Centessa Pharmaceuticals plc CNTA
Set alert
At close · Jun 25
After hours · Jun 25, 4:00 PM ET
- YTD
- +61.94%
- 1 year
- +201.56%
- Open
- 40.50
- Prev close
- 40.50
- Mkt cap
- 6.27B
- Vol
- 0
- Avg vol
- 2.15M
- EPS
- -1.79
- P/E
- -22.75
- Div yield
- 0.00%
More statistics
- Low
- 40.50
- High
- 40.50
- Beta
- 1.12
- Inst. own
- 96.93%
- Dividend
- 38.00
- Earnings
- Aug 11, 2026
2Y chart
Events in this range
- May 14, 2025Earnings: -0.2; estimate -0.35; surprise 42.86%
- Aug 12, 2025Earnings: -0.38; estimate -0.35; surprise -8.57%
- Nov 5, 2025Earnings: -0.41; estimate -0.39; surprise -5.13%
- Feb 24, 2026Rating: Wolfe Research · — → Outperform
- Mar 31, 2026Earnings: -0.48; estimate -0.37144; surprise -29.23%
- Mar 31, 2026Downgrade: Needham · Buy → Hold
- Mar 31, 2026Downgrade: Wolfe Research · Outperform → Peer Perform
- Apr 1, 2026Downgrade: Leerink Partners · Outperform → Market Perform
- Apr 2, 2026Downgrade: Guggenheim · Buy → Neutral
- Apr 20, 2026Downgrade: Wells Fargo · Overweight → Equal-Weight
- May 5, 2026Earnings: -0.52; estimate -0.38; surprise -36.84%
- Jun 24, 2026Dividend: 38
Signals (91)
| Name | Date | Ago |
|---|---|---|
| MACD: Buy Signal | Jun 24, 2026 | 4 months ago |
| RSI: Overbought | Jun 22, 2026 | 4 months ago |
| MACD: Sell Signal | Apr 20, 2026 | 6 months ago |
| MACD: Buy Signal | Mar 31, 2026 | 7 months ago |
| RSI: Overbought | Mar 31, 2026 | 7 months ago |
| MACD: Sell Signal | Mar 30, 2026 | 7 months ago |
| MACD: Buy Signal | Mar 26, 2026 | 7 months ago |
| MACD: Sell Signal | Mar 23, 2026 | 7 months ago |
| SMA: Bullish | Feb 23, 2026 | 8 months ago |
| SMA: Bearish | Feb 20, 2026 | 8 months ago |
| SMA: Bullish | Feb 17, 2026 | 8 months ago |
| MACD: Buy Signal | Feb 13, 2026 | 8 months ago |
| MACD: Sell Signal | Feb 9, 2026 | 8 months ago |
| SMA: Bearish | Jan 28, 2026 | 9 months ago |
| SMA: Bullish | Jan 27, 2026 | 9 months ago |
| MACD: Buy Signal | Jan 21, 2026 | 9 months ago |
| RSI: Oversold | Jan 12, 2026 | 9 months ago |
| RSI: Oversold | Jan 8, 2026 | 9 months ago |
| SMA: Bearish | Dec 17, 2025 | 10 months ago |
| MACD: Sell Signal | Dec 9, 2025 | 10 months ago |
| RSI: Overbought | Nov 24, 2025 | 11 months ago |
| MACD: Buy Signal | Nov 13, 2025 | 11 months ago |
| SMA: Bullish | Nov 11, 2025 | 11 months ago |
| SMA: Bearish | Nov 7, 2025 | 11 months ago |
| MACD: Sell Signal | Nov 3, 2025 | 12 months ago |
| MACD: Buy Signal | Oct 27, 2025 | 1 year ago |
| MACD: Sell Signal | Oct 1, 2025 | 1 year ago |
| RSI: Overbought | Sep 29, 2025 | 1 year ago |
| RSI: Overbought | Sep 18, 2025 | 1 year ago |
| MACD: Buy Signal | Sep 9, 2025 | 1 year ago |
| RSI: Overbought | Sep 9, 2025 | 1 year ago |
| SMA: Bullish | Sep 8, 2025 | 1 year ago |
| SMA: Bearish | Sep 4, 2025 | 1 year ago |
| MACD: Sell Signal | Aug 19, 2025 | 1 year ago |
| MACD: Buy Signal | Aug 15, 2025 | 1 year ago |
| MACD: Sell Signal | Aug 11, 2025 | 1 year ago |
| MACD: Buy Signal | Jul 31, 2025 | 1 year ago |
