OPKO Health, Inc. OPK
Set alert
At close · Oct 30
After hours · Oct 30, 7:48 PM ET
- YTD
- +31.75%
- 1 year
- +13.70%
- Open
- 1.66
- Prev close
- 1.66
- Mkt cap
- 1.24B
- Vol
- 2.15M
- Avg vol
- 3.59M
- EPS
- -0.09
- P/E
- 0.00
- Div yield
- 0.00%
More statistics
- Low
- 1.64
- High
- 1.69
- Forward P/E
- -4.83
- Beta
- 1.50
- Short ratio
- 7.73
- Inst. own
- 27.61%
- Dividend
- 0.00
- Ex-div date
- Earnings
- Nov 4, 2026
- 50-d avg
- 1.56
- 200-d avg
- 1.34
- 1y target
- 4.15
2Y chart
Events in this range
- Jul 31, 2025Earnings: -0.19; estimate -0.12; surprise -58.33%
- Oct 29, 2025Earnings: 0.03; estimate -0.02; surprise 250%
- Oct 31, 2025Downgrade: Jefferies · Buy → Hold
- Nov 20, 2025Rating: JP Morgan · — → Neutral
- Feb 26, 2026Earnings: -0.04; estimate -0.07; surprise 42.86%
- Mar 2, 2026Rating: Barrington Research · Outperform → Outperform
- Apr 28, 2026Earnings: -0.07; estimate -0.07; surprise 0%
- Apr 29, 2026Downgrade: Barrington Research · Outperform → Market Perform
- Jul 27, 2026Earnings: -0.01; estimate -0.08; surprise 87.5%
- Oct 16, 2026Rating: Barrington Research · Market Perform → Outperform
- Oct 16, 2026Rating: Piper Sandler · Overweight → Overweight
Signals (81)
| Name | Date | Ago |
|---|---|---|
| MACD: Buy Signal | Oct 19, 2026 | 1 week ago |
| SMA: Bullish | Oct 15, 2026 | 2 weeks ago |
| SMA: Bullish | Oct 14, 2026 | 2 weeks ago |
| SMA: Bearish | Oct 13, 2026 | 2 weeks ago |
| RSI: Oversold | Oct 13, 2026 | 2 weeks ago |
| SMA: Bearish | Oct 6, 2026 | 3 weeks ago |
| MACD: Sell Signal | Sep 25, 2026 | 1 month ago |
| MACD: Buy Signal | Sep 18, 2026 | 1 month ago |
| MACD: Sell Signal | Sep 10, 2026 | 1 month ago |
| RSI: Overbought | Sep 2, 2026 | 1 month ago |
| SMA: Bullish | Aug 19, 2026 | 2 months ago |
| SMA: Bullish | Aug 10, 2026 | 2 months ago |
| SMA: Bullish | Jul 28, 2026 | 3 months ago |
| SMA: Bullish | Jul 28, 2026 | 3 months ago |
| MACD: Buy Signal | Jul 28, 2026 | 3 months ago |
| RSI: Overbought | Jul 28, 2026 | 3 months ago |
| SMA: Bearish | Jul 13, 2026 | 3 months ago |
| SMA: Bearish | Jul 13, 2026 | 3 months ago |
| RSI: Oversold | Jul 13, 2026 | 3 months ago |
| MACD: Sell Signal | Jul 2, 2026 | 4 months ago |
| RSI: Overbought | Jul 1, 2026 | 4 months ago |
| MACD: Buy Signal | Jun 26, 2026 | 4 months ago |
| RSI: Overbought | Jun 24, 2026 | 4 months ago |
| MACD: Sell Signal | Jun 15, 2026 | 4 months ago |
| RSI: Overbought | Jun 11, 2026 | 4 months ago |
| RSI: Overbought | Jun 3, 2026 | 5 months ago |
| RSI: Overbought | May 28, 2026 | 5 months ago |
| SMA: Bullish | May 20, 2026 | 5 months ago |
| MACD: Buy Signal | May 19, 2026 | 5 months ago |
| SMA: Bearish | Apr 29, 2026 | 6 months ago |
| MACD: Sell Signal | Apr 29, 2026 | 6 months ago |
| MACD: Buy Signal | Apr 6, 2026 | 6 months ago |
| MACD: Sell Signal | Mar 27, 2026 | 7 months ago |
| MACD: Buy Signal | Mar 25, 2026 | 7 months ago |
| MACD: Sell Signal | Mar 20, 2026 | 7 months ago |
