Spyre Therapeutics, Inc. SYRE

Set alert

106.82 USD +2.34 (+2.24%)

At closeNov 11, 2026, 4:00 PM EST

106.82 0.00 0.00%

After hours · Nov 11, 4:00 PM ET

103.72 Day range 107.87

22.13 52-week range 110.64

Held by insiders 1.54%

Held by institutions 106.26%

Float held by institutions 107.92%

Institutions 409

Top institutional holders
Holder	% held	Shares	Value	Reported
FMR, LLC	14.21%	13,496,596	1.44B	Sep 29, 2026
Blackrock Inc.	6.85%	6,506,605	695.04M	Jun 29, 2026
Perceptive Advisors Llc	4.55%	4,319,496	461.41M	Jun 29, 2026
RTW Investments LP	4.48%	4,251,996	454.20M	Jun 29, 2026
Paradigm Biocapital Advisors LP	4.04%	3,840,778	410.27M	Jun 29, 2026
Vanguard Capital Management LLC	3.63%	3,448,681	368.39M	Jun 29, 2026

Top mutual fund holders
Holder	% held	Shares	Value	Reported
Fidelity Mt. Vernon Street Trust-Fidelity Growth Company Fund	2.91%	2,760,132	294.84M	Sep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund	2.61%	2,482,298	265.16M	Jun 29, 2026
SmallCap World Fund Inc	2.37%	2,247,758	240.11M	Sep 29, 2026
iShares Trust-iShares Russell 2000 ETF	2.09%	1,982,310	211.75M	Sep 29, 2026
SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF	1.79%	1,699,846	181.58M	Sep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund	0.94%	896,559	95.77M	Jun 29, 2026

SYRE insiders
Insider	Relation	Latest transaction	Date	Shares held
ALBERS JEFFREY W	Director	Sale	Aug 6, 2026	0
BURROWS SCOTT L.	Chief Financial Officer	Sale	Sep 1, 2026	79,762
FAIRMOUNT FUNDS MANAGEMENT LLC	Unknown	Sale	Jun 22, 2026	0
HENDERSON MICHAEL THOMAS	Director	Sale	Jun 21, 2026	68,606
KING-JONES HEIDY	Officer	Sale	Sep 1, 2026	2,845
SLOAN SHELDON	Officer	Sale	Jun 30, 2026	0

Held by funds