| RSI: Overbought | Jul 31, 2025 | 1 year ago |
| MACD: Sell Signal | Jul 28, 2025 | 1 year ago |
| RSI: Overbought | Jul 21, 2025 | 1 year ago |
| SMA: Bullish | Jul 16, 2025 | 1 year ago |
| RSI: Overbought | Jul 16, 2025 | 1 year ago |
| SMA: Bullish | Jun 23, 2025 | 1 year ago |
| SMA: Bearish | Jun 20, 2025 | 1 year ago |
| MACD: Buy Signal | Jun 17, 2025 | 1 year ago |
| SMA: Bullish | Jun 16, 2025 | 1 year ago |
| MACD: Sell Signal | Jun 5, 2025 | 1 year ago |
| SMA: Bearish | Jun 4, 2025 | 1 year ago |
| SMA: Bullish | May 30, 2025 | 1 year ago |
| MACD: Buy Signal | May 12, 2025 | 1 year ago |
| MACD: Sell Signal | May 9, 2025 | 1 year ago |
| MACD: Buy Signal | Apr 17, 2025 | 1 year ago |
| RSI: Oversold | Apr 4, 2025 | 1 year ago |
| SMA: Bearish | Mar 25, 2025 | 1 year ago |
| SMA: Bullish | Mar 24, 2025 | 1 year ago |
| MACD: Sell Signal | Mar 21, 2025 | 1 year ago |
| SMA: Bearish | Mar 20, 2025 | 1 year ago |
| SMA: Bullish | Mar 12, 2025 | 1 year ago |
| SMA: Bearish | Mar 7, 2025 | 1 year ago |
| MACD: Buy Signal | Mar 6, 2025 | 1 year ago |
| SMA: Bullish | Mar 5, 2025 | 1 year ago |
| SMA: Bearish | Feb 18, 2025 | 1 year ago |
| MACD: Sell Signal | Feb 18, 2025 | 1 year ago |
| SMA: Bullish | Feb 5, 2025 | 1 year ago |
| SMA: Bearish | Feb 4, 2025 | 1 year ago |
| SMA: Bullish | Jan 29, 2025 | 1 year ago |
| MACD: Buy Signal | Jan 23, 2025 | 1 year ago |
| SMA: Bearish | Jan 8, 2025 | 1 year ago |
| SMA: Bullish | Jan 7, 2025 | 1 year ago |
| SMA: Bearish | Jan 6, 2025 | 1 year ago |
| SMA: Bullish | Dec 31, 2024 | 1 year ago |
| SMA: Bearish | Dec 30, 2024 | 1 year ago |
| SMA: Bullish | Dec 19, 2024 | 1 year ago |
| SMA: Bearish | Dec 18, 2024 | 1 year ago |
| MACD: Sell Signal | Dec 10, 2024 | 1 year ago |
| MACD: Buy Signal | Dec 6, 2024 | 1 year ago |
| MACD: Sell Signal | Dec 3, 2024 | 1 year ago |
| RSI: Overbought | Nov 13, 2024 | 1 year ago |
| MACD: Buy Signal | Nov 7, 2024 | 1 year ago |
| SMA: Bullish | Nov 1, 2024 | 1 year ago |
| SMA: Bearish | Oct 30, 2024 | 2 years ago |
| MACD: Sell Signal | Sep 23, 2024 | 2 years ago |
| RSI: Overbought | Sep 13, 2024 | 2 years ago |
| MACD: Buy Signal | Sep 12, 2024 | 2 years ago |
| MACD: Sell Signal | Sep 11, 2024 | 2 years ago |
| RSI: Overbought | Sep 9, 2024 | 2 years ago |
| RSI: Overbought | Sep 4, 2024 | 2 years ago |
| RSI: Overbought | Aug 26, 2024 | 2 years ago |
| RSI: Overbought | Aug 14, 2024 | 2 years ago |
| RSI: Overbought | Aug 8, 2024 | 2 years ago |
| RSI: Overbought | Jul 26, 2024 | 2 years ago |
Key statistics
- Market cap
- 6.27B
- Enterprise value
- 6.21B
- Trailing P/E
- -22.75
- PEG ratio
- 3.15
- Price / sales
- 0.00
- Price / book
- 12.76
- Beta
- 1.12
- Dividend yield
- 0.00%
- Payout ratio
- 0.00%
- Profit margin
- 0.00%
- Total cash
- 0
- Total debt
- 0
- Return on equity
- -60.37%
Analyst view
- Strong buy1
- Buy1
- Hold5
- Sell0
- Strong sell0
Next earnings
Aug 11, 2026
Expected Aug 11, 2026. Consensus EPS estimate -0.39.
