CRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious human diseases using its Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. Its CRISPR/Cas9 is a gene editing technology that allows for precise directed changes to genomic DNA. The company has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, immune-oncology and autoimmune, in vivo, and type 1 diabetes. The company's lead product candidate is CASGEVY, an ex vivo CRISPR/Cas9 gene-edited cell therapy for treating patients suffering from transfusion-dependent beta-thalassemia, severe sickle cell disease, and hemoglobinopathies in which a patient's hematopoietic stem and progenitor cells are edited to produce high levels of fetal hemoglobin in red blood cells. It also develops CAR T cell therapies, including CTX112 targeting CD19 and CTX131 targeting CD70 for oncology and autoimmunune indications; CTX310 and CTX320, in vivo gene editing to address the cardiovascular disease by disrupting the validated targets angiopoietin-like protein 3 and lipoprotein; and VCTX211, an allogeneic, gene-edited, hypoimmune stem cell-derived product candidate for the treatment of T1D. It has strategic partnerships with Vertex Pharmaceuticals Incorporated, ViaCyte, Inc., Nkarta, Inc., and Capsida Biotherapeutics. CRISPR Therapeutics AG was incorporated in 2013 and is headquartered in Zug, Switzerland.
Date |
For |
Estimate |
Reported |
Surprise |
surprise % |
2024-05-13 |
2024-03 |
-1.63 |
N/A |
N/A |
N/A |
2024-02-21 |
2023-12 |
-0.4 |
1.1 |
1.5 |
375.00% |
2023-11-06 |
2023-09 |
-1.98 |
-1.41 |
0.57 |
28.79% |
2023-08-07 |
2023-06 |
-2.18 |
-0.98 |
1.2 |
55.05% |
2023-05-08 |
2023-03 |
-1.67 |
-0.67 |
1 |
59.88% |
2023-02-21 |
2022-12 |
-2.32 |
-1.41 |
0.91 |
39.22% |
Date |
Firm |
Action |
From |
To |
2023-10-16 |
Cantor Fitzgerald |
Downgrade |
Overweight |
Neutral |
2023-09-26 |
Mizuho |
Upgrade |
|
Buy |
2023-08-17 |
Citigroup |
Upgrade |
Neutral |
Buy |
2023-08-16 |
Citigroup |
Upgrade |
Neutral |
Buy |
2023-08-13 |
Morgan Stanley |
Upgrade |
Underweight |
Underweight |
2023-08-09 |
Oppenheimer |
Upgrade |
Outperform |
Outperform |
Date |
Name |
Relation |
Quantity |
Description |
2021-07-18 |
BOLZON BRADLEY J |
Director |
0.00 |
Sale |
2024-02-26 |
GEORGE SIMEON J. |
Director |
0.00 |
Stock Award(Grant) |
2021-12-02 |
HO TONY W |
Officer |
52.36K |
Conversion of Exercise of derivative security |
2024-03-11 |
KASINGER JAMES R. |
General Counsel |
61.17K |
Sale |
2022-03-10 |
KLEIN LAWRENCE OTTO |
Chief Operating Officer |
26.80K |
Conversion of Exercise of derivative security |
2024-04-14 |
KULKARNI SAMARTH |
Chief Executive Officer |
408.12K |
Sale |
Institution Ownership
...
Report Date |
Organization |
Position |
Value |
Percentage |
2023-09-29 |
ARK Investment Management, LLC |
7.16M |
325.13M |
9.02% |
2023-06-29 |
Capital International Investors |
6.07M |
340.75M |
7.64% |
2023-06-29 |
T. Rowe Price Investment Management, Inc. |
3.65M |
204.72M |
4.59% |
2023-06-29 |
Nikko Asset Management Americas, Inc. |
3.53M |
198.36M |
4.45% |
2023-06-29 |
Sumitomo Mitsui Trust Holdings, Inc. |
3.53M |
198.36M |
4.45% |
2023-06-29 |
Blackrock Inc. |
2.72M |
152.62M |
3.42% |
Report Date |
Organization |
Position |
Value |
Percentage |
2023-09-29 |
ARK ETF Tr-ARK Innovation ETF |
4.91M |
223.04M |
6.19% |
2023-06-29 |
New Perspective Fund Inc |
3.55M |
199.33M |
4.47% |
2023-09-29 |
ARK ETF Tr-ARK Genomic Revolution ETF |
1.51M |
68.71M |
1.91% |
2023-06-29 |
Price (T.Rowe) Mid Cap Growth Fund |
1.20M |
67.33M |
1.51% |
2023-08-30 |
SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF |
1.14M |
57.16M |
1.44% |
2023-06-29 |
Vanguard Extended Market Index Fund |
1.09M |
61.34M |
1.38% |