Rhythm Pharmaceuticals, Inc. RYTM

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110.68 USD +24.24 (+28.04%)

At closeNov 4, 2026, 7:42 PM EST

109.22 -1.46 -1.32%

After hours · Nov 4, 7:42 PM ET

85.04 Day range 110.68
74.50 52-week range 122.20
YTD
+3.40%
1 year
+5.42%
Market cap
7.67B
Revenue (ttm)
239.92M
Profit margin
-85.59%
EPS (ttm)
-2.91
Shares out
69.31M
Forward P/E
-170.06
YTD return
+3.40%
1-year return
+5.42%
Volume
5.49M
Avg volume
760.61K
Open
85.94
Previous close
86.44
Day's range
85.04 – 110.68
52-week range
74.50 – 122.20
Beta
2.13
Analysts
Strong Buy
Price target
140.29 (+26.8%)
Earnings date
Feb 25, 2027

2Y +54.43 (+96.76%)

5075100Jan 25Jun 25Nov 25Apr 26Aug 26110.68

Key statistics

Enterprise value
5.83B
PEG ratio
0.00
Price / sales
31.98
Price / book
53.49
Dividend yield
0.00%
Payout ratio
0.00%
Revenue growth
46.90%
Free cash flow
-130.59M
Total cash
330.90M
Total debt
109.78M
Return on equity
-117.05%
Short % of float
16.11%
50-day average
96.35
200-day average
96.95

Financials — quick view

All financials
RYTM Revenue — quarterly 71.25M
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026
RYTM Net income — quarterly -49.30M
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026
RYTM EPS — quarterly -0.73
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026

Earnings

RYTM recent earnings
Report dateQuarter endingEPS estimateEPS reportedSurpriseSurprise %
Feb 25, 2027Dec 30, 2026-0.63———
Nov 3, 2026Sep 30, 2026-0.70968-0.61+0.10+14.05%
Aug 4, 2026Jun 30, 2026-0.80721-0.73+0.08+9.57%
May 5, 2026Mar 31, 2026-0.86-0.83+0.03+3.49%
Feb 26, 2026Dec 31, 2025-0.79-0.73+0.06+7.59%
Nov 4, 2025Sep 30, 2025-0.72-0.82-0.10-13.89%

Upgrades / downgrades

RYTM analyst upgrades and downgrades
DateFirmActionFromTo
Nov 4, 2026CitizensmainMarket OutperformMarket Outperform
Nov 3, 2026NeedhammainBuyBuy
Oct 16, 2026William Blairinit—Outperform
Oct 15, 2026JP MorganmainOverweightOverweight
Oct 12, 2026HC Wainwright & Co.mainBuyBuy
Oct 8, 2026RBC CapitalmainOutperformOutperform

About Rhythm Pharmaceuticals, Inc.

Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases in the United States and internationally. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, Bardet-Biedl and Alström syndrome, Prader-Willi syndrome, and hypothalamic obesity. It is in Phase 3 clinical trials for treating acquired hypothalamic obesity, congenital hypothalamic obesity, pro-opiomelanocortin (POMC) and LEPR insufficiency obesities, SRC1 deficiency obesity, and SH2B1 deficiency obesity; and in phase 2 clinical trails for the treatment of Prader-Willi syndrome and MC4R deficiency. The company is also developing bivamelagon, an investigational oral small molecule MC4R agonist that is in phase 2 clinical trial for the treatment of MC4R pathway diseases; and RM-718, a next generation MC4R peptide agonist that is in phase 1 clinical trial for the treatment of hypothalamic obesity. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.

Sector
Healthcare
Industry
Biotechnology
Country
United States
Website
rhythmtx.com

News

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Insider holders

RYTM insider holders
InsiderRelationLatest transactionDateShares held
CRAMER PAMELA J.OfficerConversion of Exercise of derivative securityJan 29, 202629,376
GOOD JENNIFER LDirectorConversion of Exercise of derivative securityJun 22, 202611,712
JEAN CHRISTOPHE RDirectorConversion of Exercise of derivative securityJun 22, 202611,712
MATHERS EDWARD T.DirectorConversion of Exercise of derivative securityJun 17, 202512,771
MAZABRAUD YANNOfficerSaleAug 11, 202655,655
MCGIRR DAVID W JDirectorConversion of Exercise of derivative securityJun 22, 202611,712

Institution ownership

RYTM institution ownership
Holder% heldSharesValueReported
RA Capital Management, L.P.9.73%6,666,837737.89MJun 29, 2026
Blackrock Inc.8.98%6,156,902681.45MJun 29, 2026
Baker Bros. Advisors, LP8.18%5,604,483620.30MJun 29, 2026
Primecap Management Company4.62%3,168,853350.73MJun 29, 2026
Vanguard Portfolio Management LLC4.58%3,136,895347.19MJun 29, 2026
Vanguard Capital Management LLC4.39%3,005,977332.70MJun 29, 2026

Fund ownership

RYTM fund ownership
Holder% heldSharesValueReported
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund3.18%2,176,750240.92MJun 29, 2026
PRIMECAP Odyssey Funds-PRIMECAP Odyssey Aggressive Growth Fund2.82%1,935,739214.25MSep 29, 2026
SmallCap World Fund Inc2.58%1,769,519195.85MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund2.29%1,572,293174.02MJun 29, 2026
iShares Trust-iShares Russell 2000 ETF2.18%1,496,330165.61MSep 29, 2026
SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF1.73%1,184,359131.08MSep 29, 2026