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Rhythm Pharmaceuticals, Inc. RYTM

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114.61 USD +0.67 (+0.59%)

Nov 10, 2026, 2:52 PM EST

112.51 Day range 114.95
74.50 52-week range 122.20
YTD
+7.07%
1 year
+17.39%
Market cap
7.94B
Revenue (ttm)
280.75M
Profit margin
-69.03%
EPS (ttm)
-2.91
Shares out
69.33M
Forward P/E
-87.77
YTD return
+7.07%
1-year return
+17.39%
Volume
315.61K
Avg volume
989.70K
Open
113.42
Previous close
113.94
Day's range
112.51 – 114.95
52-week range
74.50 – 122.20
Beta
2.13
Analysts
Strong Buy
Price target
140.12 (+22.3%)
Earnings date
Feb 25, 2027

5D +27.71 (+32.05%)

90100110WedThuFriMonTue114.17

Key statistics

Enterprise value
7.68B
PEG ratio
0.00
Price / sales
28.14
Price / book
89.79
Dividend yield
0.00%
Payout ratio
0.00%
Revenue growth
79.60%
Free cash flow
-17.76M
Total cash
320.94M
Total debt
106.18M
Return on equity
-77.96%
Short % of float
16.00%
50-day average
96.15
200-day average
97.01

Financials — quick view

All financials
RYTM Revenue — quarterly 92.13M
2022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 20262026-Q3 2026
RYTM Net income — quarterly -41.37M
2022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 20262026-Q3 2026
RYTM EPS — quarterly -0.61
2022-Q4 20222023-Q1 20232023-Q2 20232023-Q3 20232023-Q4 20232024-Q1 20242024-Q2 20242024-Q3 20242024-Q4 20242025-Q1 20252025-Q2 20252025-Q3 20252025-Q4 20252026-Q1 20262026-Q2 20262026-Q3 2026

Earnings

RYTM recent earnings
Report dateQuarter endingEPS estimateEPS reportedSurpriseSurprise %
Feb 25, 2027Dec 30, 2026-2.23———
Nov 3, 2026Sep 30, 2026-0.70968-0.61+0.10+14.05%
Aug 4, 2026Jun 30, 2026-0.80721-0.73+0.08+9.57%
May 5, 2026Mar 31, 2026-0.86-0.83+0.03+3.49%
Feb 26, 2026Dec 31, 2025-0.79-0.73+0.06+7.59%
Nov 4, 2025Sep 30, 2025-0.72-0.82-0.10-13.89%

Upgrades / downgrades

RYTM analyst upgrades and downgrades
DateFirmActionFromTo
Nov 6, 2026JP MorganmainOverweightOverweight
Nov 5, 2026GuggenheimmainBuyBuy
Nov 4, 2026CitizensmainMarket OutperformMarket Outperform
Nov 3, 2026NeedhammainBuyBuy
Oct 16, 2026William Blairinit—Outperform
Oct 15, 2026JP MorganmainOverweightOverweight

About Rhythm Pharmaceuticals, Inc.

Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases in the United States and internationally. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, Bardet-Biedl and Alström syndrome, Prader-Willi syndrome, and hypothalamic obesity. It is in Phase 3 clinical trials for treating acquired hypothalamic obesity, congenital hypothalamic obesity, pro-opiomelanocortin (POMC) and LEPR insufficiency obesities, SRC1 deficiency obesity, and SH2B1 deficiency obesity; and in phase 2 clinical trails for the treatment of Prader-Willi syndrome and MC4R deficiency. The company is also developing bivamelagon, an investigational oral small molecule MC4R agonist that is in phase 2 clinical trial for the treatment of MC4R pathway diseases; and RM-718, a next generation MC4R peptide agonist that is in phase 1 clinical trial for the treatment of hypothalamic obesity. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.

Sector
Healthcare
Industry
Biotechnology
Country
United States
Website
rhythmtx.com

News

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Insider holders

RYTM insider holders
InsiderRelationLatest transactionDateShares held
CRAMER PAMELA J.OfficerConversion of Exercise of derivative securityJan 29, 202629,376
GOOD JENNIFER LDirectorConversion of Exercise of derivative securityJun 22, 202611,712
JEAN CHRISTOPHE RDirectorConversion of Exercise of derivative securityJun 22, 202611,712
MATHERS EDWARD T.DirectorConversion of Exercise of derivative securityJun 17, 202512,771
MAZABRAUD YANNOfficerSaleAug 11, 202655,655
MCGIRR DAVID W JDirectorConversion of Exercise of derivative securityJun 22, 202611,712

Institution ownership

RYTM institution ownership
Holder% heldSharesValueReported
RA Capital Management, L.P.9.62%6,666,837759.62MJun 29, 2026
Blackrock Inc.8.88%6,156,902701.52MJun 29, 2026
Baker Bros. Advisors, LP8.08%5,604,483638.57MJun 29, 2026
Primecap Management Company4.57%3,168,853361.06MJun 29, 2026
Vanguard Portfolio Management LLC4.52%3,136,895357.42MJun 29, 2026
Vanguard Capital Management LLC4.34%3,005,977342.50MJun 29, 2026

Fund ownership

RYTM fund ownership
Holder% heldSharesValueReported
VANGUARD INDEX FUNDS-Vanguard Total Stock Market Index Fund3.14%2,176,750248.02MJun 29, 2026
PRIMECAP Odyssey Funds-PRIMECAP Odyssey Aggressive Growth Fund2.79%1,935,739220.56MSep 29, 2026
SmallCap World Fund Inc2.55%1,769,519201.62MSep 29, 2026
VANGUARD INDEX FUNDS-Vanguard Small-Cap Index Fund2.27%1,572,293179.15MJun 29, 2026
iShares Trust-iShares Russell 2000 ETF2.16%1,496,330170.49MSep 29, 2026
SPDR SERIES TRUST-State Street SPDR S&P Biotech ETF1.71%1,184,359134.95MSep 29, 2026