Spyre Therapeutics, Inc. SYRE
104.48 USD -4.52 (-4.15%)
At closeNov 10, 2026, 4:00 PM EST
104.48 0.00 0.00%
After hours · Nov 10, 4:00 PM ET
103.19 Day range 109.15
21.63 52-week range 110.64
- YTD
- +218.93%
- 1 year
- +371.06%
Ownership
Held by insiders 1.54%
Held by institutions 105.50%
Float held by institutions 107.15%
Institutions 404
Top institutional holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| FMR, LLC | 13.72% | 13,026,187 | 1.36B | Jun 29, 2026 |
| Blackrock Inc. | 6.85% | 6,506,605 | 679.81M | Jun 29, 2026 |
| Perceptive Advisors Llc | 4.55% | 4,319,496 | 451.30M | Jun 29, 2026 |
| RTW Investments LP | 4.48% | 4,251,996 | 444.25M | Jun 29, 2026 |
| Paradigm Biocapital Advisors LP | 4.04% | 3,840,778 | 401.28M | Jun 29, 2026 |
| Vanguard Capital Management LLC | 3.63% | 3,448,681 | 360.32M | Jun 29, 2026 |
Top mutual fund holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| Fidelity Mt. Vernon Street Trust-Fidelity Growth Company Fund | 2.91% | 2,760,132 | 288.38M | Sep 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 2.61% | 2,482,298 | 259.35M | Jun 29, 2026 |
| SmallCap World Fund Inc | 2.37% | 2,247,758 | 234.85M | Sep 29, 2026 |
| iShares Trust-iShares Russell 2000 ETF | 2.09% | 1,982,310 | 207.11M | Sep 29, 2026 |
| SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF | 1.79% | 1,699,846 | 177.60M | Sep 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund | 0.94% | 896,559 | 93.67M | Jun 29, 2026 |
Insiders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| ALBERS JEFFREY W | Director | Sale | Aug 6, 2026 | 0 |
| BURROWS SCOTT L. | Chief Financial Officer | Sale | Sep 1, 2026 | 79,762 |
| FAIRMOUNT FUNDS MANAGEMENT LLC | Unknown | Sale | Jun 22, 2026 | 0 |
| HENDERSON MICHAEL THOMAS | Director | Sale | Jun 21, 2026 | 68,606 |
| KING-JONES HEIDY | Officer | Sale | Sep 1, 2026 | 2,845 |
| SLOAN SHELDON | Officer | Sale | Jun 30, 2026 | 0 |