Ionis Pharmaceuticals, Inc. IONS
Set alert
43.52 USD -0.87 -1.96%
At close
44.50 +0.98 +2.25%
Pre-market · Nov 2, 4:18 AM ET
43.27 Day range 45.12
42.08 52-week range 86.74
- YTD
- -44.99%
- 1 year
- -41.43%
- Open
- 44.69
- Prev close
- 44.39
- Mkt cap
- 7.23B
- Vol
- 1.52M
- Avg vol
- 3.14M
- EPS
- -3.48
- P/E
- 0.00
- Div yield
- 0.00%
More statistics
- Low
- 43.27
- High
- 45.12
- Forward P/E
- -37.97
- Beta
- 0.38
- Short ratio
- 5.20
- Inst. own
- 110.26%
- Dividend
- 0.00
- Ex-div date
- Earnings
- Nov 4, 2026
- 50-d avg
- 49.32
- 200-d avg
- 66.96
- 1y target
- 84.13
MAX chart
Events in this range
- Nov 4, 2026Earnings: —; estimate -1.22; surprise —%
Signals (172)
| Name | Date | Ago |
|---|---|---|
| SMA: Bearish | Sep 1, 2026 | 2 months ago |
| SMA: Bullish | Aug 1, 2026 | 3 months ago |
| SMA: Bearish | Jul 1, 2026 | 4 months ago |
| SMA: Bearish | Jul 1, 2026 | 4 months ago |
| MACD: Sell Signal | Jul 1, 2026 | 4 months ago |
| RSI: Overbought | Sep 1, 2025 | 1 year ago |
| SMA: Bullish | Jul 1, 2025 | 1 year ago |
| MACD: Buy Signal | Jul 1, 2025 | 1 year ago |
| SMA: Bullish | Jun 1, 2025 | 1 year ago |
| SMA: Bearish | Sep 1, 2024 | 2 years ago |
| SMA: Bearish | Sep 1, 2024 | 2 years ago |
| MACD: Sell Signal | Sep 1, 2024 | 2 years ago |
| SMA: Bullish | Jun 1, 2024 | 2 years ago |
| SMA: Bullish | Jun 1, 2024 | 2 years ago |
| MACD: Buy Signal | Jun 1, 2024 | 2 years ago |
| SMA: Bearish | May 1, 2024 | 2 years ago |
| MACD: Sell Signal | May 1, 2024 | 2 years ago |
| SMA: Bearish | Mar 1, 2024 | 2 years ago |
| SMA: Bullish | May 1, 2023 | 3 years ago |
| SMA: Bullish | May 1, 2023 | 3 years ago |
| SMA: Bearish | Feb 1, 2023 | 3 years ago |
| SMA: Bullish | Jan 1, 2023 | 3 years ago |
| SMA: Bearish | Dec 1, 2022 | 3 years ago |
| SMA: Bearish | Nov 1, 2022 | 4 years ago |
| SMA: Bullish | Sep 1, 2022 | 4 years ago |
| MACD: Buy Signal | May 1, 2022 | 4 years ago |
| SMA: Bullish | Mar 1, 2022 | 4 years ago |
| SMA: Bearish | Feb 1, 2021 | 5 years ago |
| SMA: Bearish | Feb 1, 2021 | 5 years ago |
| SMA: Bullish | Jan 1, 2021 | 5 years ago |
| SMA: Bullish | Dec 1, 2020 | 5 years ago |
| SMA: Bearish | Aug 1, 2020 | 6 years ago |
| SMA: Bearish | Aug 1, 2020 | 6 years ago |
| SMA: Bullish | Jun 1, 2020 | 6 years ago |
| SMA: Bullish | May 1, 2020 | 6 years ago |
| SMA: Bearish | Feb 1, 2020 | 6 years ago |
| MACD: Sell Signal | Oct 1, 2019 | 7 years ago |
| SMA: Bearish | Aug 1, 2019 | 7 years ago |
| MACD: Buy Signal | Nov 1, 2018 | 8 years ago |
| SMA: Bullish | Sep 1, 2018 | 8 years ago |
| SMA: Bullish | Jul 1, 2018 | 8 years ago |
| SMA: Bearish | Jun 1, 2018 | 8 years ago |
