Rhythm Pharmaceuticals, Inc. RYTM
At closeNov 4, 2026, 6:58 PM EST
After hours · Nov 4, 6:58 PM ET
- YTD
- +3.40%
- 1 year
- +5.42%
- Market cap
- 7.67B
- Revenue (ttm)
- 239.92M
- Profit margin
- -85.59%
- EPS (ttm)
- -2.91
- Shares out
- 69.31M
- Forward P/E
- -170.06
- YTD return
- +3.40%
- 1-year return
- +5.42%
- Volume
- 5.40M
- Avg volume
- 760.61K
- Open
- 85.94
- Previous close
- 86.44
- Day's range
- 85.04 – 110.68
- 52-week range
- 74.50 – 122.20
- Beta
- 2.13
- Analysts
- Strong Buy
- Price target
- 140.29 (+26.8%)
- Earnings date
- Feb 25, 2027
5D +17.16 (+18.35%)
Key statistics
- Enterprise value
- 5.83B
- PEG ratio
- 0.00
- Price / sales
- 31.98
- Price / book
- 53.49
- Dividend yield
- 0.00%
- Payout ratio
- 0.00%
- Revenue growth
- 46.90%
- Free cash flow
- -130.59M
- Total cash
- 330.90M
- Total debt
- 109.78M
- Return on equity
- -117.05%
- Short % of float
- 16.11%
- 50-day average
- 96.35
- 200-day average
- 96.95
Analyst view
Consensus: strong buy
- Target (low)
- 120.00
- Target (mean)
- 140.29
- Target (high)
- 160.00
- Strong buy5
- Buy12
- Hold2
- Sell0
- Strong sell0
Next earnings
Feb 25, 2027
Expected Feb 25, 2027. Consensus EPS estimate -0.72513.
Financials — quick view
Earnings
| Report date | Quarter ending | EPS estimate | EPS reported | Surprise | Surprise % |
|---|---|---|---|---|---|
| Feb 25, 2027 | Dec 30, 2026 | -0.63 | — | — | — |
| Nov 3, 2026 | Sep 30, 2026 | -0.70968 | -0.61 | +0.10 | +14.05% |
| Aug 4, 2026 | Jun 30, 2026 | -0.80721 | -0.73 | +0.08 | +9.57% |
| May 5, 2026 | Mar 31, 2026 | -0.86 | -0.83 | +0.03 | +3.49% |
| Feb 26, 2026 | Dec 31, 2025 | -0.79 | -0.73 | +0.06 | +7.59% |
| Nov 4, 2025 | Sep 30, 2025 | -0.72 | -0.82 | -0.10 | -13.89% |
Upgrades / downgrades
| Date | Firm | Action | From | To |
|---|---|---|---|---|
| Nov 4, 2026 | Citizens | main | Market Outperform | Market Outperform |
| Nov 3, 2026 | Needham | main | Buy | Buy |
| Oct 16, 2026 | William Blair | init | — | Outperform |
| Oct 15, 2026 | JP Morgan | main | Overweight | Overweight |
| Oct 12, 2026 | HC Wainwright & Co. | main | Buy | Buy |
| Oct 8, 2026 | RBC Capital | main | Outperform | Outperform |
About Rhythm Pharmaceuticals, Inc.
Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases in the United States and internationally. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, Bardet-Biedl and Alström syndrome, Prader-Willi syndrome, and hypothalamic obesity. It is in Phase 3 clinical trials for treating acquired hypothalamic obesity, congenital hypothalamic obesity, pro-opiomelanocortin (POMC) and LEPR insufficiency obesities, SRC1 deficiency obesity, and SH2B1 deficiency obesity; and in phase 2 clinical trails for the treatment of Prader-Willi syndrome and MC4R deficiency. The company is also developing bivamelagon, an investigational oral small molecule MC4R agonist that is in phase 2 clinical trial for the treatment of MC4R pathway diseases; and RM-718, a next generation MC4R peptide agonist that is in phase 1 clinical trial for the treatment of hypothalamic obesity. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.
- Sector
- Healthcare
- Industry
- Biotechnology
- Country
- United States
- Website
- rhythmtx.com
News
AstraZeneca Made $10 Billion Offer for Rhythm Pharmaceuticals Citizens Maintains Market Outperform on Rhythm Pharmaceuticals, Raises Price Target to $166
Rhythm Pharmaceuticals Receives Positive Guidance For IMCIVREE From National Institute For Health And Care Excellence To Add Adults With Bardet-Biedl Syndrome
Rhythm Pharmaceuticals Announces NICE Guidance for IMCIVREE® (Setmelanotide) Updated to Include Adults Living with Bardet-Biedl Syndrome
Rhythm Pharmaceuticals, Inc. (RYTM) Q3 2026 Earnings Call Transcript Needham Maintains Buy on Rhythm Pharmaceuticals, Lowers Price Target to $114
Rhythm Pharmaceuticals Q3 Earnings Call Highlights
Rhythm Pharmaceuticals Q3 2026 Earnings Call Transcript
Rhythm Pharmaceuticals, Inc. (RYTM) Reports Q3 Loss, Beats Revenue Estimates Rhythm Pharmaceuticals Q3 EPS $(0.61) Beats $(0.72) Estimate, Sales $92.128M Beat $84.349M Estimate
Your note
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Insider holders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| CRAMER PAMELA J. | Officer | Conversion of Exercise of derivative security | Jan 29, 2026 | 29,376 |
| GOOD JENNIFER L | Director | Conversion of Exercise of derivative security | Jun 22, 2026 | 11,712 |
| JEAN CHRISTOPHE R | Director | Conversion of Exercise of derivative security | Jun 22, 2026 | 11,712 |
| MATHERS EDWARD T. | Director | Conversion of Exercise of derivative security | Jun 17, 2025 | 12,771 |
| MAZABRAUD YANN | Officer | Sale | Aug 11, 2026 | 55,655 |
| MCGIRR DAVID W J | Director | Conversion of Exercise of derivative security | Jun 22, 2026 | 11,712 |
Institution ownership
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| RA Capital Management, L.P. | 9.73% | 6,666,837 | 737.89M | Jun 29, 2026 |
| Blackrock Inc. | 8.98% | 6,156,902 | 681.45M | Jun 29, 2026 |
| Baker Bros. Advisors, LP | 8.18% | 5,604,483 | 620.30M | Jun 29, 2026 |
| Primecap Management Company | 4.62% | 3,168,853 | 350.73M | Jun 29, 2026 |
| Vanguard Portfolio Management LLC | 4.58% | 3,136,895 | 347.19M | Jun 29, 2026 |
| Vanguard Capital Management LLC | 4.39% | 3,005,977 | 332.70M | Jun 29, 2026 |
Fund ownership
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 3.18% | 2,176,750 | 240.92M | Jun 29, 2026 |
| PRIMECAP Odyssey Funds-PRIMECAP Odyssey Aggressive Growth Fund | 2.82% | 1,935,739 | 214.25M | Sep 29, 2026 |
| SmallCap World Fund Inc | 2.58% | 1,769,519 | 195.85M | Sep 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund | 2.29% | 1,572,293 | 174.02M | Jun 29, 2026 |
| iShares Trust-iShares Russell 2000 ETF | 2.18% | 1,496,330 | 165.61M | Sep 29, 2026 |
| SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF | 1.73% | 1,184,359 | 131.08M | Sep 29, 2026 |
