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Karyopharm Therapeutics Inc. KPTI

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Price alert · KPTI

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0.05 USD -0.02 (-28.12%)

Nov 5, 2026, 10:58 AM EST

0.0501 Day range 0.0575
0.0501 52-week range 10.99
YTD
-99.29%
1 year
-99.02%

Financial health

Altman Z-Score

-27.45 Distress zone

Bankruptcy-risk model: below 1.81 distress, above 2.99 safe.

Piotroski F-Score

2 / 9 Weak

Nine pass/fail tests of profitability, leverage and efficiency.

FMP rating

B-2 / 5 overall

  • DCF 5
  • Return on Equity 5
  • Return on Assets 1
  • Debt / Equity 1
  • P/E 1
  • P/B 1

Valuation

P/E -0.4×
FY 2016: -3.2×FY 2017: -3.4×FY 2018: -3.0×FY 2019: -5.9×FY 2020: -5.7×FY 2021: -3.9×FY 2022: -1.7×FY 2023: -0.7×FY 2024: -1.1×FY 2025: -0.4×
FY 2016 5y median -1.1× FY 2025
P/S 0.6×
FY 2016: 2288×FY 2017: 274×FY 2018: 17.5×FY 2019: 29.0×FY 2020: 10.3×FY 2021: 2.3×FY 2022: 1.8×FY 2023: 0.7×FY 2024: 0.6×FY 2025: 0.6×
FY 2016 5y median 0.7× FY 2025
P/B -0.3×
FY 2016: 2.2×FY 2017: 3.4×FY 2018: 2.9×FY 2019: 23.8×FY 2020: 22.0×FY 2021: -6.1×FY 2022: -16.7×FY 2023: -0.7×FY 2024: -0.4×FY 2025: -0.3×
FY 2016 5y median -0.7× FY 2025
P/FCF -1.1×
FY 2016: -4.2×FY 2017: -6.0×FY 2018: -3.3×FY 2019: -6.2×FY 2020: -6.9×FY 2021: -4.3×FY 2022: -1.9×FY 2023: -1.1×FY 2024: -0.6×FY 2025: -1.1×
FY 2016 5y median -1.1× FY 2025
EV/EBITDA -1.7×
FY 2016: -2.8×FY 2017: -2.9×FY 2018: -2.9×FY 2019: -6.5×FY 2020: -6.9×FY 2021: -4.9×FY 2022: -2.3×FY 2023: -1.9×FY 2024: -5.6×FY 2025: -1.7×
FY 2016 5y median -2.3× FY 2025
EV/Sales 1.7×
FY 2016: 1965×FY 2017: 231×FY 2018: 17.0×FY 2019: 28.9×FY 2020: 10.7×FY 2021: 2.3×FY 2022: 2.1×FY 2023: 1.5×FY 2024: 1.5×FY 2025: 1.7×
FY 2016 5y median 1.7× FY 2025
FCF Yield -93.6%
FY 2016: -24.0%FY 2017: -16.8%FY 2018: -30.4%FY 2019: -16.1%FY 2020: -14.4%FY 2021: -23.4%FY 2022: -53.8%FY 2023: -93.8%FY 2024: -154.9%FY 2025: -93.6%
FY 2016 5y median -93.6% FY 2025

Profitability

Gross Margin 95.9%
FY 2016: -56353.2%FY 2017: -6583.7%FY 2018: -431.9%FY 2019: 94.1%FY 2020: 97.5%FY 2021: 98.4%FY 2022: 96.7%FY 2023: 96.6%FY 2024: 95.9%FY 2025: 95.9%
FY 2016 5y median 96.6% FY 2025
Operating Margin -62.1%
FY 2016: -71903.9%FY 2017: -8133.2%FY 2018: -593.0%FY 2019: -462.9%FY 2020: -159.0%FY 2021: -46.8%FY 2022: -90.5%FY 2023: -88.7%FY 2024: -82.2%FY 2025: -62.1%
FY 2016 5y median -82.2% FY 2025
Net Margin -134.2%
FY 2016: -71153.9%FY 2017: -8036.4%FY 2018: -588.1%FY 2019: -488.1%FY 2020: -181.6%FY 2021: -59.1%FY 2022: -105.2%FY 2023: -98.0%FY 2024: -52.6%FY 2025: -134.2%
FY 2016 5y median -98.0% FY 2025
ROE 66.9%
FY 2016: -67.5%FY 2017: -99.6%FY 2018: -97.4%FY 2019: -401.0%FY 2020: -388.3%FY 2021: 155.7%FY 2022: 992.4%FY 2023: 105.1%FY 2024: 41.1%FY 2025: 66.9%
FY 2016 5y median 105.1% FY 2025
ROIC -236.6%
FY 2016: -67.6%FY 2017: -99.8%FY 2018: -61.1%FY 2019: -75.6%FY 2020: -67.5%FY 2021: -42.0%FY 2022: -48.2%FY 2023: -74.3%FY 2024: -123.1%FY 2025: -236.6%
FY 2016 5y median -74.3% FY 2025
ROA -180.8%
FY 2016: -60.7%FY 2017: -71.5%FY 2018: -52.3%FY 2019: -67.7%FY 2020: -62.7%FY 2021: -40.6%FY 2022: -46.1%FY 2023: -59.5%FY 2024: -46.5%FY 2025: -180.8%
FY 2016 5y median -46.5% FY 2025

