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Spyre Therapeutics, Inc. SYRE

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103.86 USD +7.27 (+7.53%)

At closeNov 6, 2026, 5:48 PM EST

103.00 -0.86 -0.83%

After hours · Nov 6, 5:48 PM ET

97.29 Day range 104.25
22.18 52-week range 108.92
YTD
+217.03%
1 year
+363.87%

Financial health

Altman Z-Score

118.07 Safe zone

Bankruptcy-risk model: below 1.81 distress, above 2.99 safe.

Piotroski F-Score

3 / 9 Weak

Nine pass/fail tests of profitability, leverage and efficiency.

Rating

D+1 / 5 overall

  • DCF 2
  • Return on Equity 1
  • Return on Assets 1
  • Debt / Equity 1
  • P/E 1
  • P/B 1

Valuation

P/E -16.5×
FY 2016: -2.0×FY 2017: -3.0×FY 2018: -3.5×FY 2019: -3.1×FY 2020: -5.2×FY 2021: -4.7×FY 2022: -0.5×FY 2023: -0.5×FY 2024: -7.3×FY 2025: -16.5×
FY 2016 5y median -4.7× FY 2025
P/S 0.0×
FY 2016: 9.2×FY 2017: 15.7×FY 2018: 40.1×FY 2019: 0.0×FY 2020: 0.0×FY 2021: 16.7×FY 2022: 16.3×FY 2023: 168×FY 2024: 0.0×FY 2025: 0.0×
FY 2016 5y median 16.3× FY 2025
P/B 2.9×
FY 2016: 0.7×FY 2017: 1.6×FY 2018: 2.3×FY 2019: 4.1×FY 2020: 3.0×FY 2021: 3.7×FY 2022: 0.8×FY 2023: 0.8×FY 2024: 2.1×FY 2025: 2.9×
FY 2016 5y median 2.1× FY 2025
P/FCF -12.4×
FY 2016: -2.2×FY 2017: -3.2×FY 2018: -4.8×FY 2019: -3.6×FY 2020: -5.2×FY 2021: -5.8×FY 2022: -0.5×FY 2023: -1.5×FY 2024: -7.0×FY 2025: -12.4×
FY 2016 5y median -5.8× FY 2025
EV/EBITDA -9.6×
FY 2016: 0.2×FY 2017: -2.5×FY 2018: -3.0×FY 2019: -3.0×FY 2020: -4.2×FY 2021: -4.7×FY 2022: -0.1×FY 2023: 0.3×FY 2024: -4.8×FY 2025: -9.6×
FY 2016 5y median -4.7× FY 2025
EV/Sales 0.0×
FY 2016: -1.1×FY 2017: 13.3×FY 2018: 34.3×FY 2019: 0.0×FY 2020: 0.0×FY 2021: 16.1×FY 2022: 3.3×FY 2023: -45.7×FY 2024: 0.0×FY 2025: 0.0×
FY 2016 5y median 0.0× FY 2025
FCF Yield -8.1%
FY 2016: -44.7%FY 2017: -30.8%FY 2018: -20.9%FY 2019: -27.5%FY 2020: -19.1%FY 2021: -17.4%FY 2022: -211.4%FY 2023: -67.3%FY 2024: -14.4%FY 2025: -8.1%
FY 2016 5y median -17.4% FY 2025