Financials — quick view
Earnings
| Report date | Quarter ending | EPS estimate | EPS reported | Surprise | Surprise % |
|---|---|---|---|---|---|
| Aug 11, 2026 | Jun 30, 2026 | -0.40 | — | — | — |
| May 5, 2026 | Mar 31, 2026 | -0.38 | -0.52 | -0.14 | -36.84% |
| Mar 31, 2026 | Dec 31, 2025 | -0.37144 | -0.48 | -0.11 | -29.23% |
| Nov 5, 2025 | Sep 30, 2025 | -0.39 | -0.41 | -0.02 | -5.13% |
| Aug 12, 2025 | Jun 30, 2025 | -0.35 | -0.38 | -0.03 | -8.57% |
| May 14, 2025 | Mar 31, 2025 | -0.35 | -0.20 | +0.15 | +42.86% |
Upgrades / downgrades
| Date | Firm | Action | From | To |
|---|---|---|---|---|
| Apr 20, 2026 | Wells Fargo | down | Overweight | Equal-Weight |
| Apr 2, 2026 | Guggenheim | down | Buy | Neutral |
| Apr 1, 2026 | Leerink Partners | down | Outperform | Market Perform |
| Mar 31, 2026 | Wolfe Research | down | Outperform | Peer Perform |
| Mar 31, 2026 | Needham | down | Buy | Hold |
| Feb 24, 2026 | Wolfe Research | init | — | Outperform |
About Centessa Pharmaceuticals plc
Centessa Pharmaceuticals plc operates as a clinical-stage pharmaceutical enterprise focused on discovering, developing, and ultimately providing therapeutic solutions to patients. The company's most advanced product candidates include Lixivaptan, a small molecule inhibitor of the vasopressin V2 receptor, which is currently undergoing Phase III clinical evaluation for treating autosomal dominant polycystic kidney disease. Additionally, SerpinPC, an activated protein C inhibitor, is progressing through Phase IIa clinical development for the management of hemophilia A and B. Centessa's pipeline also features several emerging assets in the clinical proof-of-concept stage. These comprise LB101 (a PD-L1xCD47 LockBody) and LB201 (a PD-L1xCD3 LockBody), both engineered to selectively activate potent CD47 and CD3 effector functions while minimizing systemic side effects. Another molecule, ZF874, is a small molecule pharmacological chaperone in Phase I studies, designed to correct the misfolding of the Z variant of alpha-1-antitrypsin, thus addressing alpha-1-antitrypsin deficiency. Furthermore, MGX292, a recombinant modified BMP9 replacement protein, aims to rectify the deficient BMP9 signaling implicated in Pulmonary Arterial Hypertension. The company is also developing OX2R Agonists, which are selective orexin receptor 2 agonists (available as oral and intranasal formulations) intended to directly target the underlying pathophysiology of orexin neuron loss in Narcolepsy Type 1 by leveraging structural insights. Beyond these, Centessa is exploring further clinical proof-of-concept compounds. CBS001, an anti-LIGHT antibody, is being investigated for inflammatory and fibrotic diseases due to its preferential binding to the inflammatory membrane form of LIGHT. Lastly, CBS004 is a humanized monoclonal antibody specifically targeting BDCA2, a protein found exclusively on plasmacytoid dendritic cells, with potential utility in conditions such as systemic sclerosis, systemic lupus erythematosus, and other autoimmune disorders. Centessa Pharmaceuticals plc was established in 2020 and is headquartered in Altrincham, United Kingdom.
