Benzinga's Top Pre-Market NASDAQ Losers (ARNA, OREX, ACFN, VVUS)

Arena Pharmaceuticals Inc (NASDAQ: ARNA) dipped 44.12% to $2.09 in the pre-market session. Analysts at Piper Jaffray downgrade ARNA from "overweight" to "neutral." Orexigen Therapeutics Inc (NASDAQ: OREX) lost 9.01% to $6.16 in the pre-market session. OREX shares have fallen 26.65% over the past 52-weeks, while the S&P500 index has gained 5.55% in the same period. Acorn Energy Inc (NASDAQ: ACFN) fell 6.58% to $4.40 in the pre-market session. ACFN shares have fallen 15.44% over the past 52-weeks, while the S&P500 index has gained 5.55% in the same period. VIVUS Inc (NASDAQ: VVUS) slipped 5.59% to $5.91 in the pre-market trading. VVUS' shares have fallen 40.78%over the past 52-weeks, while the S&P500 index has gained 5.55% in the same period. Read more from Benzinga's Markets.