Upstream Bio, Inc. UPB

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3.23 USD +0.02 (+0.62%)

At closeNov 6, 2026, 4:00 PM EST

3.23 0.00 0.00%

After hours · Nov 6, 4:00 PM ET

3.02 Day range 3.28

2.68 52-week range 33.68

Held by insiders 14.86%

Held by institutions 94.73%

Float held by institutions 111.25%

Institutions 177

Top institutional holders
Holder	% held	Shares	Value	Reported
FMR, LLC	13.91%	7,518,202	65.18M	Dec 30, 2025
Orbimed Advisors LLC.	10.54%	5,693,589	49.36M	Dec 30, 2025
Blackrock Inc.	6.19%	3,344,504	29.00M	Dec 30, 2025
Decheng Capital LLC	5.82%	3,143,078	27.25M	Dec 30, 2025
NORGES BANK	5.33%	2,882,647	24.99M	Dec 30, 2025
Enavate Sciences Gp, LLC	4.55%	2,459,703	21.33M	Dec 30, 2025

Top mutual fund holders
Holder	% held	Shares	Value	Reported
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund	2.67%	1,443,025	12.51M	Dec 30, 2025
Fidelity Securities Fund-Fidelity Small Cap Growth Fund	2.54%	1,371,372	11.89M	Dec 30, 2025
Fidelity Select Portfolios-Select Health Care Portfolio	1.48%	800,000	6.94M	Jan 30, 2026
iShares Trust-iShares Russell 2000 ETF	1.44%	780,261	6.76M	Jan 30, 2026
Fidelity Advisor Series VII-Fidelity Advisor Biotechnology Fund	1.28%	691,003	5.99M	Jan 30, 2026
Fidelity Securities Fund-Fidelity Small Cap Growth K6 Fund	1.26%	682,018	5.91M	Dec 30, 2025

UPB insiders
Insider	Relation	Latest transaction	Date	Shares held
AI UPSTREAM LLC	Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security	Oct 14, 2024	0
AMBROSE ALLISON	General Counsel	Sale	Mar 15, 2026	16,525
CHIMOVITS EREZ	Director and Beneficial Owner of more than 10% of a Class of Security	Conversion of Exercise of derivative security	Oct 14, 2024	0
DEYKIN AARON M.D.	Officer	Sale	Mar 15, 2026	32,687
GRAY MICHAEL P	Chief Operating Officer	Sale	Mar 15, 2026	29,648
HOUGHTON ADAM	Officer	Sale	Mar 15, 2026	24,301

Ownership