Spyre Therapeutics, Inc. SYRE
103.89 USD +7.30 (+7.56%)
Nov 6, 2026, 3:33 PM EST
97.29 Day range 103.89
21.15 52-week range 110.18
- YTD
- +217.12%
- 1 year
- +364.00%
Analyst view
Consensus: strong buy
Strong buy
Price target (mean) 122.53 +17.9% upside
Now 103.89
- Target (low)
- 110.00
- Target (mean)
- 122.53
- Target (high)
- 131.00
Ratings (0m) 18 17 buy · 1 hold · 0 sell
- Strong buy1
- Buy16
- Hold1
- Sell0
- Strong sell0
Recommendation trend
- This month 18
- 1 month ago 18
- 2 months ago 16
- 3 months ago 17
Earnings and revenue estimates
Consensus for the coming quarters and fiscal years
| Period | EPS estimate | Low – high | Year ago | EPS growth | Revenue estimate | Revenue growth | Analysts |
|---|---|---|---|---|---|---|---|
| Current quarter | -0.86883 | -1.42 – -0.69 | -0.74 | -17.4% | 0 | 0.0% | 13 |
| Next quarter | -0.84077 | -1.00 – -0.67309 | -0.74 | -13.6% | 0 | 0.0% | 4 |
| Current year | -2.82 | -3.75 – -2.37 | -1.98 | -42.6% | 0 | 0.0% | 13 |
| Next year | -3.59 | -4.51 – -2.36 | -2.82 | -27.1% | 0 | 0.0% | 13 |
Upgrades and downgrades
The latest rating changes
| Date | Firm | Action | From | To |
|---|---|---|---|---|
| Nov 4, 2026 | Guggenheim | Maintained | Buy | Buy |
| Nov 4, 2026 | Wedbush | Maintained | Outperform | Outperform |
| Oct 19, 2026 | BTIG | Reiterated | Buy | Buy |
| Oct 12, 2026 | UBS | Initiated | — | Buy |
| Oct 1, 2026 | JP Morgan | Initiated | — | Overweight |
| Oct 1, 2026 | BTIG | Reiterated | Buy | Buy |
| Sep 9, 2026 | Wedbush | Reiterated | Outperform | Outperform |
| Sep 8, 2026 | BTIG | Reiterated | Buy | Buy |
| Aug 26, 2026 | Deutsche Bank | Maintained | Buy | Buy |
| Aug 26, 2026 | Wedbush | Maintained | Outperform | Outperform |
| Aug 26, 2026 | BTIG | Maintained | Buy | Buy |
| Aug 11, 2026 | BTIG | Maintained | Buy | Buy |
| Aug 5, 2026 | Wells Fargo | Maintained | Overweight | Overweight |
| Aug 5, 2026 | Guggenheim | Maintained | Buy | Buy |
| Aug 5, 2026 | Wedbush | Maintained | Outperform | Outperform |
| Jul 28, 2026 | Wolfe Research | Downgrade | Outperform | Peer Perform |
| Jul 13, 2026 | Mizuho | Maintained | Outperform | Outperform |
| Jun 23, 2026 | Deutsche Bank | Maintained | Buy | Buy |
| Jun 15, 2026 | BTIG | Maintained | Buy | Buy |
| Jun 4, 2026 | Deutsche Bank | Maintained | Buy | Buy |
| May 6, 2026 | Citigroup | Maintained | Buy | Buy |
| May 6, 2026 | Stifel | Maintained | Buy | Buy |
| Apr 17, 2026 | Jones Trading | Maintained | Buy | Buy |
| Apr 14, 2026 | Wells Fargo | Maintained | Overweight | Overweight |
| Apr 14, 2026 | Wedbush | Maintained | Outperform | Outperform |
| Apr 14, 2026 | Baird | Maintained | Outperform | Outperform |
| Apr 14, 2026 | Raymond James | Initiated | — | Strong Buy |
| Apr 14, 2026 | Deutsche Bank | Maintained | Buy | Buy |
| Apr 13, 2026 | Leerink Partners | Maintained | Outperform | Outperform |
| Apr 13, 2026 | Jefferies | Maintained | Buy | Buy |