Amylyx Pharmaceuticals, Inc. AMLX

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29.20 USD +1.16 (+4.14%)

At closeNov 3, 2026, 4:01 PM EST

29.20 0.00 0.00%

After hours · Nov 3, 4:01 PM ET

28.21 Day range 29.46
10.83 52-week range 41.14
YTD
+141.72%
1 year
+114.71%
Market cap
3.66B
EPS (ttm)
-1.41
Shares out
125.51M
Forward P/E
-26.78
YTD return
+141.72%
1-year return
+114.71%
Volume
1.20M
Avg volume
2.19M
Open
28.52
Previous close
28.04
Day's range
28.21 – 29.46
52-week range
10.83 – 41.14
Beta
-0.08
Analysts
Strong Buy
Price target
42.64 (+46.0%)
Earnings date
Nov 5, 2026

YTD +17.83 (+156.13%)

10203040Feb 3Apr 6Jun 4Aug 5Oct 529.25

Key statistics

Enterprise value
2.88B
PEG ratio
0.00
Price / sales
0.00
Price / book
13.59
Dividend yield
0.00%
Payout ratio
0.00%
Revenue growth
0.00%
Free cash flow
-77.32M
Total cash
250.76M
Total debt
5.25M
Return on equity
-74.73%
Short % of float
13.22%
50-day average
30.68
200-day average
20.15

Financials — quick view

All financials
AMLX Revenue — quarterly 0
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026
AMLX Net income — quarterly -43.42M
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026
AMLX EPS — quarterly -0.39
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026

Earnings

AMLX recent earnings
Report dateQuarter endingEPS estimateEPS reportedSurpriseSurprise %
Nov 5, 2026Sep 30, 2026-0.38099———
Aug 6, 2026Jun 30, 2026-0.3609-0.39-0.03-8.06%
May 7, 2026Mar 31, 2026-0.34-0.37-0.03-8.82%
Mar 3, 2026Dec 31, 2025-0.31-0.30+0.01+3.23%
Nov 6, 2025Sep 30, 2025-0.43-0.37+0.06+13.95%
Aug 7, 2025Jun 30, 2025-0.44-0.46-0.02-4.55%

Upgrades / downgrades

AMLX analyst upgrades and downgrades
DateFirmActionFromTo
Oct 15, 2026CitigroupmainBuyBuy
Aug 27, 2026GuggenheimmainBuyBuy
Aug 19, 2026MizuhomainOutperformOutperform
Aug 19, 2026GuggenheimmainBuyBuy
Aug 19, 2026BairdmainOutperformOutperform
Aug 18, 2026HC Wainwright & Co.mainBuyBuy

About Amylyx Pharmaceuticals, Inc.

Amylyx Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, engages in the discovery and development of treatment options for neurodegenerative diseases and endocrine conditions in the United States. It provides Avexitide, an investigational, first-in-class glucagon-like peptide-1, or GLP-1 receptor antagonist, which is in phase 3 clinical trial to treat post-bariatric hypoglycemia and congenital hyperinsulinism. The company also develops AMX0035, an oral, fixed-dose combination of sodium phenylbutyrate and taurursodiol which is phase 2 clinical trial for the treatment of wolfram syndrome, as well as in phase 2b/3 clinical trial to treat progressive supranuclear palsy; AMX0114, which is in phase 1 clinical trial for the treatment of amyotrophic lateral sclerosis; and long-acting GLP-1 receptor antagonist to treat post-bariatric hypoglycemia and other rare diseases. Further, it develops AMX0318, a GLP-1 receptor antagonist for the treatment of post-bariatric hypoglycemia and other rare diseaees. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.

Sector
Healthcare
Industry
Drug Manufacturers - Specialty & Generic
Country
United States
Website
amylyx.com

News

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Insider holders

AMLX insider holders
InsiderRelationLatest transactionDateShares held
BEDROSIAN CAMILLE LOfficerSaleSep 9, 2026278,064
COHEN JOSHUA BARRYChief Executive OfficerSaleSep 9, 20263,613,120
FIRESTONE KAREN M.DirectorConversion of Exercise of derivative securityAug 30, 2026116,900
FRATES JAMES MATTHEWChief Financial OfficerSaleSep 9, 2026400,156
KLEE JUSTIN BChief Executive OfficerSaleSep 9, 20263,613,060
MAZZARIELLO GINAOfficerSaleSep 9, 2026190,838

Institution ownership

AMLX institution ownership
Holder% heldSharesValueReported
FMR, LLC15.01%16,727,909488.45MJun 29, 2026
Blackrock Inc.7.92%8,827,085257.75MJun 29, 2026
Perceptive Advisors Llc7.48%8,334,882243.38MJun 29, 2026
TCG Crossover Management, LLC5.60%6,243,812182.32MJun 29, 2026
Commodore Capital Lp5.07%5,650,000164.98MJun 29, 2026
Jupiter Topco LLC4.70%5,236,102152.89MJun 29, 2026

Fund ownership

AMLX fund ownership
Holder% heldSharesValueReported
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund2.83%3,154,72392.12MJun 29, 2026
iShares Trust-iShares Russell 2000 ETF2.42%2,694,09378.67MSep 29, 2026
Fidelity Advisor Series VII-Fidelity Advisor Biotechnology Fund2.18%2,433,20071.05MAug 30, 2026
Fidelity Securities Fund-Fidelity Small Cap Growth Fund1.90%2,115,96161.79MJul 30, 2026
Fidelity Select Portfolios-Select Health Care Portfolio1.44%1,600,00046.72MAug 30, 2026
Fidelity Capital Trust-Fidelity Stock Selector Small Cap Fund1.33%1,476,80043.12MAug 30, 2026