| SMA: Bullish | May 1, 2018 | 8 years ago |
| SMA: Bearish | Mar 1, 2018 | 8 years ago |
| SMA: Bearish | Mar 1, 2018 | 8 years ago |
| MACD: Sell Signal | Mar 1, 2018 | 8 years ago |
| SMA: Bullish | Jan 1, 2018 | 8 years ago |
| SMA: Bearish | Dec 1, 2017 | 8 years ago |
| SMA: Bullish | Jun 1, 2017 | 9 years ago |
| SMA: Bearish | May 1, 2017 | 9 years ago |
| SMA: Bullish | Apr 1, 2017 | 9 years ago |
| SMA: Bearish | Mar 1, 2017 | 9 years ago |
| SMA: Bullish | Feb 1, 2017 | 9 years ago |
| SMA: Bearish | Jan 1, 2017 | 9 years ago |
| MACD: Buy Signal | Jan 1, 2017 | 9 years ago |
| SMA: Bullish | Dec 1, 2016 | 9 years ago |
| SMA: Bullish | Nov 1, 2016 | 10 years ago |
| SMA: Bearish | Oct 1, 2016 | 10 years ago |
| SMA: Bullish | Sep 1, 2016 | 10 years ago |
| SMA: Bearish | Jan 1, 2016 | 10 years ago |
| SMA: Bearish | Jan 1, 2016 | 10 years ago |
| SMA: Bullish | Nov 1, 2015 | 11 years ago |
| SMA: Bullish | Oct 1, 2015 | 11 years ago |
| SMA: Bearish | Sep 1, 2015 | 11 years ago |
| MACD: Sell Signal | Jul 1, 2015 | 11 years ago |
| SMA: Bearish | Jun 1, 2015 | 11 years ago |
| RSI: Overbought | Dec 1, 2014 | 11 years ago |
| MACD: Buy Signal | Nov 1, 2014 | 12 years ago |
| SMA: Bullish | Aug 1, 2014 | 12 years ago |
| MACD: Sell Signal | May 1, 2014 | 12 years ago |
| SMA: Bearish | Apr 1, 2014 | 12 years ago |
| RSI: Overbought | Apr 1, 2013 | 13 years ago |
| SMA: Bullish | Jan 1, 2013 | 13 years ago |
| SMA: Bullish | Dec 1, 2012 | 13 years ago |
| SMA: Bearish | Oct 1, 2012 | 14 years ago |
| SMA: Bearish | Oct 1, 2012 | 14 years ago |
| SMA: Bullish | May 1, 2012 | 14 years ago |
| SMA: Bullish | Feb 1, 2012 | 14 years ago |
| MACD: Buy Signal | Jan 1, 2012 | 14 years ago |
| MACD: Sell Signal | Aug 1, 2011 | 15 years ago |
| SMA: Bearish | Jun 1, 2011 | 15 years ago |
| SMA: Bullish | Apr 1, 2011 | 15 years ago |
| MACD: Buy Signal | Apr 1, 2011 | 15 years ago |
| SMA: Bearish | Jan 1, 2011 | 15 years ago |
| SMA: Bullish | Nov 1, 2010 | 16 years ago |
| SMA: Bearish | Oct 1, 2009 | 17 years ago |
| SMA: Bearish | Sep 1, 2009 | 17 years ago |
| MACD: Sell Signal | Sep 1, 2009 | 17 years ago |
| MACD: Buy Signal | Jul 1, 2009 | 17 years ago |
| SMA: Bullish | Jun 1, 2009 | 17 years ago |
| SMA: Bearish | May 1, 2009 | 17 years ago |
| SMA: Bullish | Mar 1, 2009 | 17 years ago |
| SMA: Bullish | Mar 1, 2009 | 17 years ago |
| SMA: Bearish | Feb 1, 2009 | 17 years ago |
| SMA: Bullish | Dec 1, 2008 | 17 years ago |
| SMA: Bearish | Nov 1, 2008 | 18 years ago |
| SMA: Bearish | Oct 1, 2008 | 18 years ago |
| MACD: Sell Signal | Oct 1, 2008 | 18 years ago |