Profitability

Gross Margin 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 100.0%FY 2022: 100.0%FY 2023: 100.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 100.0% FY 2025
Operating Margin 0.0%
FY 2016: -473.3%FY 2017: -531.7%FY 2018: -1169.3%FY 2019: 0.0%FY 2020: 0.0%FY 2021: -350.3%FY 2022: -3640.2%FY 2023: -27348.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median -350.3% FY 2025
Net Margin 0.0%
FY 2016: -468.8%FY 2017: -523.3%FY 2018: -1140.6%FY 2019: 0.0%FY 2020: 0.0%FY 2021: -351.1%FY 2022: -3598.8%FY 2023: -38238.1%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median -351.1% FY 2025
ROE -21.7%
FY 2016: -34.5%FY 2017: -54.1%FY 2018: -65.8%FY 2019: -130.2%FY 2020: -57.9%FY 2021: -78.4%FY 2022: -166.6%FY 2023: -184.1%FY 2024: -40.2%FY 2025: -21.7%
FY 2016 5y median -78.4% FY 2025
ROIC -29.1%
FY 2016: -34.7%FY 2017: -54.9%FY 2018: -67.4%FY 2019: -123.3%FY 2020: -56.0%FY 2021: -72.8%FY 2022: -148.2%FY 2023: -78.2%FY 2024: -37.6%FY 2025: -29.1%
FY 2016 5y median -72.8% FY 2025
ROA -20.0%
FY 2016: -32.4%FY 2017: -48.6%FY 2018: -57.0%FY 2019: -94.1%FY 2020: -50.1%FY 2021: -59.9%FY 2022: -117.8%FY 2023: -99.1%FY 2024: -34.2%FY 2025: -20.0%
FY 2016 5y median -59.9% FY 2025

Growth (YoY)

Revenue 0.0%
FY 2016: -23.9%FY 2017: 12.5%FY 2018: -25.3%FY 2019: -100.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: -87.6%FY 2023: -62.0%FY 2024: -100.0%FY 2025: 0.0%
FY 2016 FY 2025
Operating Income -0.5%
FY 2016: -93.6%FY 2017: -26.3%FY 2018: -64.3%FY 2019: -76.7%FY 2020: -1.4%FY 2021: 19.4%FY 2022: -29.1%FY 2023: -185.8%FY 2024: 13.9%FY 2025: -0.5%
FY 2016 FY 2025
EPS (diluted) 37.7%
FY 2016: -124.2%FY 2017: 18.8%FY 2018: -18.3%FY 2019: -15.0%FY 2020: 38.1%FY 2021: 34.0%FY 2022: 0.6%FY 2023: -85.6%FY 2024: 93.1%FY 2025: 37.7%
FY 2016 FY 2025
Free Cash Flow -7.5%
FY 2016: -70.3%FY 2017: -32.4%FY 2018: -29.3%FY 2019: -106.0%FY 2020: -19.2%FY 2021: 32.2%FY 2022: -47.7%FY 2023: -24.6%FY 2024: -57.6%FY 2025: -7.5%
FY 2016 FY 2025

Financial Health

Current Ratio 13.3×
FY 2016: 16.8×FY 2017: 9.8×FY 2018: 7.5×FY 2019: 4.1×FY 2020: 9.1×FY 2021: 4.9×FY 2022: 4.2×FY 2023: 10.7×FY 2024: 11.3×FY 2025: 13.3×
FY 2016 5y median 10.7× FY 2025
Quick Ratio 13.3×
FY 2016: 16.8×FY 2017: 9.8×FY 2018: 7.5×FY 2019: 4.1×FY 2020: 9.1×FY 2021: 4.9×FY 2022: 4.2×FY 2023: 10.7×FY 2024: 11.3×FY 2025: 13.3×
FY 2016 5y median 10.7× FY 2025
Debt / Equity 0.0×
FY 2016: 0.0×FY 2017: 0.0×FY 2018: 0.0×FY 2019: 0.1×FY 2020: 0.0×FY 2021: 0.1×FY 2022: 0.1×FY 2023: 0.0×FY 2024: 0.0×FY 2025: 0.0×
FY 2016 5y median 0.0× FY 2025
Net Debt / EBITDA 0.4×
FY 2016: 2.2×FY 2017: 0.5×FY 2018: 0.5×FY 2019: 0.2×FY 2020: 1.1×FY 2021: 0.2×FY 2022: 0.4×FY 2023: 1.5×FY 2024: 0.4×FY 2025: 0.4×
FY 2016 5y median 0.4× FY 2025
Interest Coverage 0.0×
FY 2016: 0.0×FY 2017: 0.0×FY 2018: 0.0×FY 2019: 0.0×FY 2020: 0.0×FY 2021: 0.0×FY 2022: 0.0×FY 2023: 0.0×FY 2024: 0.0×FY 2025: 0.0×
FY 2016 5y median 0.0× FY 2025

Dividends

Dividend Yield 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025
Payout Ratio 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025

Annual · latest fiscal year ends 2025-12-31