| MACD: Buy Signal | Mar 2, 2026 | 8 months ago |
| MACD: Sell Signal | Jan 27, 2026 | 9 months ago |
| SMA: Bearish | Jan 22, 2026 | 9 months ago |
| SMA: Bullish | Jan 21, 2026 | 9 months ago |
| SMA: Bullish | Jan 21, 2026 | 9 months ago |
| MACD: Buy Signal | Jan 21, 2026 | 9 months ago |
| MACD: Sell Signal | Jan 16, 2026 | 9 months ago |
| SMA: Bearish | Jan 14, 2026 | 9 months ago |
| SMA: Bullish | Jan 7, 2026 | 9 months ago |
| MACD: Buy Signal | Jan 7, 2026 | 9 months ago |
| MACD: Sell Signal | Dec 18, 2025 | 10 months ago |
| MACD: Buy Signal | Nov 24, 2025 | 11 months ago |
| SMA: Bearish | Oct 27, 2025 | 1 year ago |
| SMA: Bearish | Oct 27, 2025 | 1 year ago |
| MACD: Sell Signal | Oct 13, 2025 | 1 year ago |
| SMA: Bearish | Sep 25, 2025 | 1 year ago |
| SMA: Bullish | Sep 24, 2025 | 1 year ago |
| SMA: Bearish | Sep 19, 2025 | 1 year ago |
| SMA: Bullish | Sep 18, 2025 | 1 year ago |
| MACD: Buy Signal | Sep 18, 2025 | 1 year ago |
| MACD: Sell Signal | Sep 15, 2025 | 1 year ago |
| MACD: Buy Signal | Sep 9, 2025 | 1 year ago |
| MACD: Sell Signal | Sep 4, 2025 | 1 year ago |
| SMA: Bullish | Aug 13, 2025 | 1 year ago |
| MACD: Buy Signal | Aug 13, 2025 | 1 year ago |
| RSI: Oversold | Aug 1, 2025 | 1 year ago |
| MACD: Sell Signal | Jul 29, 2025 | 1 year ago |
| MACD: Buy Signal | Jun 30, 2025 | 1 year ago |
| MACD: Sell Signal | Jun 17, 2025 | 1 year ago |
| MACD: Buy Signal | May 14, 2025 | 1 year ago |
| RSI: Oversold | May 7, 2025 | 1 year ago |
| MACD: Sell Signal | May 6, 2025 | 1 year ago |
| MACD: Buy Signal | Apr 24, 2025 | 1 year ago |
| RSI: Oversold | Apr 21, 2025 | 1 year ago |
| RSI: Oversold | Apr 10, 2025 | 1 year ago |
| RSI: Oversold | Apr 8, 2025 | 1 year ago |
| SMA: Bearish | Mar 31, 2025 | 1 year ago |
| MACD: Sell Signal | Mar 13, 2025 | 1 year ago |
| RSI: Overbought | Mar 4, 2025 | 1 year ago |
| MACD: Buy Signal | Feb 28, 2025 | 1 year ago |
| MACD: Sell Signal | Feb 27, 2025 | 1 year ago |
| RSI: Overbought | Feb 18, 2025 | 1 year ago |
| SMA: Bullish | Feb 4, 2025 | 1 year ago |
| MACD: Buy Signal | Jan 21, 2025 | 1 year ago |
| MACD: Sell Signal | Jan 15, 2025 | 1 year ago |
| MACD: Buy Signal | Jan 13, 2025 | 1 year ago |
Key statistics
- Market cap
- 1.24B
- Enterprise value
- 1.34B
- Trailing P/E
- 0.00
- Forward P/E
- -4.83
- PEG ratio
- 93.65
- Price / sales
- 2.11
- Price / book
- 1.05
- EPS (TTM)
- -0.09
- Beta
- 1.50
- Dividend yield
- 0.00%
- Payout ratio
- 0.00%
- Profit margin
- -12.40%
- Revenue (TTM)
- 587.90M
- Revenue growth
- 4.30%
- Free cash flow
- 54.76M
- Total cash
- 300.76M
- Total debt
- 398.08M
- Return on equity
- -5.88%
- Shares outstanding
- 746.33M
- Short % of float
- 8.20%
- 50-day average
- 1.56
- 200-day average
- 1.34
Analyst view
Consensus: buy
- Target (low)
- 2.25
- Target (mean)
- 4.15
- Target (high)
- 8.50
- Strong buy3
- Buy2
- Hold1
- Sell0
- Strong sell0
Next earnings
Nov 4, 2026
Expected Nov 4, 2026. Consensus EPS estimate -0.06333.