| MACD: Buy Signal | Aug 1, 2008 | 18 years ago |
| SMA: Bullish | Jul 1, 2008 | 18 years ago |
| MACD: Sell Signal | Apr 1, 2008 | 18 years ago |
| SMA: Bearish | Mar 1, 2008 | 18 years ago |
| RSI: Overbought | Sep 1, 2007 | 19 years ago |
| SMA: Bullish | Aug 1, 2006 | 20 years ago |
| SMA: Bearish | Jun 1, 2006 | 20 years ago |
| SMA: Bullish | Feb 1, 2006 | 20 years ago |
| SMA: Bullish | Jul 1, 2005 | 21 years ago |
| MACD: Buy Signal | Jul 1, 2005 | 21 years ago |
| MACD: Sell Signal | Mar 1, 2005 | 21 years ago |
| SMA: Bearish | Jan 1, 2005 | 21 years ago |
| SMA: Bullish | Dec 1, 2004 | 21 years ago |
| MACD: Buy Signal | Dec 1, 2004 | 21 years ago |
| MACD: Sell Signal | Nov 1, 2004 | 22 years ago |
| SMA: Bearish | May 1, 2004 | 22 years ago |
| MACD: Buy Signal | Oct 1, 2003 | 23 years ago |
| SMA: Bullish | Aug 1, 2003 | 23 years ago |
| SMA: Bearish | Apr 1, 2002 | 24 years ago |
| MACD: Sell Signal | Apr 1, 2002 | 24 years ago |
| SMA: Bearish | Feb 1, 2002 | 24 years ago |
| SMA: Bullish | May 1, 2001 | 25 years ago |
| MACD: Buy Signal | May 1, 2001 | 25 years ago |
| SMA: Bullish | Apr 1, 2001 | 25 years ago |
| MACD: Sell Signal | Mar 1, 2001 | 25 years ago |
| SMA: Bearish | Feb 1, 2001 | 25 years ago |
| SMA: Bearish | Feb 1, 2001 | 25 years ago |
| SMA: Bullish | Jan 1, 2001 | 25 years ago |
| SMA: Bullish | Jan 1, 2001 | 25 years ago |
| MACD: Buy Signal | Jan 1, 2001 | 25 years ago |
| MACD: Sell Signal | Nov 1, 2000 | 26 years ago |
| SMA: Bearish | Oct 1, 2000 | 26 years ago |
| SMA: Bearish | Oct 1, 2000 | 26 years ago |
| SMA: Bullish | Aug 1, 2000 | 26 years ago |
| SMA: Bullish | Aug 1, 2000 | 26 years ago |
| SMA: Bearish | Jul 1, 2000 | 26 years ago |
| SMA: Bearish | Jul 1, 2000 | 26 years ago |
| SMA: Bullish | Jun 1, 2000 | 26 years ago |
| SMA: Bullish | Jun 1, 2000 | 26 years ago |
| SMA: Bearish | Apr 1, 2000 | 26 years ago |
| SMA: Bearish | Apr 1, 2000 | 26 years ago |
| SMA: Bullish | Feb 1, 2000 | 26 years ago |
| SMA: Bullish | Feb 1, 2000 | 26 years ago |
| MACD: Buy Signal | Feb 1, 2000 | 26 years ago |
| SMA: Bearish | Dec 1, 1999 | 26 years ago |
| SMA: Bearish | Dec 1, 1999 | 26 years ago |
| MACD: Sell Signal | Dec 1, 1999 | 26 years ago |
| SMA: Bullish | Nov 1, 1999 | 27 years ago |
| MACD: Buy Signal | Oct 1, 1999 | 27 years ago |
| SMA: Bullish | Sep 1, 1999 | 27 years ago |
| SMA: Bearish | Mar 1, 1999 | 27 years ago |
| SMA: Bullish | Dec 1, 1998 | 27 years ago |
| SMA: Bearish | Apr 1, 1998 | 28 years ago |
| SMA: Bearish | Apr 1, 1998 | 28 years ago |
| SMA: Bullish | Mar 1, 1998 | 28 years ago |
