Spyre Therapeutics, Inc. SYRE
103.86 USD +7.27 (+7.53%)
At closeNov 6, 2026, 5:48 PM EST
103.00 -0.86 -0.83%
After hours · Nov 6, 5:48 PM ET
97.29 Day range 104.25
22.18 52-week range 108.92
- YTD
- +217.03%
- 1 year
- +363.87%
Ownership
Held by insiders 1.54%
Held by institutions 105.35%
Float held by institutions 107.00%
Institutions 398
Top institutional holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| FMR, LLC | 13.72% | 13,026,187 | 1.35B | Jun 29, 2026 |
| Blackrock Inc. | 6.85% | 6,506,605 | 675.78M | Jun 29, 2026 |
| Perceptive Advisors Llc | 4.55% | 4,319,496 | 448.62M | Jun 29, 2026 |
| RTW Investments LP | 4.48% | 4,251,996 | 441.61M | Jun 29, 2026 |
| Paradigm Biocapital Advisors LP | 4.04% | 3,840,778 | 398.90M | Jun 29, 2026 |
| Vanguard Capital Management LLC | 3.63% | 3,448,681 | 358.18M | Jun 29, 2026 |
Top mutual fund holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| Fidelity Mt. Vernon Street Trust-Fidelity Growth Company Fund | 2.91% | 2,760,132 | 286.67M | Sep 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 2.61% | 2,482,298 | 257.81M | Jun 29, 2026 |
| SmallCap World Fund Inc | 2.37% | 2,247,758 | 233.45M | Sep 29, 2026 |
| iShares Trust-iShares Russell 2000 ETF | 2.09% | 1,982,310 | 205.88M | Sep 29, 2026 |
| SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF | 1.79% | 1,699,846 | 176.55M | Sep 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund | 0.94% | 896,559 | 93.12M | Jun 29, 2026 |
Insiders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| ALBERS JEFFREY W | Director | Sale | Aug 6, 2026 | 0 |
| BURROWS SCOTT L. | Chief Financial Officer | Sale | Sep 1, 2026 | 79,762 |
| FAIRMOUNT FUNDS MANAGEMENT LLC | Unknown | Sale | Jun 22, 2026 | 0 |
| HENDERSON MICHAEL THOMAS | Director | Sale | Jun 21, 2026 | 68,606 |
| KING-JONES HEIDY | Officer | Sale | Sep 1, 2026 | 2,845 |
| SLOAN SHELDON | Officer | Sale | Jun 30, 2026 | 0 |