Upstream Bio, Inc. UPB
Set alert
3.41 USD +0.14 +4.28%
At close · Oct 30
3.35 -0.06 -1.76%
After hours · Oct 30, 4:44 PM ET
3.15 Day range 3.43
2.74 52-week range 32.60
- YTD
- -87.44%
- 1 year
- -86.77%
- Open
- 3.26
- Prev close
- 3.27
- Mkt cap
- 186.77M
- Vol
- 946.13K
- Avg vol
- 846.31K
- EPS
- -2.88
- P/E
- 0.00
- Div yield
- 0.00%
More statistics
- Low
- 3.15
- High
- 3.43
- Forward P/E
- -2.45
- Beta
- 0.00
- Short ratio
- 2.45
- Inst. own
- 94.73%
- Dividend
- 0.00
- Ex-div date
- 50-d avg
- 18.55
- 200-d avg
- 19.11
- 1y target
- 47.86
2Y chart
Events in this range
- Nov 5, 2024Rating: JP Morgan · — → Overweight
- Oct 14, 2025Rating: Truist Securities · — → Buy
- Nov 18, 2025Rating: Evercore ISI Group · — → Outperform
- Dec 2, 2025Rating: LifeSci Capital · — → Outperform
- Dec 18, 2025Rating: Mizuho · — → Outperform
- Mar 27, 2026Downgrade: Evercore ISI Group · Outperform → In-Line
Signals (82)
| Name | Date | Ago |
|---|---|---|
| MACD: Buy Signal | Oct 28, 2026 | 3 days ago |
| RSI: Oversold | Oct 12, 2026 | 2 weeks ago |
| MACD: Sell Signal | Oct 5, 2026 | 3 weeks ago |
| RSI: Oversold | Oct 5, 2026 | 3 weeks ago |
| MACD: Buy Signal | Sep 30, 2026 | 1 month ago |
| SMA: Bearish | Aug 27, 2026 | 2 months ago |
| MACD: Sell Signal | Aug 27, 2026 | 2 months ago |
| SMA: Bullish | Aug 25, 2026 | 2 months ago |
| MACD: Buy Signal | Aug 25, 2026 | 2 months ago |
| SMA: Bearish | Aug 24, 2026 | 2 months ago |
| MACD: Sell Signal | Aug 24, 2026 | 2 months ago |
| SMA: Bullish | Aug 7, 2026 | 2 months ago |
| MACD: Buy Signal | Aug 5, 2026 | 2 months ago |
| MACD: Sell Signal | Jul 21, 2026 | 3 months ago |
| SMA: Bearish | Jul 10, 2026 | 3 months ago |
| SMA: Bullish | Jul 7, 2026 | 3 months ago |
| MACD: Buy Signal | Jun 23, 2026 | 4 months ago |
| RSI: Oversold | Jun 10, 2026 | 4 months ago |
| RSI: Oversold | Jun 8, 2026 | 4 months ago |
| RSI: Oversold | Jun 2, 2026 | 5 months ago |
| MACD: Sell Signal | May 18, 2026 | 5 months ago |
| SMA: Bearish | May 14, 2026 | 5 months ago |
| SMA: Bullish | May 13, 2026 | 5 months ago |
| MACD: Buy Signal | May 8, 2026 | 5 months ago |
| SMA: Bearish | May 7, 2026 | 5 months ago |
| MACD: Sell Signal | May 7, 2026 | 5 months ago |
| SMA: Bullish | Apr 22, 2026 | 6 months ago |
| MACD: Buy Signal | Mar 4, 2026 | 8 months ago |
| SMA: Bearish | Feb 11, 2026 | 8 months ago |
| RSI: Oversold | Feb 11, 2026 | 8 months ago |
| SMA: Bearish | Feb 5, 2026 | 8 months ago |
| MACD: Sell Signal | Jan 28, 2026 | 9 months ago |
| MACD: Buy Signal | Jan 27, 2026 | 9 months ago |
| MACD: Sell Signal | Jan 26, 2026 | 9 months ago |
| MACD: Buy Signal | Jan 12, 2026 | 9 months ago |
| SMA: Bullish | Jan 7, 2026 | 9 months ago |
| SMA: Bearish | Jan 5, 2026 | 9 months ago |
| MACD: Sell Signal | Dec 26, 2025 | 10 months ago |
| MACD: Buy Signal | Dec 22, 2025 | 10 months ago |
| MACD: Sell Signal | Dec 11, 2025 | 10 months ago |
