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Protagonist Therapeutics, Inc. PTGX

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135.00 USD -0.90 (-0.66%)

Nov 10, 2026, 1:24 PM EST

133.41 Day range 137.97
77.00 52-week range 160.81
YTD
+54.57%
1 year
+62.20%
Market cap
8.81B
Revenue (ttm)
551.69M
Profit margin
62.04%
EPS (ttm)
4.73
Shares out
65.27M
P/E ratio
28.53
Forward P/E
260.67
YTD return
+54.57%
1-year return
+62.20%
Volume
129.65K
Avg volume
658.78K
Open
134.21
Previous close
135.90
Day's range
133.41 – 137.97
52-week range
77.00 – 160.81
Beta
1.22
Analysts
Strong Buy
Price target
182.36 (+35.1%)
Earnings date
Feb 24, 2027

5D -8.77 (-6.10%)

130135140145WedThuFriMonTue135.04

Key statistics

Enterprise value
7.83B
PEG ratio
0.00
Price / sales
16.08
Price / book
8.17
Dividend yield
0.00%
Payout ratio
0.00%
Revenue growth
5723.60%
Free cash flow
-24.01M
Total cash
800.06M
Total debt
8.63M
Return on equity
39.56%
Short % of float
18.49%
50-day average
141.52
200-day average
117.98

Financials — quick view

All financials
PTGX Revenue — quarterly 274.41M
2022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 20262026-Q3 2026
PTGX Net income — quarterly 220.01M
2022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 20262026-Q3 2026
PTGX EPS — quarterly 3.32
2022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 20262026-Q3 2026

Earnings

PTGX recent earnings
Report dateQuarter endingEPS estimateEPS reportedSurpriseSurprise %
Feb 24, 2027Dec 30, 2026-0.3206———
Nov 5, 2026Sep 30, 20262.503.07+0.57+22.80%
Aug 5, 2026Jun 30, 20262.232.29+0.06+2.69%
May 5, 2026Mar 31, 2026-0.650.05+0.70+107.69%
Feb 25, 2026Dec 31, 2025-0.53-0.69-0.16-30.19%
Nov 6, 2025Sep 30, 2025-0.59-0.62-0.03-5.08%

Upgrades / downgrades

PTGX analyst upgrades and downgrades
DateFirmActionFromTo
Nov 6, 2026HC Wainwright & Co.mainBuyBuy
Oct 21, 2026TD CowenmainBuyBuy
Oct 12, 2026UBSinit—Buy
Sep 1, 2026BarclaysmainOverweightOverweight
Sep 1, 2026BMO CapitalmainOutperformOutperform
Aug 31, 2026CitigroupmainBuyBuy

About Protagonist Therapeutics, Inc.

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

Sector
Healthcare
Industry
Biotechnology
Country
United States

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Insider holders

PTGX insider holders
InsiderRelationLatest transactionDateShares held
ALI ASIFChief Financial OfficerSaleApr 19, 202659,003
GIRAUDO BRYAN M.DirectorSaleMay 7, 20260
GUPTA SUNEELOfficerConversion of Exercise of derivative securityNov 25, 2024267,433
MOLINA ARTURO MDOfficerConversion of Exercise of derivative securityMar 25, 202684,115
O DOWD SARAH ADirectorStock Award(Grant)Jan 1, 20267,825
PATEL DINESH VChief Executive OfficerConversion of Exercise of derivative securitySep 9, 2026522,968

Institution ownership

PTGX institution ownership
Holder% heldSharesValueReported
Blackrock Inc.15.93%10,307,8371.40BJun 29, 2026
Farallon Capital Management LLC9.81%6,348,906862.82MJun 29, 2026
RTW Investments LP7.82%5,061,175687.81MJun 29, 2026
Vanguard Portfolio Management LLC5.61%3,629,298493.22MJun 29, 2026
Wellington Management Group, LLP5.28%3,416,781464.34MJun 29, 2026
UBS Group AG5.25%3,399,221461.95MJun 29, 2026

Fund ownership

PTGX fund ownership
Holder% heldSharesValueReported
iShares Trust-iShares Core S&P Small-Cap ETF5.96%3,854,840523.87MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund3.16%2,044,938277.91MJun 29, 2026
iShares Trust-iShares Russell 2000 ETF2.46%1,594,175216.65MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund2.28%1,475,422200.51MJun 29, 2026
VANGUARD SPECIALIZED FUNDS-Vanguard Health Care Fund1.92%1,243,618169.01MJul 30, 2026
SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF1.57%1,013,552137.74MSep 29, 2026