| SMA: Bullish | Mar 1, 1998 | 28 years ago |
| SMA: Bearish | Dec 1, 1997 | 28 years ago |
| SMA: Bearish | Nov 1, 1997 | 29 years ago |
| SMA: Bullish | Sep 1, 1997 | 29 years ago |
| SMA: Bullish | Aug 1, 1997 | 29 years ago |
| SMA: Bearish | Jul 1, 1997 | 29 years ago |
| MACD: Sell Signal | Apr 1, 1997 | 29 years ago |
| SMA: Bearish | Mar 1, 1997 | 29 years ago |
| SMA: Bullish | Sep 1, 1996 | 30 years ago |
| SMA: Bearish | Aug 1, 1996 | 30 years ago |
| RSI: Overbought | Jun 1, 1996 | 30 years ago |
| SMA: Bullish | Apr 1, 1996 | 30 years ago |
| SMA: Bearish | Mar 1, 1996 | 30 years ago |
| SMA: Bullish | Mar 1, 1995 | 31 years ago |
| SMA: Bullish | Jan 1, 1995 | 31 years ago |
| SMA: Bearish | May 1, 1994 | 32 years ago |
| SMA: Bullish | Oct 1, 1993 | 33 years ago |
| SMA: Bearish | Jan 1, 1993 | 33 years ago |
| SMA: Bullish | Nov 1, 1992 | 34 years ago |
Ownership
Held by insiders 0.60%
Held by institutions 110.26%
Float held by institutions 110.92%
Institutions 703
Top institutional holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| FMR, LLC | 14.82% | 24,631,956 | 1.07B | Jun 29, 2026 |
| Capital World Investors | 13.04% | 21,669,226 | 943.04M | Jun 29, 2026 |
| Blackrock Inc. | 6.44% | 10,704,660 | 465.87M | Jun 29, 2026 |
| Vanguard Portfolio Management LLC | 4.73% | 7,859,529 | 342.05M | Jun 29, 2026 |
| Wellington Management Group, LLP | 4.60% | 7,651,415 | 332.99M | Jun 29, 2026 |
| Vanguard Capital Management LLC | 4.34% | 7,211,497 | 313.84M | Jun 29, 2026 |
Top mutual fund holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| Fidelity Mt. Vernon Street Trust-Fidelity Growth Company Fund | 5.12% | 8,503,655 | 370.08M | Aug 30, 2026 |
| Growth Fund of America | 4.61% | 7,668,655 | 333.74M | Sep 29, 2026 |
| VANGUARD SPECIALIZED FUNDS-Vanguard Health Care Fund | 3.74% | 6,212,640 | 270.37M | Jul 30, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 3.00% | 4,989,044 | 217.12M | Jun 29, 2026 |
| New Economy Fund | 2.93% | 4,868,802 | 211.89M | Sep 29, 2026 |
| SmallCap World Fund Inc | 2.68% | 4,458,145 | 194.02M | Sep 29, 2026 |
Insiders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| BAROLDI JOSEPH | Officer | Sale | Jun 25, 2026 | 0 |
| BENNETT C FRANK | Officer | Sale | Jul 6, 2026 | 0 |
| BERTHELSEN SPENCER R | Director | Conversion of Exercise of derivative security | Jul 14, 2026 | 161,303 |
| BIRCHLER BRIAN | Officer | Sale | Apr 15, 2026 | 67,500 |
| GEARY RICHARD S | Officer | Sale | Nov 5, 2025 | 59,657 |
| HAYDEN MICHAEL REUBEN | Director | Purchase | Jul 30, 2026 | 0 |
Held by funds
178 US ETFs and mutual funds hold IONS · largest positions