| MACD: Buy Signal | Dec 8, 2025 | 10 months ago |
| MACD: Sell Signal | Dec 3, 2025 | 11 months ago |
| RSI: Overbought | Nov 28, 2025 | 11 months ago |
| MACD: Buy Signal | Nov 25, 2025 | 11 months ago |
| RSI: Overbought | Nov 25, 2025 | 11 months ago |
| MACD: Sell Signal | Nov 6, 2025 | 11 months ago |
| RSI: Overbought | Oct 30, 2025 | 1 year ago |
| RSI: Overbought | Oct 28, 2025 | 1 year ago |
| RSI: Overbought | Oct 20, 2025 | 1 year ago |
| RSI: Overbought | Oct 15, 2025 | 1 year ago |
| MACD: Buy Signal | Sep 30, 2025 | 1 year ago |
| SMA: Bullish | Sep 26, 2025 | 1 year ago |
| SMA: Bearish | Sep 25, 2025 | 1 year ago |
| MACD: Sell Signal | Sep 9, 2025 | 1 year ago |
| MACD: Buy Signal | Sep 3, 2025 | 1 year ago |
| RSI: Overbought | Sep 2, 2025 | 1 year ago |
| MACD: Sell Signal | Aug 20, 2025 | 1 year ago |
| MACD: Buy Signal | Jul 24, 2025 | 1 year ago |
| RSI: Overbought | Jul 24, 2025 | 1 year ago |
| MACD: Sell Signal | Jul 15, 2025 | 1 year ago |
| MACD: Buy Signal | Jul 14, 2025 | 1 year ago |
| MACD: Sell Signal | Jul 11, 2025 | 1 year ago |
| MACD: Buy Signal | Jul 10, 2025 | 1 year ago |
| MACD: Sell Signal | Jun 17, 2025 | 1 year ago |
| RSI: Overbought | Jun 6, 2025 | 1 year ago |
| MACD: Buy Signal | May 22, 2025 | 1 year ago |
| MACD: Sell Signal | May 13, 2025 | 1 year ago |
| MACD: Buy Signal | May 12, 2025 | 1 year ago |
| MACD: Sell Signal | May 6, 2025 | 1 year ago |
| RSI: Overbought | Apr 22, 2025 | 1 year ago |
| SMA: Bullish | Apr 15, 2025 | 1 year ago |
| MACD: Buy Signal | Apr 11, 2025 | 1 year ago |
| MACD: Sell Signal | Mar 25, 2025 | 1 year ago |
| MACD: Buy Signal | Feb 12, 2025 | 1 year ago |
| MACD: Sell Signal | Feb 11, 2025 | 1 year ago |
| RSI: Oversold | Feb 4, 2025 | 1 year ago |
| MACD: Buy Signal | Jan 29, 2025 | 1 year ago |
| RSI: Oversold | Jan 16, 2025 | 1 year ago |
| RSI: Oversold | Jan 13, 2025 | 1 year ago |
| MACD: Sell Signal | Jan 10, 2025 | 1 year ago |
| MACD: Buy Signal | Dec 23, 2024 | 1 year ago |
| MACD: Sell Signal | Dec 19, 2024 | 1 year ago |
Key statistics
- Market cap
- 468.51M
- Enterprise value
- 0
- Trailing P/E
- 0.00
- Forward P/E
- -2.45
- PEG ratio
- 0.00
- Price / sales
- 164.16
- Price / book
- 1.38
- EPS (TTM)
- -2.65
- Beta
- 0.00
- Dividend yield
- 0.00%
- Payout ratio
- 0.00%
- Profit margin
- 0.00%
- Revenue (TTM)
- 2.85M
- Revenue growth
- 9.00%
- Free cash flow
- 0
- Total cash
- 341.51M
- Total debt
- 1.27M
- Return on equity
- -35.44%
- Shares outstanding
- 54.04M
- Short % of float
- 15.85%
- 50-day average
- 18.55
- 200-day average
- 19.11
Analyst view
Consensus: strong buy
Strong buy
Price target (mean) 47.86 +1303.4% upside
Now 3.41
- Target (low)
- 35.00
- Target (mean)
- 47.86
- Target (high)
- 75.00
Ratings (0m) 8 8 buy · 0 hold · 0 sell
- Strong buy2
- Buy6
- Hold0
- Sell0
- Strong sell0
Next earnings
Consensus EPS estimate -0.76667.
