Protagonist Therapeutics, Inc. PTGX

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139.04 USD -4.33 (-3.02%)

Nov 5, 2026, 10:46 AM EST

139.07 Day range 143.30
76.70 52-week range 160.81
YTD
+59.19%
1 year
+78.53%
Market cap
9.02B
Revenue (ttm)
281.99M
Profit margin
29.40%
EPS (ttm)
1.03
Shares out
64.71M
P/E ratio
135.30
Forward P/E
-1444.39
YTD return
+59.19%
1-year return
+78.53%
Volume
84.90K
Avg volume
651.62K
Open
142.56
Previous close
143.37
Day's range
139.07 – 143.30
52-week range
76.70 – 160.81
Beta
1.22
Analysts
Strong Buy
Price target
178.57 (+28.4%)
Earnings date
Nov 5, 2026

5Y +107.35 (+318.17%)

05010015020222023202420252026141.09

Key statistics

Enterprise value
8.30B
PEG ratio
0.00
Price / sales
32.90
Price / book
11.02
Dividend yield
0.00%
Payout ratio
0.00%
Revenue growth
3749.20%
Free cash flow
96.15M
Total cash
782.58M
Total debt
9.22M
Return on equity
10.98%
Short % of float
18.49%
50-day average
142.34
200-day average
117.19

Financials — quick view

All financials
PTGX Revenue — quarterly 213.47M
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026
PTGX Net income — quarterly 162.85M
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026
PTGX EPS — quarterly 2.47
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026

Earnings

PTGX recent earnings
Report dateQuarter endingEPS estimateEPS reportedSurpriseSurprise %
Nov 5, 2026Sep 30, 20262.50———
Aug 5, 2026Jun 30, 20262.232.29+0.06+2.69%
May 5, 2026Mar 31, 2026-0.650.05+0.70+107.69%
Feb 25, 2026Dec 31, 2025-0.53-0.69-0.16-30.19%
Nov 6, 2025Sep 30, 2025-0.59-0.62-0.03-5.08%
Aug 6, 2025Jun 30, 2025-0.53-0.55-0.02-3.77%

Upgrades / downgrades

PTGX analyst upgrades and downgrades
DateFirmActionFromTo
Oct 21, 2026TD CowenmainBuyBuy
Oct 12, 2026UBSinit—Buy
Sep 1, 2026BarclaysmainOverweightOverweight
Sep 1, 2026BMO CapitalmainOutperformOutperform
Aug 31, 2026CitigroupmainBuyBuy
Aug 31, 2026HC Wainwright & Co.mainBuyBuy

About Protagonist Therapeutics, Inc.

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

Sector
Healthcare
Industry
Biotechnology
Country
United States

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Insider holders

PTGX insider holders
InsiderRelationLatest transactionDateShares held
ALI ASIFChief Financial OfficerSaleApr 19, 202659,003
GIRAUDO BRYAN M.DirectorSaleMay 7, 20260
GUPTA SUNEELOfficerSaleNov 25, 2024267,433
MOLINA ARTURO MDOfficerSaleMar 25, 202684,115
O DOWD SARAH ADirectorStock Award(Grant)Jan 1, 20267,825
PATEL DINESH VChief Executive OfficerSaleSep 9, 2026522,968

Institution ownership

PTGX institution ownership
Holder% heldSharesValueReported
Blackrock Inc.15.93%10,307,8371.48BJun 29, 2026
Farallon Capital Management LLC9.81%6,348,906910.24MJun 29, 2026
RTW Investments LP7.82%5,061,175725.62MJun 29, 2026
Vanguard Portfolio Management LLC5.61%3,629,298520.33MJun 29, 2026
Wellington Management Group, LLP5.28%3,416,781489.86MJun 29, 2026
UBS Group AG5.25%3,399,221487.35MJun 29, 2026

Fund ownership

PTGX fund ownership
Holder% heldSharesValueReported
iShares Trust-iShares Core S&P Small-Cap ETF5.96%3,854,840552.67MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund3.16%2,044,938293.18MJun 29, 2026
iShares Trust-iShares Russell 2000 ETF2.46%1,594,175228.56MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund2.28%1,475,422211.53MJun 29, 2026
VANGUARD SPECIALIZED FUNDS-Vanguard Health Care Fund1.92%1,243,618178.30MJul 30, 2026
SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF1.57%1,013,552145.31MSep 29, 2026