Growth (YoY)

Revenue 0.6%
FY 2016: -38.4%FY 2017: 942.2%FY 2018: 1790.1%FY 2019: 34.8%FY 2020: 164.3%FY 2021: 94.1%FY 2022: -25.1%FY 2023: -7.0%FY 2024: -0.5%FY 2025: 0.6%
FY 2016 FY 2025
Operating Income 24.1%
FY 2016: 7.0%FY 2017: -17.9%FY 2018: -37.8%FY 2019: -5.2%FY 2020: 9.2%FY 2021: 42.8%FY 2022: -44.7%FY 2023: 8.9%FY 2024: 7.8%FY 2025: 24.1%
FY 2016 FY 2025
EPS (diluted) -90.5%
FY 2016: 12.0%FY 2017: 3.8%FY 2018: -11.8%FY 2019: -2.6%FY 2020: 15.4%FY 2021: 39.4%FY 2022: -22.3%FY 2023: 37.9%FY 2024: 49.9%FY 2025: -90.5%
FY 2016 FY 2025
Free Cash Flow 40.9%
FY 2016: 11.5%FY 2017: 12.6%FY 2018: -118.9%FY 2019: -18.3%FY 2020: 16.0%FY 2021: 29.6%FY 2022: -32.7%FY 2023: 38.0%FY 2024: -37.6%FY 2025: 40.9%
FY 2016 FY 2025

Financial Health

Current Ratio 1.1×
FY 2016: 8.0×FY 2017: 3.0×FY 2018: 7.1×FY 2019: 6.0×FY 2020: 4.6×FY 2021: 3.7×FY 2022: 5.3×FY 2023: 3.4×FY 2024: 1.7×FY 2025: 1.1×
FY 2016 5y median 3.4× FY 2025
Quick Ratio 1.1×
FY 2016: 8.0×FY 2017: 3.0×FY 2018: 7.1×FY 2019: 6.0×FY 2020: 4.5×FY 2021: 3.7×FY 2022: 5.2×FY 2023: 3.3×FY 2024: 1.6×FY 2025: 1.1×
FY 2016 5y median 3.3× FY 2025
Debt / Equity -0.8×
FY 2016: 0.0×FY 2017: 0.0×FY 2018: 0.6×FY 2019: 2.5×FY 2020: 2.6×FY 2021: -2.3×FY 2022: -10.8×FY 2023: -1.3×FY 2024: -1.0×FY 2025: -0.8×
FY 2016 5y median -1.3× FY 2025
Net Debt / EBITDA -1.2×
FY 2016: 0.5×FY 2017: 0.5×FY 2018: 0.1×FY 2019: 0.0×FY 2020: -0.3×FY 2021: 0.1×FY 2022: -0.3×FY 2023: -1.1×FY 2024: -3.4×FY 2025: -1.2×
FY 2016 5y median -1.1× FY 2025
Interest Coverage -2.0×
FY 2016: 0.0×FY 2017: 0.0×FY 2018: -72.2×FY 2019: -12.1×FY 2020: -6.3×FY 2021: -3.8×FY 2022: -5.7×FY 2023: -5.4×FY 2024: -3.2×FY 2025: -2.0×
FY 2016 5y median -3.8× FY 2025

Dividends

Dividend Yield 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025
Payout Ratio 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025

Annual · latest fiscal year ends 2025-12-31