 200-d avg
- 19.11
- 1y target
- 47.86
Held by funds
68 US ETFs and mutual funds hold UPB · largest positions
Ownership
Held by insiders 14.86%
Held by institutions 94.73%
Float held by institutions 111.25%
Institutions 177
Top institutional holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| FMR, LLC | 13.91% | 7,518,202 | 65.18M | Dec 30, 2025 |
| Orbimed Advisors LLC. | 10.54% | 5,693,589 | 49.36M | Dec 30, 2025 |
| Blackrock Inc. | 6.19% | 3,344,504 | 29.00M | Dec 30, 2025 |
| Decheng Capital LLC | 5.82% | 3,143,078 | 27.25M | Dec 30, 2025 |
| NORGES BANK | 5.33% | 2,882,647 | 24.99M | Dec 30, 2025 |
| Enavate Sciences Gp, LLC | 4.55% | 2,459,703 | 21.33M | Dec 30, 2025 |
Top mutual fund holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 2.67% | 1,443,025 | 12.51M | Dec 30, 2025 |
| Fidelity Securities Fund-Fidelity Small Cap Growth Fund | 2.54% | 1,371,372 | 11.89M | Dec 30, 2025 |
| Fidelity Select Portfolios-Select Health Care Portfolio | 1.48% | 800,000 | 6.94M | Jan 30, 2026 |
| iShares Trust-iShares Russell 2000 ETF | 1.44% | 780,261 | 6.76M | Jan 30, 2026 |
| Fidelity Advisor Series VII-Fidelity Advisor Biotechnology Fund | 1.28% | 691,003 | 5.99M | Jan 30, 2026 |
| Fidelity Securities Fund-Fidelity Small Cap Growth K6 Fund | 1.26% | 682,018 | 5.91M | Dec 30, 2025 |
Insiders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| AI UPSTREAM LLC | Beneficial Owner of more than 10% of a Class of Security | Conversion of Exercise of derivative security | Oct 14, 2024 | 0 |
| AMBROSE ALLISON | General Counsel | Sale | Mar 15, 2026 | 16,525 |
| CHIMOVITS EREZ | Director and Beneficial Owner of more than 10% of a Class of Security | Conversion of Exercise of derivative security | Oct 14, 2024 | 0 |
| DEYKIN AARON M.D. | Officer | Sale | Mar 15, 2026 | 32,687 |
| GRAY MICHAEL P | Chief Operating Officer | Sale | Mar 15, 2026 | 29,648 |
| HOUGHTON ADAM | Officer | Sale | Mar 15, 2026 | 24,301 |