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Denali Therapeutics Inc. DNLI

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20.29 USD -0.68 (-3.22%)

Nov 5, 2026, 11:27 AM EST

20.05 Day range 20.97
13.75 52-week range 27.30
YTD
+22.86%
1 year
+36.23%

Financial health

Altman Z-Score

3.27 Safe zone

Bankruptcy-risk model: below 1.81 distress, above 2.99 safe.

Piotroski F-Score

2 / 9 Weak

Nine pass/fail tests of profitability, leverage and efficiency.

FMP rating

C-1 / 5 overall

  • DCF 2
  • Return on Equity 1
  • Return on Assets 1
  • Debt / Equity 2
  • P/E 1
  • P/B 2

Valuation

P/E -5.6×
FY 2016: -1.6×FY 2017: -2.7×FY 2018: -53.0×FY 2019: -8.4×FY 2020: 129×FY 2021: -18.7×FY 2022: -10.7×FY 2023: -20.2×FY 2024: -7.9×FY 2025: -5.6×
FY 2016 5y median -10.7× FY 2025
P/S 0.0×
FY 2016: 0.0×FY 2017: 0.0×FY 2018: 14.8×FY 2019: 62.4×FY 2020: 27.2×FY 2021: 111×FY 2022: 32.2×FY 2023: 8.9×FY 2024: 0.0×FY 2025: 0.0×
FY 2016 5y median 8.9× FY 2025
P/B 2.9×
FY 2016: 0.5×FY 2017: 0.5×FY 2018: 3.5×FY 2019: 4.2×FY 2020: 7.9×FY 2021: 5.6×FY 2022: 3.3×FY 2023: 2.9×FY 2024: 2.7×FY 2025: 2.9×
FY 2016 5y median 2.9× FY 2025
P/FCF -6.9×
FY 2016: -1.8×FY 2017: -2.9×FY 2018: 41.0×FY 2019: -9.8×FY 2020: 22.1×FY 2021: -24.6×FY 2022: -13.3×FY 2023: -7.9×FY 2024: -9.2×FY 2025: -6.9×
FY 2016 5y median -9.2× FY 2025
EV/EBITDA -5.5×
FY 2016: -1.1×FY 2017: -0.2×FY 2018: -47.1×FY 2019: -8.1×FY 2020: 122×FY 2021: -18.4×FY 2022: -10.6×FY 2023: -22.4×FY 2024: -6.5×FY 2025: -5.5×
FY 2016 5y median -10.6× FY 2025
EV/Sales 0.0×
FY 2016: 0.0×FY 2017: 0.0×FY 2018: 14.2×FY 2019: 62.2×FY 2020: 25.9×FY 2021: 107×FY 2022: 30.7×FY 2023: 8.7×FY 2024: 0.0×FY 2025: 0.0×
FY 2016 5y median 8.7× FY 2025
FCF Yield -14.6%
FY 2016: -57.0%FY 2017: -34.0%FY 2018: 2.4%FY 2019: -10.2%FY 2020: 4.5%FY 2021: -4.1%FY 2022: -7.5%FY 2023: -12.6%FY 2024: -10.8%FY 2025: -14.6%
FY 2016 5y median -10.8% FY 2025

Profitability

Gross Margin 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 100.0%FY 2019: 100.0%FY 2020: 100.0%FY 2021: 100.0%FY 2022: 100.0%FY 2023: 100.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 100.0% FY 2025
Operating Margin 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: -35.9%FY 2019: -799.1%FY 2020: 18.7%FY 2021: -607.8%FY 2022: -314.2%FY 2023: -59.5%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median -59.5% FY 2025
Net Margin 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: -28.1%FY 2019: -740.7%FY 2020: 21.2%FY 2021: -597.2%FY 2022: -300.6%FY 2023: -43.9%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median -43.9% FY 2025
ROE -50.6%
FY 2016: -34.0%FY 2017: -18.9%FY 2018: -6.6%FY 2019: -50.0%FY 2020: 6.2%FY 2021: -30.2%FY 2022: -31.3%FY 2023: -14.1%FY 2024: -34.4%FY 2025: -50.6%
FY 2016 5y median -31.3% FY 2025
ROIC -52.6%
FY 2016: -33.4%FY 2017: -19.1%FY 2018: -7.4%FY 2019: -41.6%FY 2020: 4.0%FY 2021: -28.6%FY 2022: -30.9%FY 2023: -18.2%FY 2024: -38.0%FY 2025: -52.6%
FY 2016 5y median -30.9% FY 2025
ROA -44.8%
FY 2016: -32.0%FY 2017: -18.1%FY 2018: -5.5%FY 2019: -35.7%FY 2020: 4.4%FY 2021: -20.7%FY 2022: -22.3%FY 2023: -12.6%FY 2024: -30.8%FY 2025: -44.8%
FY 2016 5y median -22.3% FY 2025