Financials — quick view
Earnings
| Report date | Quarter ending | EPS estimate | EPS reported | Surprise | Surprise % |
|---|---|---|---|---|---|
| Nov 4, 2026 | Sep 30, 2026 | -0.068 | — | — | — |
| Jul 27, 2026 | Jun 30, 2026 | -0.08 | -0.01 | +0.07 | +87.50% |
| Apr 28, 2026 | Mar 31, 2026 | -0.07 | -0.07 | 0.00 | 0.00% |
| Feb 26, 2026 | Dec 31, 2025 | -0.07 | -0.04 | +0.03 | +42.86% |
| Oct 29, 2025 | Sep 30, 2025 | -0.02 | 0.03 | +0.05 | +250.00% |
| Jul 31, 2025 | Jun 30, 2025 | -0.12 | -0.19 | -0.07 | -58.33% |
Upgrades / downgrades
| Date | Firm | Action | From | To |
|---|---|---|---|---|
| Oct 16, 2026 | Piper Sandler | reit | Overweight | Overweight |
| Oct 16, 2026 | Barrington Research | up | Market Perform | Outperform |
| Apr 29, 2026 | Barrington Research | down | Outperform | Market Perform |
| Mar 2, 2026 | Barrington Research | main | Outperform | Outperform |
| Nov 20, 2025 | JP Morgan | init | — | Neutral |
| Oct 31, 2025 | Jefferies | down | Buy | Hold |
About OPKO Health, Inc.
OPKO Health, Inc. operates as a healthcare company, in the United States, Ireland, Chile, Spain, Israel, Mexico, and internationally. The company operates in two segments, Pharmaceutical and Diagnostics. The Pharmaceutical segment develops MDX2001, a tetra-specific antibody targeting several types of solid tumors in Phase 1 clinical trials; MDX2003, a tetra-specific antibody targeting two antigens for hematological tumors in Phase 1 clinical trials; and MDX2004, a trispecific immune modulator to rebuild and sustain the patient's own immune system. This segment also engages in the development of Epstein Barr Virus vaccine; Rayaldee, a patented extended-release product for oral administration containing 30 mcg of a prohormone; OPK-88006 oral and injectable product to regulate blood glucose and reduce body weight; NGENLA, recombinant human growth hormone product developed for the long-term treatment of pediatric patients with growth hormone deficiency. The Diagnostics segment offers laboratory testing services, such as detection, diagnosis, evaluation, monitoring, and treatment of diseases, as well as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare under the BioReference brand; and 4Kscore test. OPKO Health, Inc. was founded in 2006 and is headquartered in Miami, Florida.
- Sector
- Healthcare
- Industry
- Diagnostics & Research
- Country
- United States
- Website
- opko.com
News
- OPKO Health to Report Third Quarter 2026 Financial Results on November 4, 2026
- OPKO Biologics Doses First Patient In Its Phase 1/2a Clinical Study Of OPK-8801001 To Treat Acromegaly
- OPKO Health's OPKO Biologics Doses First Participant in Phase 1/2a Trial of OPK-8801001 for Acromegaly
- Myriad Genetics Offloads Struggling Prenatal Unit for $210 Million to Labcorp
- Piper Sandler Reiterates Overweight on OPKO Health, Raises Price Target to $4
- OPKO Health to Sell Select BioReference Assets to Labcorp for $722M
- Ladder Capital Posts Upbeat Q3 Earnings, Joins Alcoa, Hyster-Yale And Other Big Stocks Moving Higher On Friday
- Crude Oil Moves Higher; Charles Schwab Shares Fall After Q3 Results
- OPKO Health Sheds Diagnostics Businesses in Major Labcorp Deal
- OPKO Health Sheds Diagnostics Businesses in Major Labcorp Deal
Your note
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Insider holders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| FROST PHILLIP MD ET AL | Chief Executive Officer | Purchase | Nov 20, 2025 | 0 |
| PAGANELLI JOHN A | Director | Purchase | Mar 19, 2026 | 403,515 |
Institution ownership
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| Rubric Capital Management LP | 6.40% | 47,791,243 | 79.33M | Jun 29, 2026 |
| Blackrock Inc. | 4.95% | 36,978,893 | 61.38M | Jun 29, 2026 |
| Vanguard Capital Management LLC | 2.01% | 14,968,930 | 24.85M | Jun 29, 2026 |
| Vanguard Portfolio Management LLC | 2.00% | 14,934,924 | 24.79M | Jun 29, 2026 |
| Geode Capital Management, LLC | 1.55% | 11,581,027 | 19.22M | Jun 29, 2026 |
| State Street Corporation | 1.38% | 10,309,070 | 17.11M | Jun 29, 2026 |
Fund ownership
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| iShares Trust-iShares Russell 2000 ETF | 1.38% | 10,318,703 | 17.13M | Sep 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund | 1.31% | 9,753,393 | 16.19M | Jun 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund | 0.93% | 6,919,876 | 11.49M | Jun 29, 2026 |
| VANGUARD INDEX FUNDS-Vanguard Extended Market Index Fund | 0.66% | 4,914,746 | 8.16M | Jun 29, 2026 |
| Fidelity Salem Street Trust-Fidelity Small Cap Index Fund | 0.58% | 4,352,343 | 7.22M | Jul 30, 2026 |
| iShares Trust-iShares Russell 2000 Value ETF | 0.50% | 3,736,435 | 6.20M | Sep 29, 2026 |