Financials — quick view
UPB Revenue — quarterly 773.00K
UPB Net income — quarterly -39.70M
UPB EPS — quarterly -0.73
Upgrades / downgrades
| Date | Firm | Action | From | To |
|---|---|---|---|---|
| Mar 27, 2026 | Evercore ISI Group | down | Outperform | In-Line |
| Dec 18, 2025 | Mizuho | init | — | Outperform |
| Dec 2, 2025 | LifeSci Capital | init | — | Outperform |
| Nov 18, 2025 | Evercore ISI Group | init | — | Outperform |
| Oct 14, 2025 | Truist Securities | init | — | Buy |
| Nov 5, 2024 | JP Morgan | init | — | Overweight |
About Upstream Bio, Inc.
Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 clinical development for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps, and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.
- Sector
- Healthcare
- Industry
- Biotechnology
- Country
- United States
- Website
- upstreambio.com
News
No recent headlines
Headlines appear here as they are published.
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Insider holders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| AI UPSTREAM LLC | Beneficial Owner of more than 10% of a Class of Security | Conversion of Exercise of derivative security | Oct 14, 2024 | 0 |
| AMBROSE ALLISON | General Counsel | Sale | Mar 15, 2026 | 16,525 |
| CHIMOVITS EREZ | Director and Beneficial Owner of more than 10% of a Class of Security | Conversion of Exercise of derivative security | Oct 14, 2024 | 0 |
| DEYKIN AARON M.D. | Officer | Sale | Mar 15, 2026 | 32,687 |
| GRAY MICHAEL P | Chief Operating Officer | Sale | Mar 15, 2026 | 29,648 |
| HOUGHTON ADAM | Officer | Sale | Mar 15, 2026 | 24,301 |
Institution ownership
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| FMR, LLC | 13.91% | 7,518,202 | 65.18M | Dec 30, 2025 |
| Orbimed Advisors LLC. | 10.54% | 5,693,589 | 49.36M | Dec 30, 2025 |
| Blackrock Inc. | 6.19% | 3,344,504 | 29.00M | Dec 30, 2025 |
| Decheng Capital LLC | 5.82% | 3,143,078 | 27.25M | Dec 30, 2025 |
| NORGES BANK | 5.33% | 2,882,647 | 24.99M | Dec 30, 2025 |
| Enavate Sciences Gp, LLC | 4.55% | 2,459,703 | 21.33M | Dec 30, 2025 |
Fund ownership
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 2.67% | 1,443,025 | 12.51M | Dec 30, 2025 |
| Fidelity Securities Fund-Fidelity Small Cap Growth Fund | 2.54% | 1,371,372 | 11.89M | Dec 30, 2025 |
| Fidelity Select Portfolios-Select Health Care Portfolio | 1.48% | 800,000 | 6.94M | Jan 30, 2026 |
| iShares Trust-iShares Russell 2000 ETF | 1.44% | 780,261 | 6.76M | Jan 30, 2026 |
| Fidelity Advisor Series VII-Fidelity Advisor Biotechnology Fund | 1.28% | 691,003 | 5.99M | Jan 30, 2026 |
| Fidelity Securities Fund-Fidelity Small Cap Growth K6 Fund | 1.26% | 682,018 | 5.91M | Dec 30, 2025 |