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State Street SPDR S&P Biotech ETF XBI

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Price alert · XBI

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152.21 USD +3.81 (+2.57%)

At closeNov 6, 2026, 7:22 PM EST

152.31 +0.10 +0.07%

After hours · Nov 6, 7:22 PM ET

147.56 Day range 152.92
108.96 52-week range 169.55
YTD
+24.83%
1 year
+39.27%

State Street SPDR S&P Biotech ETF

Issuer
SPDR
Asset class
Equity
Expense ratio
0.35%
Assets under management
$10.03B
NAV
148.54
Holdings
165
Inception
2006-01-31
Top 10 weight
18.42%

Top holdings

  1. MRNA MODERNA INC 2.71%
  2. EXEL EXELIXIS INC 1.80%
  3. AMGN AMGEN INC 1.79%
  4. BIIB BIOGEN INC 1.76%
  5. GILD GILEAD SCIENCES INC 1.75%
  6. ABBV ABBVIE INC 1.75%
  7. HALO HALOZYME THERAPEUTICS INC 1.75%
  8. REGN REGENERON PHARMACEUTICALS 1.70%
  9. UTHR UNITED THERAPEUTICS CORP 1.70%
  10. SYRE SPYRE THERAPEUTICS INC 1.69%
  11. NTRA NATERA INC 1.68%
  12. TGTX TG THERAPEUTICS INC 1.62%
  13. ORKA ORUKA THERAPEUTICS INC 1.60%
  14. VRTX VERTEX PHARMACEUTICALS INC 1.59%
  15. NBIX NEUROCRINE BIOSCIENCES INC 1.57%
  16. ALKS ALKERMES PLC 1.50%
  17. BBIO BRIDGEBIO PHARMA INC 1.49%
  18. PTCT PTC THERAPEUTICS INC 1.48%
  19. TWST TWIST BIOSCIENCE CORP 1.46%
  20. INCY INCYTE CORP 1.43%
  21. KYMR KYMERA THERAPEUTICS INC 1.41%
  22. PTGX PROTAGONIST THERAPEUTICS INC 1.41%
  23. CRSP CRISPR THERAPEUTICS AG 1.36%
  24. ROIV ROIVANT SCIENCES LTD 1.34%
  25. BMRN BIOMARIN PHARMACEUTICAL INC 1.33%

Sector weights

  • Healthcare 99.47%
  • Financial Services 0.53%

Country weights

  • United States 96.79%
  • Switzerland 1.35%
  • United Kingdom 1.26%
  • Netherlands 0.48%
  • Ireland 0.07%
  • China 0.04%

Updated 2026-11-07