Spyre Therapeutics, Inc. SYRE

Set alert

96.59 USD -2.45 (-2.47%)

At closeNov 6, 2026, 8:07 AM EST

92.53 -4.06 -4.20%

Pre-market · Nov 6, 8:07 AM ET

93.83 Day range 98.75

21.15 52-week range 110.18

Held by insiders 1.58%

Held by institutions 108.81%

Float held by institutions 110.56%

Institutions 396

Top institutional holders
Holder	% held	Shares	Value	Reported
FMR, LLC	12.78%	13,026,187	1.29B	Jun 29, 2026
Blackrock Inc.	6.38%	6,506,605	644.41M	Jun 29, 2026
Perceptive Advisors Llc	4.24%	4,319,496	427.80M	Jun 29, 2026
RTW Investments LP	4.17%	4,251,996	421.12M	Jun 29, 2026
Paradigm Biocapital Advisors LP	3.77%	3,840,778	380.39M	Jun 29, 2026
Vanguard Capital Management LLC	3.38%	3,448,681	341.56M	Jun 29, 2026

Top mutual fund holders
Holder	% held	Shares	Value	Reported
Fidelity Mt. Vernon Street Trust-Fidelity Growth Company Fund	2.71%	2,760,132	273.36M	Aug 30, 2026
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund	2.44%	2,482,298	245.85M	Jun 29, 2026
SmallCap World Fund Inc	2.21%	2,247,758	222.62M	Sep 29, 2026
iShares Trust-iShares Russell 2000 ETF	1.95%	1,982,310	196.33M	Sep 29, 2026
SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF	1.67%	1,699,846	168.35M	Sep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund	0.88%	896,559	88.80M	Jun 29, 2026

SYRE insiders
Insider	Relation	Latest transaction	Date	Shares held
ALBERS JEFFREY W	Director	Sale	Aug 6, 2026	0
BURROWS SCOTT L.	Chief Financial Officer	Sale	Sep 1, 2026	79,762
FAIRMOUNT FUNDS MANAGEMENT LLC	Unknown	Sale	Jun 22, 2026	0
HENDERSON MICHAEL THOMAS	Director	Sale	Jun 21, 2026	68,606
KING-JONES HEIDY	Officer	Sale	Sep 1, 2026	2,845
SLOAN SHELDON	Officer	Sale	Jun 30, 2026	0

Held by funds