Spyre Therapeutics, Inc. SYRE
104.44 USD -2.38 (-2.23%)
Nov 12, 2026, 11:10 AM EST
101.40 Day range 105.28
22.13 52-week range 110.64
- YTD
- +218.80%
- 1 year
- +345.75%
Held by funds
143 US ETFs and mutual funds hold SYRE · largest positions
Ownership
Held by insiders 1.54%
Held by institutions 106.26%
Float held by institutions 107.92%
Institutions 409
Top institutional holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| FMR, LLC | 14.21% | 13,496,596 | 1.44B | Sep 29, 2026 |
| Blackrock Inc. | 6.85% | 6,506,605 | 695.04M | Jun 29, 2026 |
| Perceptive Advisors Llc | 4.55% | 4,319,496 | 461.41M | Jun 29, 2026 |
| RTW Investments LP | 4.48% | 4,251,996 | 454.20M | Jun 29, 2026 |
| Paradigm Biocapital Advisors LP | 4.04% | 3,840,778 | 410.27M | Jun 29, 2026 |
| Vanguard Capital Management LLC | 3.63% | 3,448,681 | 368.39M | Jun 29, 2026 |
Top mutual fund holders
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| Fidelity Mt. Vernon Street Trust-Fidelity Growth Company Fund | 2.91% | 2,760,132 | 294.84M | Sep 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 2.61% | 2,482,298 | 265.16M | Jun 29, 2026 |
| SmallCap World Fund Inc | 2.37% | 2,247,758 | 240.11M | Sep 29, 2026 |
| iShares Trust-iShares Russell 2000 ETF | 2.09% | 1,982,310 | 211.75M | Sep 29, 2026 |
| SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF | 1.79% | 1,699,846 | 181.58M | Sep 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund | 0.94% | 896,559 | 95.77M | Jun 29, 2026 |
Insiders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| ALBERS JEFFREY W | Director | Sale | Aug 6, 2026 | 0 |
| BURROWS SCOTT L. | Chief Financial Officer | Sale | Sep 1, 2026 | 79,762 |
| FAIRMOUNT FUNDS MANAGEMENT LLC | Unknown | Sale | Jun 22, 2026 | 0 |
| HENDERSON MICHAEL THOMAS | Director | Sale | Jun 21, 2026 | 68,606 |
| KING-JONES HEIDY | Officer | Sale | Sep 1, 2026 | 2,845 |
| SLOAN SHELDON | Officer | Sale | Jun 30, 2026 | 0 |