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State Street SPDR S&P Biotech ETF XBI

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152.21 USD +3.81 (+2.57%)

At closeNov 6, 2026, 7:22 PM EST

152.31 +0.10 +0.07%

After hours · Nov 6, 7:22 PM ET

147.56 Day range 152.92

108.96 52-week range 169.55

YTD: +24.83%
1 year: +39.27%

Issuer: SPDR
Asset class: Equity
Expense ratio: 0.35%
Assets under management: $10.88B
NAV: 159.15
Holdings: 165
Inception: 2006-01-31
Top 10 weight: 18.42%

MRNA MODERNA INC 2.71%
EXEL EXELIXIS INC 1.80%
AMGN AMGEN INC 1.79%
BIIB BIOGEN INC 1.76%
GILD GILEAD SCIENCES INC 1.75%
ABBV ABBVIE INC 1.75%
HALO HALOZYME THERAPEUTICS INC 1.75%
REGN REGENERON PHARMACEUTICALS 1.70%
UTHR UNITED THERAPEUTICS CORP 1.70%
SYRE SPYRE THERAPEUTICS INC 1.69%
NTRA NATERA INC 1.68%
TGTX TG THERAPEUTICS INC 1.62%
ORKA ORUKA THERAPEUTICS INC 1.60%
VRTX VERTEX PHARMACEUTICALS INC 1.59%
NBIX NEUROCRINE BIOSCIENCES INC 1.57%
ALKS ALKERMES PLC 1.50%
BBIO BRIDGEBIO PHARMA INC 1.49%
PTCT PTC THERAPEUTICS INC 1.48%
TWST TWIST BIOSCIENCE CORP 1.46%
INCY INCYTE CORP 1.43%
KYMR KYMERA THERAPEUTICS INC 1.41%
PTGX PROTAGONIST THERAPEUTICS INC 1.41%
CRSP CRISPR THERAPEUTICS AG 1.36%
ROIV ROIVANT SCIENCES LTD 1.34%
BMRN BIOMARIN PHARMACEUTICAL INC 1.33%

Healthcare 99.28%
Financial Services 0.72%

United States 96.79%
Switzerland 1.35%
United Kingdom 1.26%
Netherlands 0.48%
Ireland 0.07%
China 0.04%

Updated 2026-11-05

Funds holding XBI, by value held
Fund	Value held	Weight in fund
MKLOX	$25.24M	0.14%
BDYN	$11.66M	0.37%
EMPB	$5.38M	16.78%
TIH	$3.05M	0.49%
TSCV	$2.09M	1.18%
XNAV	$1.04M	3.82%
GEQ	$908.85K	0.46%
WLTG	$715.44K	0.97%
HFEQ	$289.23K	2.46%
HFND	$210.88K	0.59%
NSCS	$73.67K	0.85%
PSTR	$66.06K	0.10%
SECA	$50.23K	0.01%