- Sector
- Healthcare
- Industry
- Biotechnology
- Country
- GB
- Employees
- 129
- Website
- centessa.com
News
- Global UAV Announces Proposed Acquisition of Nexus Peptide Sciences Inc.
- Acquisition of Centessa by Lilly Approved by the High Court of Justice of England and Wales
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- Actinium Appoints Accomplished Oncology Expert Steffen Heeger MD, MSc as Chief Medical Officer to Drive Rejuvenated Pipeline Development
- Are CNTA, WSR, GDOT Obtaining Fair Deals for their Shareholders?
- Centessa Pharmaceuticals Investor Alert: Kahn Swick & Foti, LLC Investigates Adequacy of Price and Process in Proposed Sale of Centessa Pharmaceuticals plc - CNTA
- 38,432 Shares in Centessa Pharmaceuticals PLC Sponsored ADR $CNTA Acquired by B. Metzler seel. Sohn & Co. AG
- Here Are Monday’s Top Wall Street Analyst Research Calls: Adobe, Best Buy, Bilibili, Constellation Brands, CoreWeave, Nike, Starbucks, T-Mobile, and More
- Are APLS, CNTA, KZR Obtaining Fair Deals for their Shareholders?
- Shareholder Alert: The Ademi Firm investigates whether Centessa Pharmaceuticals plc is obtaining a Fair Price for Public Shareholders
Your note
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Insider holders
| Insider | Relation | Latest transaction | Date | Shares held |
|---|---|---|---|---|
| ACCARDI MARIO ALBERTO | Chief Executive Officer | Stock Award(Grant) | Feb 1, 2026 | 243,886 |
| ANDERSON KAREN M | Officer | Sale | Mar 25, 2026 | 62,085 |
| BUSH TIA L | Chief Technology Officer | Stock Award(Grant) | Feb 1, 2026 | 147,954 |
| CHAO DAVID M | Officer | Sale | Mar 16, 2025 | 225,007 |
| CROWLEY JOHN JOSEPH CPA | Chief Financial Officer | Stock Award(Grant) | Feb 1, 2026 | 45,000 |
| GOYAL ARJUN | Director | Purchase | May 15, 2025 | 0 |
Institution ownership
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| Medicxi Ventures Management (Jersey) Ltd | 12.90% | 19,963,157 | 808.51M | Mar 30, 2026 |
| Avoro Capital Advisors LLC | 7.39% | 11,430,455 | 462.93M | Mar 30, 2026 |
| Index Venture Life Associates VI Ltd | 6.44% | 9,961,789 | 403.45M | Mar 30, 2026 |
| Adage Capital Partners GP L.L.C. | 5.77% | 8,925,010 | 361.46M | Mar 30, 2026 |
| Pentwater Capital Management Lp | 5.28% | 8,170,000 | 330.88M | Mar 30, 2026 |
| FMR, LLC | 4.43% | 6,852,047 | 277.51M | Mar 30, 2026 |
Fund ownership
| Holder | % held | Shares | Value | Reported |
|---|---|---|---|---|
| SmallCap World Fund Inc | 2.86% | 4,422,431 | 179.11M | Mar 30, 2026 |
| T. Rowe Price Health Sciences Fund, Inc. | 0.88% | 1,367,577 | 55.39M | Mar 30, 2026 |
| Fidelity Contrafund | 0.85% | 1,321,353 | 53.51M | Apr 29, 2026 |
| Federated Hermes Equity Funds-Federated Hermes Kaufmann Fund | 0.80% | 1,236,100 | 50.06M | Apr 29, 2026 |
| Federated Hermes Equity Funds-Federated Hermes Kaufmann Small Cap Fund | 0.51% | 787,000 | 31.87M | Apr 29, 2026 |
| MUTUAL FUND SERIES TRUST-Eventide Healthcare & Life Sciences Fund | 0.43% | 668,142 | 27.06M | Mar 30, 2026 |