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State Street SPDR S&P Biotech ETF XBI

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148.40 USD -10.70 (-6.73%)

At closeNov 5, 2026, 7:39 PM EST

147.29 -1.11 -0.75%

After hours · Nov 5, 7:39 PM ET

148.25 Day range 157.61

106.30 52-week range 169.89

YTD: +21.71%
1 year: +35.88%

Issuer: SPDR
Asset class: Equity
Expense ratio: 0.35%
Assets under management: $10.55B
NAV: 154.81
Holdings: 165
Inception: 2006-01-31
Top 10 weight: 18.05%

MRNA MODERNA INC 2.46%
EXEL EXELIXIS INC 1.81%
REGN REGENERON PHARMACEUTICALS 1.76%
HALO HALOZYME THERAPEUTICS INC 1.75%
UTHR UNITED THERAPEUTICS CORP 1.74%
BIIB BIOGEN INC 1.73%
AMGN AMGEN INC 1.72%
NTRA NATERA INC 1.72%
GILD GILEAD SCIENCES INC 1.68%
SYRE SPYRE THERAPEUTICS INC 1.67%
ABBV ABBVIE INC 1.67%
TWST TWIST BIOSCIENCE CORP 1.63%
TGTX TG THERAPEUTICS INC 1.63%
ORKA ORUKA THERAPEUTICS INC 1.59%
NBIX NEUROCRINE BIOSCIENCES INC 1.55%
VRTX VERTEX PHARMACEUTICALS INC 1.49%
PTCT PTC THERAPEUTICS INC 1.47%
ALKS ALKERMES PLC 1.47%
BBIO BRIDGEBIO PHARMA INC 1.42%
PTGX PROTAGONIST THERAPEUTICS INC 1.41%
RVMD REVOLUTION MEDICINES INC 1.37%
INCY INCYTE CORP 1.36%
GRAL GRAIL INC 1.35%
KYMR KYMERA THERAPEUTICS INC 1.35%
CRSP CRISPR THERAPEUTICS AG 1.34%

Healthcare 99.28%
Financial Services 0.72%

United States 96.79%
Switzerland 1.35%
United Kingdom 1.26%
Netherlands 0.48%
Ireland 0.07%
China 0.04%

Updated 2026-11-04

Funds holding XBI, by value held
Fund	Value held	Weight in fund
MKLOX	$25.24M	0.14%
BDYN	$11.66M	0.37%
EMPB	$5.62M	17.13%
TIH	$3.19M	0.49%
TSCV	$2.24M	1.22%
XNAV	$1.09M	3.77%
GEQ	$949.99K	0.46%
WLTG	$739.98K	0.98%
HFEQ	$302.04K	2.49%
HFND	$226.08K	0.62%
NSCS	$73.67K	0.85%
PSTR	$69.05K	0.10%
SECA	$52.50K	0.01%