Menu

Protagonist Therapeutics, Inc. PTGX

Full chart Compare
Set alert

Price alert · PTGX

All alert types
134.02 USD -2.25 (-1.65%)

Nov 11, 2026, 2:35 PM EST

132.03 Day range 136.98
77.00 52-week range 160.81
YTD
+53.44%
1 year
+56.63%
Market cap
8.75B
Revenue (ttm)
551.69M
Profit margin
62.04%
EPS (ttm)
4.73
Shares out
65.27M
P/E ratio
28.33
Forward P/E
226.84
YTD return
+53.44%
1-year return
+56.63%
Volume
179.77K
Avg volume
662.25K
Open
136.51
Previous close
136.26
Day's range
132.03 – 136.98
52-week range
77.00 – 160.81
Beta
1.22
Analysts
Strong Buy
Price target
182.36 (+36.1%)
Earnings date
Feb 24, 2027

5D -7.55 (-5.25%)

130135140145WedThuFriMonTue136.26

Key statistics

Enterprise value
8.08B
PEG ratio
0.00
Price / sales
16.12
Price / book
8.19
Dividend yield
0.00%
Payout ratio
0.00%
Revenue growth
5723.60%
Free cash flow
-24.01M
Total cash
800.06M
Total debt
8.63M
Return on equity
39.56%
Short % of float
18.33%
50-day average
141.35
200-day average
118.24

Financials — quick view

All financials
PTGX Revenue — quarterly 274.41M
2022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 20262026-Q3 2026
PTGX Net income — quarterly 220.01M
2022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 20262026-Q3 2026
PTGX EPS — quarterly 3.32
2022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 20262026-Q3 2026

Earnings

PTGX recent earnings
Report dateQuarter endingEPS estimateEPS reportedSurpriseSurprise %
Feb 24, 2027Dec 30, 2026-0.38———
Nov 5, 2026Sep 30, 20263.063.07+0.01+0.33%
Aug 5, 2026Jun 30, 20262.232.29+0.06+2.69%
May 5, 2026Mar 31, 2026-0.650.05+0.70+107.69%
Feb 25, 2026Dec 31, 2025-0.53-0.69-0.16-30.19%
Nov 6, 2025Sep 30, 2025-0.59-0.62-0.03-5.08%

Upgrades / downgrades

PTGX analyst upgrades and downgrades
DateFirmActionFromTo
Nov 6, 2026HC Wainwright & Co.mainBuyBuy
Oct 21, 2026TD CowenmainBuyBuy
Oct 12, 2026UBSinit—Buy
Sep 1, 2026BarclaysmainOverweightOverweight
Sep 1, 2026BMO CapitalmainOutperformOutperform
Aug 31, 2026CitigroupmainBuyBuy

About Protagonist Therapeutics, Inc.

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

Sector
Healthcare
Industry
Biotechnology
Country
United States

News

Your note

Sign in to keep a note on PTGX — it syncs with the Stock Master app.

Insider holders

PTGX insider holders
InsiderRelationLatest transactionDateShares held
ALI ASIFChief Financial OfficerSaleApr 19, 202659,003
GIRAUDO BRYAN M.DirectorSaleMay 7, 20260
GUPTA SUNEELOfficerSaleNov 25, 2024267,433
MOLINA ARTURO MDOfficerSaleMar 25, 202684,115
O DOWD SARAH ADirectorStock Award(Grant)Jan 1, 20267,825
PATEL DINESH VChief Executive OfficerSaleSep 9, 2026522,968

Institution ownership

PTGX institution ownership
Holder% heldSharesValueReported
Blackrock Inc.15.79%10,307,8371.40BJun 29, 2026
Farallon Capital Management LLC9.73%6,348,906865.10MJun 29, 2026
RTW Investments LP7.75%5,061,175689.64MJun 29, 2026
Vanguard Portfolio Management LLC5.56%3,629,298494.53MJun 29, 2026
Wellington Management Group, LLP5.23%3,416,781465.57MJun 29, 2026
UBS Group AG5.21%3,399,221463.18MJun 29, 2026

Fund ownership

PTGX fund ownership
Holder% heldSharesValueReported
iShares Trust-iShares Core S&P Small-Cap ETF5.91%3,854,840525.26MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund3.13%2,044,938278.64MJun 29, 2026
iShares Trust-iShares Russell 2000 ETF2.44%1,594,175217.22MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund2.26%1,475,422201.04MJun 29, 2026
VANGUARD SPECIALIZED FUNDS-Vanguard Health Care Fund1.91%1,243,618169.46MJul 30, 2026
SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF1.55%1,013,552138.11MSep 29, 2026