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PTGX

Protagonist Therapeutics, Inc.

Healthcare · USD

Set alert

Price alert · PTGX

All alert types
144.85 USD +0.51 +0.35%
As of Oct 30, 2026 Extended hours 144.85 0.00%
Bid
144.84 × 2
Ask
144.91 × 2
142.54 Day range 146.00
75.95 52-week range 158.62
YTD
+65.85%
1 year
+86.06%
Open
144.34
Prev close
144.34
Mkt cap
9.37B
Vol
322.57K
Avg vol
648.58K
EPS
1.03
P/E
140.63
Div yield
0.00%
More statistics
Low
142.54
High
146.00
Forward P/E
-1459.30
Beta
1.52
Short ratio
12.29
Inst. own
119.68%
Dividend
0.00
Ex-div date
Earnings
Nov 5, 2026
50-d avg
143.05
200-d avg
116.32
1y target
178.57

5D chart

Chart tools
Interval
PTGX five-day price chart135.0137.9140.7143.6146.4Oct 23Oct 26Oct 27Oct 28Oct 29

Key statistics

Market cap
9.37B
Enterprise value
8.57B
Trailing P/E
140.63
Forward P/E
-1459.30
PEG ratio
0.00
Price / sales
33.24
Price / book
11.13
EPS (TTM)
1.03
Beta
1.52
Dividend yield
0.00%
Payout ratio
0.00%
Profit margin
29.40%
Revenue (TTM)
281.99M
Revenue growth
3749.20%
Free cash flow
96.15M
Total cash
782.58M
Total debt
9.22M
Return on equity
10.98%
Shares outstanding
64.71M
Short % of float
18.49%
50-day average
143.05
200-day average
116.32

Analyst view

Consensus: strong buy

Strong buy
Price target (mean) 178.57 +23.3% upside
Target (low)
149.00
Target (mean)
178.57
Target (high)
225.00
Ratings (0m) 14 14 buy · 0 hold · 0 sell
  • Strong buy3
  • Buy11
  • Hold0
  • Sell0
  • Strong sell0

Next earnings

Nov 5, 2026

Expected Nov 5, 2026. Consensus EPS estimate 2.66.

Earnings history

Financials — quick view

All financials
PTGX Revenue — quarterly 213.47M
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026
PTGX Net income — quarterly 162.85M
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026
PTGX EPS — quarterly 2.47
2022-Q3 20222022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 2026

Earnings

PTGX recent earnings
Report dateQuarter endingEPS estimateEPS reportedSurpriseSurprise %
Nov 5, 2026Sep 30, 20262.50———
Aug 5, 2026Jun 30, 20262.232.29+0.06+2.69%
May 5, 2026Mar 31, 2026-0.650.05+0.70+107.69%
Feb 25, 2026Dec 31, 2025-0.53-0.69-0.16-30.19%
Nov 6, 2025Sep 30, 2025-0.59-0.62-0.03-5.08%
Aug 6, 2025Jun 30, 2025-0.53-0.55-0.02-3.77%

Upgrades / downgrades

PTGX analyst upgrades and downgrades
DateFirmActionFromTo
Oct 21, 2026TD CowenmainBuyBuy
Oct 12, 2026UBSinit—Buy
Sep 1, 2026BarclaysmainOverweightOverweight
Sep 1, 2026BMO CapitalmainOutperformOutperform
Aug 31, 2026CitigroupmainBuyBuy
Aug 31, 2026HC Wainwright & Co.mainBuyBuy

About Protagonist Therapeutics, Inc.

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

Sector
Healthcare
Industry
Biotechnology
Country
United States

News

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Insider holders

PTGX insider holders
InsiderRelationLatest transactionDateShares held
ALI ASIFChief Financial OfficerSaleApr 19, 202659,003
GIRAUDO BRYAN M.DirectorSaleMay 7, 20260
GUPTA SUNEELOfficerConversion of Exercise of derivative securityNov 25, 2024267,433
MOLINA ARTURO MDOfficerConversion of Exercise of derivative securityMar 25, 202684,115
O DOWD SARAH ADirectorStock Award(Grant)Jan 1, 20267,825
PATEL DINESH VChief Executive OfficerConversion of Exercise of derivative securitySep 9, 2026522,968

Institution ownership

PTGX institution ownership
Holder% heldSharesValueReported
Blackrock Inc.15.93%10,307,8371.49BJun 29, 2026
Farallon Capital Management LLC9.81%6,348,906919.64MJun 29, 2026
RTW Investments LP7.82%5,061,175733.11MJun 29, 2026
Vanguard Portfolio Management LLC5.61%3,629,298525.70MJun 29, 2026
Wellington Management Group, LLP5.28%3,416,781494.92MJun 29, 2026
UBS Group AG5.25%3,399,221492.38MJun 29, 2026

Fund ownership

PTGX fund ownership
Holder% heldSharesValueReported
iShares Trust-iShares Core S&P Small-Cap ETF5.96%3,854,840558.37MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund3.16%2,044,938296.21MJun 29, 2026
iShares Trust-iShares Russell 2000 ETF2.46%1,594,175230.92MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund2.28%1,475,422213.71MJun 29, 2026
VANGUARD SPECIALIZED FUNDS-Vanguard Health Care Fund1.92%1,243,618180.14MJul 30, 2026
SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF1.57%1,013,552146.81MSep 29, 2026
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