Growth (YoY)

Revenue 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: -79.3%FY 2020: 1158.2%FY 2021: -85.5%FY 2022: 122.9%FY 2023: 204.7%FY 2024: -100.0%FY 2025: 0.0%
FY 2016 FY 2025
Operating Income -14.0%
FY 2016: -424.2%FY 2017: -3.1%FY 2018: 48.6%FY 2019: -359.7%FY 2020: 129.4%FY 2021: -571.6%FY 2022: -15.2%FY 2023: 42.3%FY 2024: -147.8%FY 2025: -14.0%
FY 2016 FY 2025
EPS (diluted) -15.6%
FY 2016: -141.8%FY 2017: 56.3%FY 2018: 93.4%FY 2019: -430.8%FY 2020: 130.4%FY 2021: -479.4%FY 2022: -8.8%FY 2023: 59.2%FY 2024: -142.5%FY 2025: -15.6%
FY 2016 FY 2025
Free Cash Flow -16.1%
FY 2016: -333.3%FY 2017: -1.3%FY 2018: 158.8%FY 2019: -462.8%FY 2020: 343.7%FY 2021: -153.2%FY 2022: -19.4%FY 2023: -41.3%FY 2024: 2.0%FY 2025: -16.1%
FY 2016 FY 2025

Financial Health

Current Ratio 9.2×
FY 2016: 20.0×FY 2017: 28.9×FY 2018: 14.7×FY 2019: 9.5×FY 2020: 20.9×FY 2021: 2.4×FY 2022: 3.8×FY 2023: 13.6×FY 2024: 8.5×FY 2025: 9.2×
FY 2016 5y median 8.5× FY 2025
Quick Ratio 9.2×
FY 2016: 20.0×FY 2017: 29.0×FY 2018: 14.9×FY 2019: 9.5×FY 2020: 20.9×FY 2021: 2.4×FY 2022: 3.8×FY 2023: 13.6×FY 2024: 8.5×FY 2025: 9.2×
FY 2016 5y median 8.5× FY 2025
Debt / Equity 0.0×
FY 2016: 0.0×FY 2017: 0.0×FY 2018: 0.0×FY 2019: 0.2×FY 2020: 0.1×FY 2021: 0.1×FY 2022: 0.1×FY 2023: 0.1×FY 2024: 0.0×FY 2025: 0.0×
FY 2016 5y median 0.1× FY 2025
Net Debt / EBITDA 0.3×
FY 2016: 0.5×FY 2017: 2.5×FY 2018: 2.0×FY 2019: 0.0×FY 2020: -6.2×FY 2021: 0.8×FY 2022: 0.5×FY 2023: 0.6×FY 2024: 0.3×FY 2025: 0.3×
FY 2016 5y median 0.5× FY 2025
Interest Coverage 0.0×
FY 2016: 0.0×FY 2017: -46.1×FY 2018: 0.0×FY 2019: 0.0×FY 2020: 0.0×FY 2021: 0.0×FY 2022: 0.0×FY 2023: 0.0×FY 2024: 0.0×FY 2025: 0.0×
FY 2016 5y median 0.0× FY 2025

Dividends

Dividend Yield 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025
Payout Ratio 0.0%
FY 2016: 0.0%FY 2017: 0.0%FY 2018: 0.0%FY 2019: 0.0%FY 2020: 0.0%FY 2021: 0.0%FY 2022: 0.0%FY 2023: 0.0%FY 2024: 0.0%FY 2025: 0.0%
FY 2016 5y median 0.0% FY 2025

Annual · latest fiscal year ends 2025-12-31